Impact of Intangible Factors on Business Value

The global financial and economic crisis of 2008-2009 has caused a significant drop in business efficiency. Today’s management model of the overwhelming majority of companies is oriented towards satisfying the interests of owners and business groups, while the interests of clients, creditors, state and society are not sufficiently taken into account. This creates barriers to the growth of business value, which today has become a generally recognized indicator of the success, sustainability and investment attractiveness of companies. It is the reason for the introduction of the policy of value-oriented management of a company aimed at preserving and increasing the value of business, harmonizing the economic interests of all its stakeholder

INFLUENCE CHRONICKIDNEYDISEASEPROGRESSES TO QUALITYOFLIFE

Aim. To determine the characteristics of quality of life in patients with chronic kidney disease (CKD ) II–Vst. Methods. 171 patients with CKD II–IVst, except for routine clinical and laboratory examinations, have been studied the quality of life (QOL) using a questionnaire assessing quality of life SF– 36. Results. It was found most of the QOL was significantly worse with the progression of CKD. Total QOL indicators and indicator “effect of kidney disease”. most significantly reduced. Correlation most QOL with age, hemoglobin, blood pressure levels was revealed. Conclusions. QOL decrease with the progression of CKD. Age, hemoglobin level, blood pressure affect QOL

Адміністративна відповідальність за службові правопорушення у сфері земельних відносин в Україні

Красюк, Н. І. Адміністративна відповідальність за службові правопорушення у сфері земельних відносин в Україні / Н. І. Красюк // Європейські перспективи. – 2014. – № 9. – С. 128-135.У статті досліджуються питання, присвячені особливостям адміністративної відповідальності за службові правопорушення в сфері земельних відносин. Автором запропонований термін «службове адміністративне правопорушення в сфері земельних відносин», систематизовано склади таких проступків, а також визначені напрями вдосконалення чинного законодавства України в цій сфері.The article examines the issues about a specific administrative responsibility for service offenses in the sphere of land relations. The author suggests the term “service administrative offenses in the sphere of land relations”, a systematic components of such offences, and identifies ways of improving the current legislation of Ukraine in this sphere.В статье исследуются вопросы, посвященные особенностям административной ответственности за служебные правонарушения в сфере земельных отношений. Автором предложен термин «служебное административное правонарушение в сфере земельных отношений», систематизированы составы таких проступков, а также определены направления совершенствования действующего законодательства Украины в этой сфере

Pneumonia in patients with chronic kidney disease V D stage: pathogenetic aspects of complex therapy and outcomes

Abstract.The aim of our study was to increase the effectiveness of treatment of comorbid pneumonia in patients with CKD VD stage. Materials and Methods. 73 patients with CKD VD st. (59 on HD and 14 on PD) with mild to moderate comorbid pneumonia who received renal replacement therapy (RRT) during 2013-2016 were included in the observational prospective open-label randomized trial. Patients were randomized into two groups: group 1 (n = 42) included patients who in addition to the conventional therapy of pneumonia received medication «Lipin» as a complex therapy; group 2 included patients (n = 31) who received only basic (traditional) therapy. The groups were representative by the main demographic, social and clinical-laboratory findings, severity of pneumonia, duration and modality of RRT. The primary endpoints were death from any cause and episodes of rehospitalization. The overall assessment of the clinical efficacy of the therapy was based on a comparison of the duration of hospitalization, antibiotic therapy, intoxication syndrome, and regression of X-ray changes. Survival in observation groups was determined by the Kaplan-Meier method. Analyzed cases were included to October 31, 2018. The markers of oxidative stress (OS) were determined in 29 patients of group 1 and 14 patients of group 2 before treatment and after 14 days while treatment of  pneumonia was started. Results. The analysis demonstrated that during a 1-year period a 17 (25,76%) episodes of rehospitalization were recorded: 11 causes (35.5%) in group 1 and 6 (14.3%) in group 2 (χ² = 4.486, p = 0.035). In total, 29 deaths were recorded during the study period: 10 (23.8%) cases in group 1, and 19 (61.3%) - in group 2 (χ² = 8.957, p = 0.003, RR - 2.574, 95% CI: 1.400-4.733). The three- and five-year cumulative survival rates were 83% vs. 21% and 59% vs. 21%, in the group 1 and group 2, respectively (p = 0.00003). It was stated that the duration of hospitalization, antibiotic therapy, intoxication syndrome and X-ray regression were significantly lower in group 1 compared with group 2 (p <0.05). The comparative analysis of dynamics in the groups shows that increasing the treatment effectiveness at complex therapy background accompanied by a significant positive dynamics of OS markers (p <0,05). Conclusions Thus, the results of this study demonstrated the effectiveness of complex method of pneumonia treatment in patients with CKD stage 5D including Lipin medication compared traditional therapy. There is a significant difference in patient survival depending on the proposed and generally accepted treatment

NUTRITIONAL DISTURBANCES IN PATIENTS WITH CHRONIC KIDNEY DISEAS STAGE WHO ARE TREATED BY PERITONEAL DIALYSIS AND ITS RELATIONSHIPS WITH HYDRATION STATUS

The aim of the study was to estimate the nutritional status of patients with chronic kidney disease who are treated by CAPD, the prevalence of its disorders according to functional methods. To study the relationship between nutritional status and hydration. Materials and Methods: During the observational one-stage study, 105 patients with CKD 5D stage who were treated by CAPD were included. To assess the NS, serum albumin and body mass index were determined, functional methods were used, namely, SGA and dietary diary analysis. The status of hydration was assessed by clinical examination and bioimpedance analysis. The study was carried out in two stages. At the first, the definition of laboratory and functional indicators of the National Assembly, assessment of the balance of water sectors was carried out. At the second stage, for further analysis, the patients were divided into four groups according to the condition of the NS, determined on the basis of the SGA: the first group (n = 54) consisted of patients without disturbance of nutrition, the second (n = 27) with mild disruption of nutrition, the third (n = 13) — with an average degree, and the fourth (n = 11) - with a severe degree of malnutrition. Results: Weight loss and subcutaneous fat mass for the past 6 months were detected in 43.8% and 37.14% of patients, respectively. Gastrointestinal disorders and loss of muscle mass were detected in 58.1% and 74.3% of patients, respectively. According to the SGA, nutritional disorders were detected in 51 (48.6%) patients. An easy degree of malnutrition was diagnosed in 25.71% of patients, medium and severe — in 12.38% and 10.48% of patients, respectively. For compare of the data obtained from the survey on the composition of water sectors with reference values allows one to assert the presence of hyperhydration in the examined population. A statistically significant difference is achieved by the volume of extracellular fluid, the volume of circulating blood and plasma. These parameters significantly increase depending on the degree of disturbance of the NS (p <0.001). A direct, reliable correlation was obtained between the SGA and serum albumin level (r = 0.74, p <0.0001), BMI (r = 0.55, p <0.0001) and the inverse volume of extracellular fluid (r = -0, 71; p <0.0001). Peripheral edema as a sign of hyperhydration was detected in 31 patients, the significant majority of whom belonged to the third (10 / 37.03% versus 11 / 84.6%, x2 = 7.965, р = 0.005) and the fourth (10/ 37.03 % against 10 /90,9%, yf = 9,098, р = 0,003) to the group. Daily protein intake, also, was significantly lower in patients of the third and fourth groups (p <0.001). Conclusions: Thus, the normal nutritional status was determined in more than 50% of the patients examined. The level of hydration in patients with nutritional disorders is higher than in patients with normal nutritional status. The received data testify to the necessity of constant monitoring of laboratory and functional indices of NS, expediency of routine use of bioimpedance analysis for hydration estimation

AUTONOMIC STATUS OF PERITONEAL DIALYSIS PATIENTS AND ITS RELATION WITH INDICATORS OF LIPID METABOLISM

The research objective had been to evaluate the autonomic status in peritoneal dialysis (PD) patients and to identify its lipid metabolism interaction. Patients and methods. During the research process 40patients had been examined who received continuous ambulatory peritoneal dialysis (CAPD). The autonomic status was studied using the questionnaire (A.N. Wayne test) and sympathetic skin response (SSR) by electroneuromyograph «Neuro–MEP–4». 20 conventionally healthy individuals formed the control group matched according to age and sex. Results. Obtained questionnaire data showed clinical symptoms of autonomic dysfunction in 37 cases among 40 (92,5%) PD patients. Analysis of the correlation level of autonomic disorders with lipid metabolism showed a significant dependence with the concentration of high density lipoprotein (HDL) (p=–0,43;p=0,01), low density lipoprotein (LDL) (p=0,55; p=0,001) and atherogenic index. Also a comparative analysis of the main CSAP PD patients’ indicators and conditionally healthy individuals showed a statistically significant decrease in the amplitudes of the first and second phases of SSR. Also SSR results analysis in conjunction with the autonomic disorders clinical implications afforded the ground for the lower extremities polyneuropathy diagnosis in 18 cases among 25 (72%) patients. Moreover, the study of lipid profile showed the correlation of total cholesterol (TC) with all studied SSR parameters: A1 (r=0,64; p=0,0006), A2 (r=0,79; p<0,0001), latent period (LP) (r=–0,45; p=0,04). Conclusions. The autonomic status of CAPD patients is characterized by low level of vegetative regulation total power and the imbalance of sympathetic and parasympathetic influences in comparison with conventionally healthy individuals and it is correlated with lipid spectrum

Legal protection of inventions within medical practice in Ukraine

Legal protection of inventions within medical practice in Ukraine / Bezpalova О.I., Yusupov V.A., Avramova O.Ye., Krasiuk T.V., Larina N.B. // Wiadomości Lekarskie. 2019. Tom LXXII. № 3. p. 484-488. http://wl.medlist.org/2019_03_30/The aim of this article is theoretical and practical study of the legal protection of medical inventions in Ukraine based on the analysis of Ukrainian patent law, issued patents for inventions applied within medical practice, as well as data from the State Expert Center of the Ministry of Health of Ukrain