661 research outputs found
Quantitative predictions on auxin-induced polar distribution of PIN proteins during vein formation in leaves
The dynamic patterning of the plant hormone auxin and its efflux facilitator
the PIN protein are the key regulator for the spatial and temporal organization
of plant development. In particular auxin induces the polar localization of its
own efflux facilitator. Due to this positive feedback auxin flow is directed
and patterns of auxin and PIN arise. During the earliest stage of vein
initiation in leaves auxin accumulates in a single cell in a rim of epidermal
cells from which it flows into the ground meristem tissue of the leaf blade.
There the localized auxin supply yields the successive polarization of PIN
distribution along a strand of cells. We model the auxin and PIN dynamics
within cells with a minimal canalization model. Solving the model analytically
we uncover an excitable polarization front that triggers a polar distribution
of PIN proteins in cells. As polarization fronts may extend to opposing
directions from their initiation site we suggest a possible resolution to the
puzzling occurrence of bipolar cells, such we offer an explanation for the
development of closed, looped veins. Employing non-linear analysis we identify
the role of the contributing microscopic processes during polarization.
Furthermore, we deduce quantitative predictions on polarization fronts
establishing a route to determine the up to now largely unknown kinetic rates
of auxin and PIN dynamics.Comment: 9 pages, 4 figures, supplemental information included, accepted for
publication in Eur. Phys. J.
Development of very-high-density low-enriched-uranium fuels
The RERTR program has recently begun an aggressive effort to develop dispersion fuels for research and test reactors with uranium densities of 8 to 9 g U/cm{sup 3}, based on the use of {gamma}-stabilized uranium alloys. Fabrication development teams and facilities are being put into place and preparations for the first irradiation test are in progress. The first screening irradiations are expected to begin in late April 1997 and first results should be available by end of 1997. Discussions with potential international partners in fabrication development and irradiation testing have begun
A Micro-Costing Framework for Circulating Tumor DNA Testing in Dutch Clinical Practice
Circulating tumor DNA (ctDNA) is a promising new biomarker with multiple potential applications in cancer care. Estimating total cost of ctDNA testing is necessary for reimbursement and implementation, but challenging because of variations in workflow. We aimed to develop a micro-costing framework for consistent cost calculation of ctDNA testing. First, the foundation of the framework was built, based on the complete step-wise diagnostic workflow of ctDNA testing. Second, the costing method was set up, including costs for personnel, materials, equipment, overhead, and failures. Third, the framework was evaluated by experts and applied to six case studies, including PCR-, mass spectrometry–, and next-generation sequencing–based platforms, from three Dutch hospitals. The developed ctDNA micro-costing framework includes the diagnostic workflow from blood sample collection to diagnostic test result. The framework was developed from a Dutch perspective and takes testing volume into account. An open access tool is provided to allow for laboratory-specific calculations to explore the total costs of ctDNA testing specific workflow parameters matching the setting of interest. It also allows to straightforwardly assess the impact of alternative prices or assumptions on the cost per sample by simply varying the input parameters. The case studies showed a wide range of costs, from €168 to €7638 (9124) per sample, and generated information. These costs are sensitive to the (coverage of) platform, setting, and testing volume
Observing the First Stars and Black Holes
The high sensitivity of JWST will open a new window on the end of the
cosmological dark ages. Small stellar clusters, with a stellar mass of several
10^6 M_sun, and low-mass black holes (BHs), with a mass of several 10^5 M_sun
should be directly detectable out to redshift z=10, and individual supernovae
(SNe) and gamma ray burst (GRB) afterglows are bright enough to be visible
beyond this redshift. Dense primordial gas, in the process of collapsing from
large scales to form protogalaxies, may also be possible to image through
diffuse recombination line emission, possibly even before stars or BHs are
formed. In this article, I discuss the key physical processes that are expected
to have determined the sizes of the first star-clusters and black holes, and
the prospect of studying these objects by direct detections with JWST and with
other instruments. The direct light emitted by the very first stellar clusters
and intermediate-mass black holes at z>10 will likely fall below JWST's
detection threshold. However, JWST could reveal a decline at the faint-end of
the high-redshift luminosity function, and thereby shed light on radiative and
other feedback effects that operate at these early epochs. JWST will also have
the sensitivity to detect individual SNe from beyond z=10. In a dedicated
survey lasting for several weeks, thousands of SNe could be detected at z>6,
with a redshift distribution extending to the formation of the very first stars
at z>15. Using these SNe as tracers may be the only method to map out the
earliest stages of the cosmic star-formation history. Finally, we point out
that studying the earliest objects at high redshift will also offer a new
window on the primordial power spectrum, on 100 times smaller scales than
probed by current large-scale structure data.Comment: Invited contribution to "Astrophysics in the Next Decade: JWST and
Concurrent Facilities", Astrophysics & Space Science Library, Eds. H.
Thronson, A. Tielens, M. Stiavelli, Springer: Dordrecht (2008
Demonstration of the temporal matter-wave Talbot effect for trapped matter waves
We demonstrate the temporal Talbot effect for trapped matter waves using
ultracold atoms in an optical lattice. We investigate the phase evolution of an
array of essentially non-interacting matter waves and observe matter-wave
collapse and revival in the form of a Talbot interference pattern. By using
long expansion times, we image momentum space with sub-recoil resolution,
allowing us to observe fractional Talbot fringes up to 10th order.Comment: 17 pages, 7 figure
Azimuthal anisotropy and correlations in p+p, d+Au and Au+Au collisions at 200 GeV
We present the first measurement of directed flow () at RHIC. is
found to be consistent with zero at pseudorapidities from -1.2 to 1.2,
then rises to the level of a couple of percent over the range . The latter observation is similar to data from NA49 if the SPS rapidities
are shifted by the difference in beam rapidity between RHIC and SPS.
Back-to-back jets emitted out-of-plane are found to be suppressed more if
compared to those emitted in-plane, which is consistent with {\it jet
quenching}. Using the scalar product method, we systematically compared
azimuthal correlations from p+p, d+Au and Au+Au collisions. Flow and non-flow
from these three different collision systems are discussed.Comment: Quark Matter 2004 proceeding, 4 pages, 3 figure
Azimuthal anisotropy: the higher harmonics
We report the first observations of the fourth harmonic (v_4) in the
azimuthal distribution of particles at RHIC. The measurement was done taking
advantage of the large elliptic flow generated at RHIC. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 4 pages, 6 figures, contribution to the Quark Matter 2004 proceeding
Kaon Production and Kaon to Pion Ratio in Au+Au Collisions at \snn=130 GeV
Mid-rapidity transverse mass spectra and multiplicity densities of charged
and neutral kaons are reported for Au+Au collisions at \snn=130 GeV at RHIC.
The spectra are exponential in transverse mass, with an inverse slope of about
280 MeV in central collisions. The multiplicity densities for these particles
scale with the negative hadron pseudo-rapidity density. The charged kaon to
pion ratios are and
for the most central collisions. The ratio is lower than the same
ratio observed at the SPS while the is higher than the SPS result.
Both ratios are enhanced by about 50% relative to p+p and +p
collision data at similar energies.Comment: 6 pages, 3 figures, 1 tabl
All-optical switching and strong coupling using tunable whispering-gallery-mode microresonators
We review our recent work on tunable, ultrahigh quality factor
whispering-gallery-mode bottle microresonators and highlight their applications
in nonlinear optics and in quantum optics experiments. Our resonators combine
ultra-high quality factors of up to Q = 3.6 \times 10^8, a small mode volume,
and near-lossless fiber coupling, with a simple and customizable mode structure
enabling full tunability. We study, theoretically and experimentally, nonlinear
all-optical switching via the Kerr effect when the resonator is operated in an
add-drop configuration. This allows us to optically route a single-wavelength
cw optical signal between two fiber ports with high efficiency. Finally, we
report on progress towards strong coupling of single rubidium atoms to an
ultra-high Q mode of an actively stabilized bottle microresonator.Comment: 20 pages, 24 figures. Accepted for publication in Applied Physics B.
Changes according to referee suggestions: minor corrections to some figures
and captions, clarification of some points in the text, added references,
added new paragraph with results on atom-resonator interactio
Strange Resonance Production in p+p and Au+Au Collisions at RHIC Energies
Resonance yields and spectra from elementary p+p and Au+Au collisions at
200 GeV from the STAR experiment at RHIC are presented
and discussed in terms of chemical and thermal freeze-out conditions. Thermal
models do not adequately describe the yields of the resonance production in
central Au+Au collisions. The approach to include elastic hadronic interactions
between chemical freeze-out and thermal freeze-out suggests a time of 5 fm/c.Comment: 4 pages, 7 figures, proceedings of the Quark Matter 2004, in Oakland,
California, to be published in Journal of Physics G: Nuclear and Particle
Physic
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