Candida auris: a literature review

Background: Emerging pathogen Candida auris has been associated with nosocomial outbreaks demonstrating widespread antifungal resistance. This microorganism is associated with systemic infections with a high mortality rate, and studies that contribute to a better understanding of this agent are important. Objectives: The present article aimed to carry out bibliographic research on Candida auris. Therefore, a literature search was carried out between January 2018 and January 2022, applying the following: C. auris; Candida auris and Infection, in Portuguese, English and Spanish. This review considers the available literature on C. auris and highlights key unknowns, which will provide guidance for future work in this field. Results: The data collected in the present review allowed us to divide the theme into topics on Pathophysiology, Epidemiology/clinical and drug resistance mechanisms, so that the understanding of Candida auris can be better detailed and understood. Conclusion: The predilection of C. auris by the most vulnerable and immunosuppressed patients or with comorbidities and with the potential to cause invasive and bloodstream infections with a propensity to cause outbreaks and concerns regarding resistance to antifungal agents, the fungus Candida auris, is of increasing clinical relevance. The increase in the number of detected cases and the occurrence of strains with multiple drug resistance prove to be worrisome, and applied research is essential to contribute to the knowledge of this strain and effective therapy

Antibacterial Effect of Silver Nanoparticles on Klebsiella spp

Silver nanoparticles (AgNP) can be incorporated into medical devices, such as tissues, to circumvent bacterial resistance such as Klebsiella spp, which can lead to skin and mucosal infections. Thus, the aim of the present study was to synthesize silver nanoparticles for later incorporation into cotton fabrics and in vitro tests against Klebsiella spp. The AgNP colloidal solution was synthesized (AgNO3 - 0.1 mM, 100 mM trisodium citrate, polyvinylpyrrolidone - 0.24 g, H2OH2) and then impregnated into the cotton fabric pretreated with poly diallyl dimethylammonium chloride (PDDA) of 100/500 tissue, shaken for 30 minutes). The material produced was analyzed by the FTIR; DLS and reflectance spectroscopy. The tests of the antimicrobial activities were by the microdilution technique against Klebsiella spp, in tubes containing Brain Heart Infusion (BHI), with the solution of silver (1); Tissue containing AgNP - 4 mm (2); Negative control (3) and positive control - ceftriaxone (4). Regarding MIC, the inhibitory activity occurred of the dilutions between 1/2 and 1/16. The AgNP particles had an average size of 24.75 nm. As synthesized AgNPs demonstrate the excellent antimicrobial activity against Klebsiella spp, with special emphasis on applications in nanotechnology and nanomedicine, targeting multiresistant antibiotic bacteria

Coronavirus Outbreaks: Literature Review

Coronaviruses are observed in birds and mammals and can be transmitted to humans, leading to outbreaks and pandemics. Among the most recent ones are SARS-CoV, MERS-CoV, and COVID 19. Thus, the objective was to describe a discussion about coronaviruses, with an emphasis on Sars-Cov-2. From the data collected, it can be seen that the current pandemic has had impacts on public health and socioeconomic life in more than 170 countries worldwide, to date, with tens of millions of people infected and hundreds of thousands of deaths. In this regard, prevention actions must be intensified, especially among the most vulnerable patients (the elderly and those with comorbidities that affect immunity). In addition, new studies should be carried out so that vaccines and antivirals can be implemented for application to COVID-19

Estudo comparativo da atuação do enfermeiro no controle de dengue e febre chikungunya

Resumo O objetivo deste estudo foi analisar a atuação dos enfermeiros das Estratégias de Saúde da Família no controle de dengue e febre chikungunya nos municípios de Parnamirim e Santa Cruz/RN. Trata-se de um estudo exploratório, descritivo, com abordagem qualitativa de tratamento e análise de dados. A coleta foi realizada entre novembro e dezembro de 2015 por meio de uma entrevista gravada, voltada às questões que abordam a ação da enfermagem e sua equipe no controle de dengue e febre chikungunya no campo de atuação da ESF. Utilizou-se como método de observação dos dados a análise de conteúdo de Bardin. Após análise, houve criação de duas categorias - educação em saúde e campanhas pontuais. Na primeira, os entrevistados informaram realizar palestras educativas, mas não explicam a metodologia usada e nem a participação popular, como também a articulação com o setor de endemias da cidade para fortalecer a discussão. Na segunda, algumas ações são assistencialistas de caráter campanhista/higienista, realizadas pelos enfermeiros dos municípios em campanhas de “higienização” e “limpeza”, as quais se mostram bastante presentes nas falas dos entrevistados. Há uma forte presença desse modelo enraizada tanto nas ações quanto na realização de atividades educativas, usando como metodologia a palestra. Além disso, há necessidade de se realizar mais estudos que aprofundem o tema abordado, a julgar por uma amostra pequena, especialmente no município de Parnamirim

Determination of the Biosorption of Cd(Ⅱ) by Coconut Fiber

Made available in DSpace on 2015-05-04T17:07:34Z (GMT). No. of bitstreams: 2 license.txt: 1914 bytes, checksum: 7d48279ffeed55da8dfe2f8e81f3b81f (MD5) mirian_pereiraetal_IOC_2014.pdf: 279050 bytes, checksum: 56b80540ed54c2c0f81bacc18831da2f (MD5) Previous issue date: 2014Universidade Federal do Rio Grande do Norte. Centro Tecnológico. Engenharia Mecânica. Natal. RN, Brasil / University of Coimbra. Centre of Chemical Processes Engineering and Forest Products (CIEPQPF), Coimbra, Portugal / Universidade Federal do Rio Grande do Norte. Faculdade de Ciências da Saúde do Traíri. Santa Cruz, RN, Brasil.Universidade Federal do Rio Grande do Norte. Centro Tecnológico. Engenharia Mecânica. Natal. RN, Brasil .Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas. Natal, RN, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Engenharia Têxtil. Natal, RN, Brasil.University of Coimbra. Centre of Chemical Processes Engineering and Forest Products (CIEPQPF). Coimbra, Portugal.University of Coimbra. Centre of Chemical Processes Engineering and Forest Products (CIEPQPF). Coimbra, Portugal.Universidade Federal do Rio Grande do Norte. Centro Tecnológico. Engenharia Mecânica. Natal. RN, Brasil / Fundação Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.The coconut fiber is produced in large quantities in Brazil, even though very small quantities are being used by some industries, mainly cordage mats and handicrafts. An alternative usage would be the use of these fibers in biosorption of heavy metals from aqueous solutions. This present study aimed to evaluate the potentiality of cadmium biosorption by coconut fiber. The coconut fibers were used at kinetic analysis, influence of pH and adsorption isotherms were also carried out. It can be concluded that there is great potential for the use of coconut fiber, and the optimum pH for adsorption was around 5.0. The adsorption kinetics is fast and equilibrium occurs within 120 min. The Langmuir isotherm was considered the most suitable to describe the experimental data