Gene Ontology curation of the blood-brain barrier to improve the analysis of Alzheimer's and other neurological diseases.

Funder: National Institute for Health Research University College London Hospitals Biomedical Research CentreThe role of the blood-brain barrier (BBB) in Alzheimer's and other neurodegenerative diseases is still the subject of many studies. However, those studies using high-throughput methods have been compromised by the lack of Gene Ontology (GO) annotations describing the role of proteins in the normal function of the BBB. The GO Consortium provides a gold-standard bioinformatics resource used for analysis and interpretation of large biomedical data sets. However, the GO is also used by other research communities and, therefore, must meet a variety of demands on the breadth and depth of information that is provided. To meet the needs of the Alzheimer's research community we have focused on the GO annotation of the BBB, with over 100 transport or junctional proteins prioritized for annotation. This project has led to a substantial increase in the number of human proteins associated with BBB-relevant GO terms as well as more comprehensive annotation of these proteins in many other processes. Furthermore, data describing the microRNAs that regulate the expression of these priority proteins have also been curated. Thus, this project has increased both the breadth and depth of annotation for these prioritized BBB proteins. Database URLhttps://www.ebi.ac.uk/QuickGO/

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world's largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases.

RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world's largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org

Student’s attitudes towards of adulthood in the perspective of family determinants.

Celem niniejszej pracy było poznanie i analiza postaw studentów wobec dorosłości z punktu widzenia uwarunkowań rodzinnych. Przedmiotem badań były postawy studiujących wobec pełnienia przez nich ról małżeńskich i rodzicielskich, podejmowania pracy, postawy wobec samodzielności ekonomicznej, oraz stosunek badanego do sformułowania aspiracji życiowych.Praca składa się z trzech części. Pierwsza zawiera teoretyczny opis stosowanych pojęć, takich jak postawa, dorosłość, zadania rozwojowe, a także zamieszono tu opis rodziny ze szczególnym uwzględnieniem jej charakterystyki jako środowiska socjalizacyjno - wychowawczego. W drugiej części omówiono założenia metodologiczne badań własnych. Natomiast trzecia część obejmuje analizę uzyskanych wyników. W wyniku przeprowadzonych badań można stwierdzić, że cechy strukturalne rodziny i sposób jej funkcjonowania (np. typ rodziny, status materialny, wykształcenie rodziców, relacje badanego z rodzeństwem) jak również postawy rodzicielskie rodziców wpływają na postawy studentów wobec większości zadań typowych dla tego okresu.The purpose of this paper was to investigate and analyze the attitudes of students towards of adulthood in the perspective of family determinants. The subjects of the study were attitudes of students to performing their matrimonial and parental roles, attitude towards work, attitudes toward economic independence and the ratio to formulate life aspirations.The work consists of three parts. The first part contains a theoretical description of the words such as attitude, adulthood, developmental tasks. Also, in this part the family has been described with particular reference to its characteristics as an educational and socialization groups.The second part discusses the methodological assumptions of this research. The third part includes an analysis of the results. As a result of the studies it can be concluded that the structural characteristics of the family and the way it is functioning (e.g. family type, economic status, parent’s education, relationships with siblings) as well as parental attitudes of parents influence the attitudes of students towards the majority of tasks typical for this period

Protection of children's rights in Poland

Celem niniejszej pracy było zbadanie i przeanalizowanie przepisów prawnych dotyczących ochrony praw dziecka w Polsce. Przedmiotem badań były, przede wszystkim, najważniejsze akty obowiązujące na terenie Rzeczypospolitej, takie jak Konstytucja RP z 1997 roku, Konwencja o Prawach Dziecka, oraz najważniejsze ustawy regulujące prawa młodych ludzi. Praca składa się z czterech rozdziałów. Pierwszy rozdział dotyczy ewolucji praw dziecka na świecie i wpływu tej ewolucji na ustawodawstwo krajowe. W drugim rozdziale zostaje zaprezentowana prawna definicja dziecka, zgodna z ustawodawstwem wewnętrznym. Trzeci rozdział obejmuje katalog praw dziecka, ze szczególnym uwzględnieniem specyfiki rozwojowej młodego człowieka, co znajduje swoje przełożenie w konkretnych regulacjach. Czwarty rozdział prezentuje organy i instytucje stojące na straży praw dziecka. W wyniku przeprowadzonej analizy należy stwierdzić, że mnogość przepisów dotyczących praw dziecka oraz instytucji kontrolnych, zapewnia ochronę tychże praw na terytorium Rzeczypospolitej Polskiej. Ale skuteczna ochrona możliwa jest jedynie na skutek pełnego współdziałania sektorów rządowego i pozarządowego.The purpose of this study was to investigate and analyze the legislation on the protection of children's rights in Poland. The subject of the study were, first of all, the most important acts in force in the Republic of Poland, such as the Poland's 1997 Constitution, the Convention on the Rights of the Child, and the most important laws regulating the rights of young people.The work is consists of four chapters. The first chapter concerns the evolution of children's rights in the world and the impact of these evolution on the national legislation. The second chapter is presented legal definition of the child, in accordance with internal law. The third section includes a catalog of the rights of children, with particular emphasis on specific maturation of a young man, and this is reflected in the concrete regulations. The fourth section presents the authorities and institutions of guarding the rights of the child. The analysis should be noted, that the multiplicity of rules concerning children's rights and control institutions provides protection of these rights in the territory of the Polish Republic. But effective protection is possible only as a result of full cooperation in the government and non-governmental

LOGISTIKOS PROCESŲ VALDYMO TYRIMO SOCIALINIŲ TINKLŲ KONCEPCIJA

In contemporary public management, especially in the New Public Governance model, the network paradigm is increasingly underlined, which results from the growing importance of inter-organisational relations in the effective functioning of public organisations. However, the subject literature lacks well-established research, both theoretical and empirical, aimed at determining the importance of the network paradigm in improving public management oriented on the needs of citizens as members of the political and territorial community. Moreover, the role of logistics management in improving the effectiveness of public sector organisations is increasingly recognized, which creates interest in researching this issue (Kożuch et al., 2018). This article is an attempt to fill this research gap by developing the concept of research on logistics management in public networks. The developed (1) a map of relations in public networks and (2) a public institution sub-network model shall be used to this end.  Socialinių paslaugų efektyvumo didinimo galimybių paieška sukuria logistikos procesų valdymo perspektyvas. Tačiau tyrimai šiuo klausimu atliekami atsitiktinai. Straipsnio tikslas – sukurti logistikos procesų valdymo socialinių tinklų tyrimo koncepciją. Atliekant analizę apibūdintas logistikos procesų valdymas ir socialiniai tinklai. Pagrindinis dėmesys skiriamas socialinių tinklų sudėtingumui ir problemoms, kurios lemia jų specifiškumą. Susipažinti su viešųjų tinklų ypatumais padeda suplanuotas socialinių tinklų santykių žemėlapis ir viešųjų institucijų pogrupių modelis. Šis straipsnis yra konceptualus ir jo rezultatas – nustatyti logistikos procesų valdymo socialiniame tinkle tyrimo kryptys ir tvarką

Logistikos procesų valdymo tyrimo viešųjų tinklų koncepcija

The search for possibilities to increase the efficiency of implementing public services creates prospects for the use of logistics management. However, research on this subject is sporadic. This has been the reason for undertaking research in this area and attempting to develop a concept for the re- search of logistics management in public networks, which is the purpose of this article. In the course of the analyses, logistic s management and public networks were characterised. The focus is on the complexity and problems of public networks, which determine their specificity. Getting to know pub- lic networks’ specifics is facilitated by the developed map of rel ations in public networks and the model of public institution sub - networks. The nature of this article is conceptual and its result is set- ting the directions and procedure of researching logistics management in public networks.Socialinių paslaugų efektyvumo didinimo galimybių paieška sukuria logistikos procesų val- dymo perspektyvas. Tačiau tyrimai šiuo klausimu atliekami atsitiktinai. Straipsnio tikslas – sukurti logistikos procesų valdymo socialinių tinklų tyrimo koncepciją. Atliekant analizę apibūdintas logis- tikos procesų valdymas ir socialiniai tinklai. Pagrindin is dėmesys skiriamas socialinių tinklų sudė- tingumui ir problemoms, kurios lemia jų specifiškumą. Susipažinti su viešųjų tinklų ypatumais pa- deda suplanuotas socialini ų tinklų santykių žemėlapis ir viešųjų institucijų pogrupių modelis. Šis straipsnis yra kon ceptualus ir jo rezultatas – nustatyti logistikos procesų valdymo socialiniame tink- le tyrimo kryptys ir tvarką

Why logistics in public management?

Współczesne trendy rozwoju logistyki wskazują na potrzebę i możliwości wykorzystania tej dziedziny w procesach świadczenia usług publicznych. Jednakże prowadzone w tym zakresie badania - zarówno w Polsce, jak i za granicą - koncentrują się jedynie na wybranych obszarach zarządzania publicznego, np. transporcie miejskim, ochronie zdrowia, czy też zarządzaniu kryzysowym. Początkowy etap rozwoju logistyki w zarządzaniu publicznym wyłonił dwa podejścia, a mianowicie logistykę publiczną i logistykę społeczną. Jednakże podejścia te nie są jeszcze w pełni rozwinięte. Istnieje też brak wyraźnej granicy pomiędzy nimi, a jednak brak jednoznacznego stwierdzenia, jakimi dokładnie problemami publicznymi i społecznymi się one zajmują. Występuje zatem luka badawcza i pilna potrzeba usystematyzowania wiedzy na temat implementacji logistyki w zarządzaniu publicznym. Próba wypełnienia części tej luki badawczej stanowi cel artykułu.Modern trends in logistics development indicate the need and possibility of using this area in the processes of providing public services. However, research conducted in this area - both in Poland and abroad - focuses only on selected areas of public management, e.g. urban transport, health care or crisis management. The initial stage of logistics development in public management has resulted in two approaches, namely public and social logistics. However, these approaches are not yet fully developed. There is also a lack of a clear line between them and a lack of a clear statement as to exactly which public and social problems they are dealing with. There is therefore a research gap and an urgent need to systematise knowledge on the implementation of logistics in public management. Attempting to fill a part of this research gap is the aim of the article

Modelling the risk-benefit impact of H1N1 influenza vaccines

BACKGROUND: Shortly after the H1N1 influenza virus reached pandemic status in June 2009, the benefit-risk project team at the European Medicines Agency recognized this presented a research opportunity for testing the usefulness of a decision analysis model in deliberations about approving vaccines soon based on limited data or waiting for more data. Undertaken purely as a research exercise, the model was not connected to the ongoing assessment by the European Medicines Agency, which approved the H1N1 vaccines on 25 September 2009. METHODS: A decision tree model constructed initially on 1 September 2009, and slightly revised subsequently as new data were obtained, represented an end-of-September or end-of-October approval of vaccines. The model showed combinations of uncertain events, the severity of the disease and the vaccines' efficacy and safety, leading to estimates of numbers of deaths and serious disabilities. The group based their probability assessments on available information and background knowledge about vaccines and similar pandemics in the past. RESULTS: Weighting the numbers by their joint probabilities for all paths through the decision tree gave a weighted average for a September decision of 216 500 deaths and serious disabilities, and for a decision delayed to October of 291 547, showing that an early decision was preferable. CONCLUSIONS: The process of constructing the model facilitated communications among the group's members and led to new insights for several participants, while its robustness built confidence in the decision. These findings suggest that models might be helpful to regulators, as they form their preferences during the process of deliberation and debate, and more generally, for public health issues when decision makers face considerable uncertainty