Scattering correction for samples with cylindrical domains measured with polarized infrared spectroscopy

Scattering artifacts are one of the most common effects distorting transmission spectra in Fourier-Transform Infrared spectroscopy. Their increased impact, strongly diminishing the quantitative and qualitative power of IR spectroscopy, is especially observed for structures with a size comparable to the radiation wavelength. To tackle this problem, a wide range of preprocessing techniques based on the Extended Multiplicative Scattering Correction method was developed, using physical properties to remove scattering presence in the spectra. However, until recently those algorithms were mostly focused on spherically shaped samples, for example, cells. Here, an algorithm for samples with cylindrical domains is described, with additional implementation of a linearly polarized light case, which is crucial for the growing field of polarized IR imaging and spectroscopy. An open-source code with GPU based implementation is provided, with a calculation time of several seconds per spectrum. Optimizations done to improve the throughput of this algorithm allow the application of this method into the standard preprocessing pipeline of small datasets

VALUE OF SPEED CAPABILITIES IN YOUTH SPEED CLIMBING AT HIGH SPORTS LEVEL

Current research on speed climbing at the senior level shows that speed capabilities are a significant factor determining climbing time. The main purpose of our research was to evaluate the level of speed capabilities among young speed climbers and to examine the relationship between the level of speed capabilities and the results achieved during an international competition. The subjects of the research were girls and boys in the following age categories: Female Youth A (age=16.6), Female Youth B (age=14.5 years), Male Youth A (age=16.87 years) and Male Youth B (age=14.8 years). Measurements of somatic features were included: body height, body weight, percentage of fat tissue and BMI. Speed capabilities were measured with Wingate Test. The significance test of differences showed no significant differentiation within climbing times between the groups of girls and the groups of boys. A strong correlation between climbing time and relative peak power was noticed in the Female Youth B group. The correlation between peak power and climbing time was lower in the other groups. Research showed that in speed climbing, as career progresses, it is importance of other factors rather than speed capabilities that may increase. It can be assumed that with an increase in training experience, motor skills become more essential.

PREDICTING PERFORMANCE IN SPEED CLIMBING: ACCURACY OF THE FORCE-VELOCITY TEST ON A CYCLE ERGOMETER

The present study examined the validity of the force-velocity (F-V) mechanical parameters of the lower limbs as a predictors of the competitive performance in junior male speed climbing. The second aim was to evaluate F-V characteristics in competitive speed climbers in the junior male category. Ten junior male speed climbers (age: 18±0.5 years; BH: 174.7±4.5 cm; BW: 66.4±6.6 kg; with mean best climbing time from the competition BCT: 7.29±0.66 s) were participants in the research. All they were participants in the Youth European Cup in speed climbing. F-V characteristics were measured using a cycle ergometer test according to the Vandewalle’s protocol. To evaluate of the validity between BCT (criterion) and mechanical parameters (practical measures) from F-V test a standard error of the estimate (expressed as a raw and standardized typical error, TE) and correlation coefficients (rx,y) were used. Moreover, the validity of BCT as a potentially predictor of final competition rank (as a criterion for BCT) was evaluated. Additionally the mean value and standard deviation were calculated for all measured variables. Validity of the BCT as a competition place predictor was largely overestimated (TE=0.73 and rx,y=0.81, p p≤0.05). Accuracy of the BCT prediction for somatic and mechanical variables were very largely error biased. The standardized values of TE for these variables were: 1.93÷7.25. The rx,y were in the range of -0.18 to -0.46. The level of the mechanical variables from the F-V cycle ergometer as a predictors of the BCT in speed climbing may be largely error biased. Application of the cycle ergometer F-V test of prediction BCT values in speed climbing may have low practical value. Moreover, BCT variable may be a poor predictor of the final competition result. Coaches should take these suggestions into account during preparations to speed climbing competitions.

General technical remarks on ^{1}HMRS translational research in 7T

Purpose: The aim of the work was to share the practical experience of preclinical and clinical proton magnetic resonance spectroscopy (1HMRS) studies conducted using a 7-Tesla magnetic field strength scanner, taking into account the specificity of both settings in the context of translational research. Material and methods: 1HMRS volunteer studies conducted using a Discovery 950 GE 7T scanner, were carried out with PRESS sequence, and a VOI measuring 2.0 × 2.0 × 2.0 cm3 placed in the white matter at the parietal occipital lobe. Rodent spectra obtained using a 7T Bruker were measured with PRESS, with a VOI 2.0 × 2.0 × 5.5 mm3 placed over the hippocampus. Results: 1HMRS data from humans and rats show that the brain spectra obtained in the same field are characterised by a similar neurochemical structure and spectral resolution. Spectra obtained from rats demonstrate the following metabolites: NAA, Glu, Gln, Ins, Cho, Cr, PCr, Tau, GABA, Lac, NAAG, and Asp. In turn, spectra from humans allowed estimation of the following metabolites: Ala, NAA, Glu, Gln, Ins, Cho, Cr, PCr, Tau, GABA, Lac, NAAG, and Asp. Signals from Gln, Glu with chemical shift around 2.4 ppm, from Cr, PCr, and GABA at 3 ppm, and signals from Cho and Tau at approximately 3.2 ppm, can be properly separated and estimated both in humans and in rats. Conclusions: These results are promising in terms of broadening the knowledge of many neurological diseases by inducing them on animal models and then transferring this knowledge to clinical practice. In spite of this, important distinctions in the technical aspects and methodological differences of high-field 1HMRS in both preclinical and clinical conditions should be taken into account

The importance of CAD and DECT in CT colonography

IntroductionAccording to the American College of Radiology and the American Cancer Society, CTC has been recognized as a valuable screening method for detecting CRC in people at medium risk as an alternative to endoscopic colonoscopy. The condition for the proper interpretation of this procedure is the patient’s preparation for the examination. The evaluation of the test includes: topogram, transverse images (as reference images), multifaceted reconstructions and three-dimensional images (3D navigator). Materials and methods                            The literature on the use of CTC in the diagnosis of CRC was analyzed. A review of the scientific literature indexed in the PUBMED database from the last 10 years was carried out. Results The introduction of dual energy computed tomography (DECT) clearly improved the diagnostic accuracy of CTC. The main advantage of DECT is the possibility of obtaining iodine maps and VNC (virtual non-contrast) – a ’’virtual’’ native image (without the use of contrast). DECT allows you to monitor the results and extent of iodine capture on VNC and iodine map images, respectively, without using pre-recorded tomographic images. Pilot tests showed that DECT is an effective tool in CT colonography diagnostics and electronic colon loop cleaning after barium labeling. The use of the Computer Aided Diagnosis (CAD) algorithm in high energy tomography helps in the diagnosis and detection of intestinal tumors. ConclusionsThe development of modern technologies used in CT colonography proves that it is a safe and acceptable technique for patients. Lack of invasiveness, low radiation dose and high diagnostic efficiency of CTC may encourage more people to undergo colorectal cancer screening in the future

Uwagi do projektu rozporządzenia Rady w sprawie małżeńskich ustrojów majątkowych (2011/0059) (CNS) z dnia 20 grudnia 2012 roku (uwagi dotyczą przepisów o prawie właściwym).

The opinion of the Civil Law and Private International Law Department in the Silesian University on the Proposal for a Council Regulation on jurisdiction, applicable law and the recognition and enforcement of decisions in matters of matrimonial property regimes (on December 20-th, 2012) is presented in the paper. The text focuses on conflict of law issues. The most important changes are proposed in art. 19, 20, 20b, 22. The most difficult issue to be solved is connected with the effect of matrimonial property regime in respect of third parties. This problem cannot be solved without the introduction of the European common register of matrimonial property regimes. The proposal of the formal requirements of a matrimonial property agreement is also criticized. The form of the agreement should be regulated separately in the Regulation without referral to the national legal systems. It should also ensure the objective information of the date of the agreement (for example official certification of the date)

Endometriosis and an increased risk of malignancies

Introduction: Endometriosis is a common gynaecological disorder associated with pelvic pain and sub-fertility, affecting 7–15% of women of reproductive age. The disease is defined as the presence of endometrial-like tissue outside the uterine cavity, primarily on pelvic organs. The aetiology of endometriosis is still uncertain. The disease rarely causes mortality, however, it may have a significant impact on a patient's quality of life. Moreover, several studies have consistently shown that endometriosis is associated with a higher risk of some types of malignancies.Results: Endometriosis shares several molecular characteristics with invasive cancer, such as inflammation, tissue invasion, angiogenesis, dysfunction of immune cells and pro-survival features. Studies have shown that ovarian cancer, especially clear cell, endometrioid and serous, has been associated with endometriosis. Furthermore, the risk of cancer of the uterine cervix has shown to be decreased and the results on the risk of the cancers of uterine corpus or breast are inconsistent. Among non‐gynecological cancers, melanoma of the skin, non‐Hodgkin‐lymphoma, brain and thyroid cancers have also been associated with endometriosis.Conclusions: Research results indicate that women with endometriosis have an increased risk for some types of malignancies, therefore, they should be under strict gynecological control, even many years after menopause. Further research is needed to prove the real risk of different types of malignant tumors among women with endometriosis. In addition, it is necessary to establish periodic examination schedules among these patients in order to prevent certain types of malignancies

Design and synthesis of new quinazolin-4-one derivatives with negative mGlu7mGlu_7 receptor modulation activity and antipsychotic-like properties

Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu7 NAMs, we synthesized a new compound library containing 103 members, which were examined for NAM mGlu7 activity in the T-REx 293 cell line expressing a recombinant human mGlu7 receptor. Out of the twenty-two scaffolds examined, active compounds were found only within the quinazolinone chemotype. 2-(2-Chlorophenyl)-6-(2,3-dimethoxyphenyl)-3-methylquinazolin-4(3H)-one (A9-7, ALX-171, mGlu7 IC50 = 6.14 µM) was selective over other group III mGlu receptors (mGlu4 and mGlu8), exhibited satisfactory drug-like properties in preliminary DMPK profiling, and was further tested in animal models of antipsychotic-like activity, assessing the positive, negative, and cognitive symptoms. ALX-171 reversed DOI-induced head twitches and MK-801-induced disruptions of social interactions or cognition in the novel object recognition test and spatial delayed alternation test. On the other hand, the efficacy of the compound was not observed in the MK-801-induced hyperactivity test or prepulse inhibition. In summary, the observed antipsychotic activity profile of ALX-171 justifies the further development of the group of quinazolin-4-one derivatives in the search for a new drug candidate for schizophrenia treatment