Irritable bowel syndrome

Приведены данные литературы по проблеме синдрома раздраженной кишки, а также результаты собственных исследований, которые свидетельствуют о целесообразности применения медикаментозного комплекса — ЭГЛОНИЛ, НО-ШПА форте, МАГНЕ-Вл — для лечения больных с синдромом раздраженной кишки с повышенным газообразованием и абдоминальной болью при наличии соматоформныхрасстройств в виде тревожно-депрессивных состояний ; Наведені дані літератури з проблеми синдрому подразненої кишки, а також результати власних досліджень, які свідчать про доцільність застосування медикаментозного комплексу — ЕГЛОНІЛ. НО-ШПА форте і МАГНЕ-В6 — для лікування хворих із синдромом подразненої кишки з підвищеним газоутворенням та абдомінальним болем за наявності соматоформних розладів у вигляді тривожно- депресивних станів ; Article represents literature data on the problem of irritable bowel syndrome as well as native data that are substantiate the practicability of application of the complex of medicines — EGLONIL, NO-SPA forte. MAGNE-Bf, — in patients with irritable bowel syndrome with increased gas formation and abdominal pain on the background of anxiety-depression somatoform disorders

Пространственно-временнáя изменчивость снегонакопления на Западном плато Эльбруса (Центральный Кавказ)

Cold glaciers in the middle latitudes are considered unique archives of environmental and climate change. However, alpine ice cores are difficult to interpret, since dynamic changes can occur over very short distances. Detailed radar survey can be used to assess the effect of ice inflow from areas with different conditions of snow accumulation on the surface compared to the drilling point on the isotopic and chemical record in the glacier core. The results of radar studies on the Western plateau of Elbrus (Central Caucasus), located at an altitude of 5100–5150 m above sea level, are presented. A high-frequency ground-based radar survey was carried out in the summer of 2017 to assess the spatial and temporal changes in snow accumulation in the upper (near the top area) part of Elbrus. The ZOND 12-e GPR (ground-penetrating radar, Radar Systems, Inc.) with 500 and 300 MHz shielded antennas was used. The receiving time window was set to 100 ns (500 MHz antenna) and 470 ns (300 MHz) to obtain reflection in the depth range of about 10 m and 50 m, respectively. The results of the GPR sounding are confirmed by data on the stratigraphy, density and chemical composition of the snow-firn thickness from a shallow (24 m) borehole. The density profile made it possible to identify peaks and corresponding ice crusts of 1–2 cm thick that formed during warm periods. The internal reflections, clearly visible on the radar profiles up to 50 m deep, are of isochronous origin and have been interpreted as the boundaries of annual and seasonal layers. Detailed maps of the distribution of snow accumulation covering the cold and warm seasons of 2015–2017 have been obtained. The average thickness of seasonal snow cover on the plateau during this period was equal to 2.07 m, with minimum and maximum values of 0.2 and 3.9 m, respectively. The average values of the water storage in seasonal horizons range from 754 to 1126 mm W.E., while the annual accumulation for the 2015/16 and 2016/17 balance years amounted to 2004 and 1874 mm W.E., respectively. The data obtained were used in 2018 to determine the optimal location for deep core drilling and will further serve as the basis for modeling the age of ice on the Western Plateau of Elbrus.По данным наземного высокочастотного радиозондирования летом 2017 г. на Западном ледниковом плато Эльбруса (Центральный Кавказ) установлено, что аккумуляция снега в привершинной области характеризуется значительной изменчивостью, а также имеет сезонные различия. Анализ полей аккумуляции показал, что в средней части плато снега накапливается меньше, чем в восточной и западной, но распределение снега по площади плато аналогично из года в год. В тёплый период снегонакопление в среднем больше, чем в холодный, и происходит оно более равномерно по площади плато

Пути дальнего переноса пыли на ледники Кавказа и химический состав снега на Западном плато Эльбруса

We present and discuss the chronology of dust deposition events documented by the shallow firn and ice cores extracted on the Western Plateau, Mt. Elbrus (5150 m a.s.l.) in 2009, 2012 and 2013. Snow and ice samples were analysed for major ions and minor element concentrations including heavy metals. Dust layers are formed on the surface of the glaciers as a result of atmospheric transport of mineral dust and aerosol particles to the Caucasus region. Satellite imagery (SEVIRI), trajectory models, and meteorological data were used for accurate dating of each the dust layers revealed in the ice cores. Then we tried to determine origins of the dust clouds and to investigate their transport pathways with high resolution (50–100 km). It was found that the desert dust is deposited on Caucasus glaciers 3–7 times in a year and it comes mainly from deserts of the Middle East and more rarely from the Northern Sahara desert. For the first time average annual dust flux (264 µg/cm2 per a year) and average mass concentration (1.7 mg/kg) over the period 2007–2013 were calculated for this region. The deposition of dust resulted in elevated concentrations consists of mostly ions, especially Ca2+, Mg2+, K+, and sulphates. Dust originated from various sources in the Middle East, including Mesopotamia, or similar dust clouds passing over the Middle East are characterised by high concentrations of nitrates and ammonia that may be related to atmospheric transport of ammonium from agricultural lands that may explain high concentrations of ammonium in the dust originating from this region. Mean values of crustal enrichment factors (EF) for the measured minor elements including heavy metals were calculated. We believe that high content of Cu, Zn and Cd can be a result of possible contribution from anthropogenic sources. Studies of the Caucasus ice cores may allow obtaining new independent data on the atmosphere circulation and high-altitude environment of this region.Исследованы образцы из снежных шурфов и керна из неглубоких скважин, пробуренных на Западном плато Эльбруса на высоте 5100 м в 2009, 2012 и 2013 гг. Образцы снега и льда проанализированы на содержание основных соединений и микроэлементов, включая тяжёлые металлы. В результате переноса минеральных частиц на ледники Кавказа в снежно-фирновой толще формируются отчётливо различимые горизонты загрязнения. Анализ космических снимков SEVIRI, полей оптической толщины атмосферы, траекторий движения воздушных масс и метеорологических данных позволил определить первичные источники минеральных частиц для переноса пыли с высокой точностью (50–100 км). Cоставлена хронология событий переноса пыли. Установлено, что такие явления происходят на Кавказе 3–7 раз в год. Пыль принесена на ледники Эльбруса с Ближнего Востока и из Северной Африки. Выполнено первое для Кавказа прямое определение количества твёрдого вещества, выпадающего из атмосферы на поверхность на больших высотах – 264 мкг/см2 в год. Химический анализ образцов снега из горизонтов загрязнения, образовавшихся в 2009 г., показал высокое содержание нитратов, аммония и сульфатов, что связано с поступлением пыли из сельскохозяйственных районов в Месопотамии. Обнаружено повышенное содержание Cu, Zn и Cd по сравнению с естественным фоном, что может указывать на повышенный региональный фон этих элементов в Северной Африке и на Ближнем Востоке, а также на вероятный вклад антропогенных аэрозолей.

Investigation of plasma turbulence and local electric field in the T-10 tokamak and TJ-II stellarator by HIBP diagnoatic(review)

TJ-II stellarator by HIBP diagnostics has been performed. The following similar features of potential were found: the scale of several hundred Volts; the negative sign for densities ne>1×10¹⁹ m⁻³ and comparable values in spite of the different heating methods. When ne or tE rises, the potential evolves to negative values. During ECR heating and associated Te rise, tE degrades and the potential evolves to positive direction. Oscillations of potential and density in the range of Geodesic Acoustic Modes in T-10 and Alfvén Eigenmodes in TJ-II were observed.На токамаці Т-10 і стелараторі TJ-II за допомогою пучка важких іонів в порівняних режимах досліджувалася поведінка потенціалу та його флуктуацій. Виявлені спільні властивості потенціалу: масштаб близько сотен вольт;негативний знак при щільності ne>1×10¹⁹ m⁻³ і порівнянні значення, незважаючи на різні методи нагріву. Коли n_е або t_Е зростають, потенціал зростае у негативну область. При ЕЦР-нагріві і відповідному рості Te, t_Е погіршується, і потенціал змінюється у позитивний бік. Спостерігається коливання потенціалу в діапазоні геодезичних акустичних мод у Т-10 та альфвеновських власних мод у TJ-IIНа токамаке Т-10 и стеллараторе TJ-II с помощью пучка тяжелых ионов в сравнимых режимах исследовалось поведение потенциала и его флуктуаций. Обнаружены общие свойства потенциала: масштаб порядка сотен вольт; отрицательный знак при плотностях n_е>1×10¹⁹ m⁻³ и сравнимые значения, несмотря на разные методы нагрева. Когда n_е или t_Е растут, потенциал растет в отрицательную область. При ЭЦР-нагреве и соответствующем росте Te, t_Е ухудшается, и потенциал меняется в положительную сторону. Наблюдались колебания потенциала в диапазоне геодезических акустических мод в Т-10 и альфвеновских собственных мод в TJ-I

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presented. ISSN:0029-5515 ISSN:1741-432

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F