Economic Galileo E5 Receiver

The Galileo system introduces an extremely wideband civil E5 signal for high precision navigation. The structure of the receiver for the E5 signal is complicated due to the signal complexity and the large bandwidth. It is possible to process the whole E5 signal or process separately E5a and E5b parts combining obtained results afterwards (we call here such method as piece-wise processing). The second procedure has three times worse standard deviation of the pseudorange then first one. The main goal of the paper is to present a design of an E5 receiver which we will call the economic E5 receiver (ecoE5). It is built from jointly controlled correlators for the processing of the E5a and E5b signals which are parts of the E5 signal. Control of these partial E5a and E5b correlators is realized by only one delay and one phase lock loops. The performance, i.e. the pseudorange noise and multipath errors, of the receiver equipped with the ecoE5, is only slightly worse (the standard deviation of the pseudorange noise is 10 - 20% larger) than the performance of the optimal E5 receiver and it is much better than the performance of the receiver combining the piecewise (E5a and E5b) measurements. The ecoE5 receiver hardware demands are about one quarter of the hardware demands of the classical E5 receiver

Universality and Realistic Extensions to the Semi-Analytic Simulation Principle in GNSS Signal Processing

Semi-analytic simulation principle in GNSS signal processing bypasses the bit-true operations at high sampling frequency. Instead, signals at the output branches of the integrate&dump blocks are successfully modeled, thus making extensive Monte Carlo simulations feasible. Methods for simulations of code and carrier tracking loops with BPSK, BOC signals have been introduced in the literature. Matlab toolboxes were designed and published. In this paper, we further extend the applicability of the approach. Firstly, we describe any GNSS signal as a special instance of linear multi-dimensional modulation. Thereby, we state universal framework for classification of differently modulated signals. Using such description, we derive the semi-analytic models generally. Secondly, we extend the model for realistic scenarios including delay in the feed back, slowly fading multipath effects, finite bandwidth, phase noise, and a combination of these. Finally, a discussion on connection of this semi-analytic model and position-velocity-time estimator is delivered, as well as comparison of theoretical and simulated characteristics, produced by a prototype simulator developed at CTU in Prague

A Multiplexer/Demultiplexer System for the Multi-Color Spin-Scan Cloud Camera on ATS-C

The ATS-3 spacecraft has transmitted many high quality color pictures of the full earth disc. This paper describes the design of the multiplexing/demultiplexing system for the multi-color camera. This system, which employs time division multiplexed pulse amplitude modulation (PAM), is described from a block diagram standpoint. Circuit design highlights and packaging details are also provided, Finally, the test results of the actual equipment are given

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells.

CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized. We employed gene knockdown and rescue assays to explore the consequences of altered CEBPB gene expression in Ewing sarcoma cell lines. Knockdown of EWS-FLI1 expression led to a decrease in expression of all three C/EBPβ isoforms while re-expression of EWS-FLI1 rescued C/EBPβ expression. Overexpression of C/EBPβ-1, the largest of the three C/EBPβ isoforms, led to a significant increase in colony formation when cells were grown in soft agar compared to empty vector transduced cells. In addition, depletion of C/EBPβ decreased colony formation, and re-expression of either C/EBPβ-1 or C/EBPβ-2 rescued the phenotype. We identified the cancer stem cell marker ALDH1A1 as a target of C/EBPβ in Ewing sarcoma. Furthermore, increased expression of C/EBPβ led to resistance to chemotherapeutic agents. In summary, we have identified CEBPB as an oncogene in Ewing sarcoma. Overexpression of C/EBPβ-1 increases transformation, upregulates expression of the cancer stem cell marker ALDH1A1, and leads to chemoresistance

Livestock grazing and vegetative filter strip buffer effects on runoff sediment, nitrate, and phosphorus losses

Livestock grazing in the Midwestern United States can result in significant levels of runoff sediment and nutrient losses to surface water resources. Some of these contaminants can increase stream eutrophication and are suspected of contributing to hypoxic conditions in the Gulf of Mexico. This research quantified effects of livestock grazing management practices and vegetative filter strip buffers on runoff depth and mass losses of total solids, nitrate-nitrogen (NO3-N), and ortho-phosphorus (PO4-P) under natural hydrologic conditions. Runoff data were collected from 12 rainfall events during 2001 to 2003 at an Iowa State University research farm in central Iowa, United States. Three vegetative buffers (paddock area:vegetative buffer area ratios of 1:0.2, 1:0.1, and 1:0 no buffer [control]) and three grazing management practices (continuous, rotational, and no grazing [control]) comprised nine treatment combinations (vegetative buffer ratio/grazing management practice) replicated in three 1.35 ha (3.34 ac) plot areas. The total 4.05 ha (10.02 ac) study area also included nine 0.4 ha (1.0 ac) paddocks and 27 vegetative buffer runoff collection units distributed in a randomized complete block design. The study site was established on uneven terrain with a maximum of 15% slopes and consisted of approximately 100% cool-season smooth bromegrass. Average paddock and vegetative buffer plant tiller densities estimated during the 2003 project season were approximately 62 million and 93 million tillers ha−1 (153 million and 230 million tillers ac−1), respectively. Runoff sample collection pipe leakage discovered and corrected during 2001 possibly reduced runoff depth and affected runoff contaminant mass losses data values. Consequently, 2001 runoff analysis results were limited to treatment comparisons within the 2001 season and were not compared with 2002 and 2003 data. Analysis results from 2001 showed no significant differences in average losses of runoff, total solids, NO3-N, and PO4-P among the nine vegetative buffer/grazing practice treatment combinations. Results from 2002 indicated significantly higher losses of runoff and total solids from 1:0 no buffer/rotational grazing and 1:0 no buffer/continuous grazing treatment combination plots, respectively, compared among other 2002 season treatment combinations. The 2003 results showed significantly higher runoff and total solids losses from 1:0 no buffer/no grazing treatment combination plots compared among all 2003 treatment combinations and from 1:0.1 vegetative buffer/no grazing treatment combination plots compared among all 2003 treatment combinations and with respective 2002 treatment combinations. However, the 2003 results indicated effective vegetative buffer performance with significantly lower runoff, total solids, and NO3-N losses from the larger 1:0.2 buffer area compared among the smaller 1:0.1 buffer area and 1:0 no buffer treatment combinations. The 2003 results also indicated a highly significant increase in losses of NO3-N from 1:0.1 buffer/no grazing treatment combination plots compared among other 2003 season treatment combinations and with respective 2002 treatment combinations. Overall results from this study suggest a shift from significantly higher 2002 season plot losses of continuous and rotational grazing treatment combinations to significantly higher 2003 season losses of no grazing treatment combinations. We speculate this shift to significantly higher runoff and contaminant losses from no grazing treatment combination plots during 2003 reflects the variability inherent to a complex and dynamic soil-water environment of livestock grazing areas. However, we also hypothesize the environmental conditions that largely consisted of a dense perennial cool-season grass type, high-relief landscape, and relatively high total rainfall depth may not necessarily include livestock grazing activities

Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium

Background<p></p> Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.<p></p> Methods and Results<p></p> We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).<p></p> Conclusion<p></p> Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings

Oscillations above the barrier in the fusion of 28Si + 28Si

Fusion cross sections of 28Si + 28Si have been measured in a range above the barrier with a very small energy step (DeltaElab = 0.5 MeV). Regular oscillations have been observed, best evidenced in the first derivative of the energy-weighted excitation function. For the first time, quite different behaviors (the appearance of oscillations and the trend of sub-barrier cross sections) have been reproduced within the same theoretical frame, i.e., the coupled-channel model using the shallow M3Y+repulsion potential. The calculations suggest that channel couplings play an important role in the appearance of the oscillations, and that the simple relation between a peak in the derivative of the energy-weighted cross section and the height of a centrifugal barrier is lost, and so is the interpretation of the second derivative of the excitation function as a barrier distribution for this system, at energies above the Coulomb barrier.Comment: submitted to Physics Letters

Tests of a large air‐core superconducting solenoid as a nuclear‐reaction‐product spectrometer

An air‐core superconducting solenoid, with a diameter of 0.2 m and a length of 0.4 m, has been configured for use as a heavy‐ion reaction‐product spectrometer (E/A≤5 MeV/u) near θ=0° (10 to 35 msr). The performance of the spectrometer was established using α‐particle sources and nuclear‐reaction products from (18O, 18Ne), (18O, 20Ne) and (18O, 14O) and masses determined for 30Mg, 108Ru and 109Rh. A system suitable for production of radioactive beams has been constructed, and in‐beam tests are in progress at the University of Notre Dame. Large air‐core solenoids with dΩ≤20 msr and capable of focusing ions with E/A≥30 MeV/u appear feasible.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87304/2/845_1.pd