218 research outputs found

    Exile Vol. XLIX

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    47th Year Title Page 3 Epigraph by Ezra Pound 5 Table of Contents 7 Contributors\u27 Notes 62-63 Editorial Board 64 ART Hidden by Elizabeth Averbeck \u2704 8 Untitled by Laura Cannon \u2705 10 Untitled by Matt Messmer \u2706 16 Hierve el agua by Emily stenken \u2703 18 A Late One by Sarah R. Smith \u2703 27 Between the Lines by Gregory Holden \u2703 30 Carwash by Gregory Holden \u2703 40 Untitled by Laura Cannon \u2705 42 Flowers in Her Hair by Gregory Holden \u2703 53 Untitled Forrest by Jessica Kramer \u2703 56 POETRY What the Dead Had Grown by Steve Kovach \u2703 9 European Affairs by Ginna Fuselier \u2703 17 Combing the Everglades by Scott Barsotti \u2703 28-29 Persecution by Steve Kovach \u2703 41 A few coins in a styrofoam cup by Miranda Bodfish \u2705 54-55 FICTION Here\u27s to Mary by Katie Mannel \u2705 11-15 The Game of Right by Bradley Prefling \u2703 19-26 The Interview by Nicole Bennett \u2704 31-39 Jet Black Chevrolet by Scott Barsotti \u2703 43-52 Fulfilling Duty by Daniel Kinicki \u2705 57-61 All submissions are reviewed on an anonymous basis, and all editorial decisions are shared equally among the members of the Editorial Board. -64 Cover Art Despair by Gregory Holden \u2703 / Back Cover Art Untitled by Laura Cannon \u2705 -64 Printing by Printing Arts Press -64 Scott Barsotti, Jet Black Chevrolet redacted due to copyright restrictions

    Anti-VEGF Treatment Strategies for Wet AMD

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    Over the past few years, antivascular endothelial growth factor (VEGF) therapy has become a standard treatment for neovascular age-related macular degeneration (AMD). During this time, treatment strategies have evolved from a monthly dosing schedule to individualized regimens. This paper will review the currently available anti-VEGF agents and evidence-based treatment strategies

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    Coherent light scattering by nanostructured collagen arrays in the caruncles of the Malagasy asities (Eurylaimidae : Aves)

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    We investigated the anatomy, nanostructure and biophysics of the structurally coloured facial caruncles of three species in a clade of birds endemic to Madagascar (Philepittinae, Eurylaimidae: Aves), Caruncle tissues of all species had reflectance spectra with prominent, peak hues between 403 and 528 nm, Dark blue Neodrepanis tissues had substantial reflectance in the near ultraviolet (320-400 nm), which is visible to birds but not to humans, providing the first evidence of ultraviolet skin colours in birds and the first indications of the possible function of ultraviolet skin colours in avian communication, These structural colours are produced by coherent scattering from arrays of parallel collagen fibres in the dermis, Tissues of Philepitta castanea were organized into hexagonal, crystal-like arrays, whereas Neodrepanis tissues were quasiordered, Predictions of the peak hues of reflectance (lambda(max)) using Bragg's law were relatively accurate, but Bragg's law requires physical assumptions that are obviously violated by these structures. A two-dimensional discrete Fourier analysis of the spatial variation in refractive index within the tissues documented that all the tissues are substantially nanostructured at the appropriate spatial scale to scatter visible light coherently. Predicted reflectance spectra based on the two-dimensional Fourier power spectra are relatively accurate at predicting the hue and shape of the reflectance spectra of the tissues. These results confirm that the nanostructure of the collagen arrays determines the colours that are coherently scattered by these tissues, The evolution of the anatomy and nanostructure of asity caruncles is discussed

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    Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards

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    Pain is underdetected and undertreated in people with dementia. We aimed to investigate the prevalence of pain in people with dementia admitted to general hospitals and explore the association between pain and behavioural and psychiatric symptoms of dementia (BPSD). We conducted a longitudinal cohort study of 230 people, aged above 70, with dementia and unplanned medical admissions to 2 UK hospitals. Participants were assessed at baseline and every 4 days for self-reported pain (yes/no question and FACES scale) and observed pain (Pain Assessment in Advanced Dementia scale [PAINAD]) at movement and at rest, for agitation (Cohen–Mansfield Agitating Inventory [CMAI]) and BPSD (Behavioural Pathology in Alzheimer Disease Scale [BEHAVE-AD]). On admission, 27% of participants self-reported pain rising to 39% on at least 1 occasion during admission. Half of them were able to complete the FACES scale, this proportion decreasing with more severe dementia. Using the PAINAD, 19% had pain at rest and 57% had pain on movement on at least 1 occasion (in 16%, this was persistent throughout the admission). In controlled analyses, pain was not associated with CMAI scores but was strongly associated with total BEHAVE-AD scores, both when pain was assessed on movement (b 5 0.20, 95% confidence interval [CI] 5 0.07- 0.32, P 5 0.002) and at rest (b 5 0.41, 95% CI 5 0.14-0.69, P 5 0.003). The association was the strongest for aggression and anxiety. Pain was common in people with dementia admitted to the acute hospital and associated with BPSD. Improved pain management may reduce distressing behaviours and improve the quality of hospital care for people with dementia
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