Simultaneous appearance of leukemoid reaction and phlegmasia cerulea dolens

A leukemoid reaction is an extreme form of reactive leukocytosis defined as granulocytic leukocytosis above 50 7 109/L produced by normal bone marrow, mostly in response to systemic infection or cancer. The mechanism as to how the haematopoetic system is altered to elevate production of myeloid cells is not known. A 69-year-old man presented with phlegmasia cerulea dolens caused by massive iliofemoral thrombosis. His workout at admission revealed absolute white blood cell count of 73.4 7 109/L, with neutrophil granulocyte of 68.5 7 109/L. The new increase in white blood cell count happened at day 5 after admission, when the haematoma of the anteromedial thigh was evacuated in general anaesthesia. There was a gradual decrease in counts until they reached the normal range. Deteriorated general condition with signs of systemic inflammatory response syndrome improved with supportive therapy, and the patient was discharged from hospital after 30 days. During hospitalization we did not identify any infectious focus, or any malignancy. We could not exclude other occult chronic conditions (malignancy) but the patient did not develop any other condition during 4.5 years of follow-up

Normal Rack Grid Generation Method for Screw Machines with Large Helix Angles

Improving the efficiency of the screw machine is highly significant for industry. Numerical simulation is an important tool in developing these machines. The 3D computational fluid dynamic simulation can give a valuable insight into the flow parameters of screw machines. However, it is currently difficult to generate high quality computational grids required for screw rotors with large helix angle. This is mainly due to the excessively high cell skewness of the rotors with large helix angel, which would introduce errors in numerical simulation. This paper presents a novel grid generation algorithm used for the screw rotors with large helix angel. This method is based on the principles developed for the grid generation in transverse cross-section. Such mesh is generated by SCORGTM using normal rack grid generation method which means numerical meshes are generated in a plane normal to the pitch helix line. The mesh lines are then parallel to the helix line and thus an orthogonal mesh will be produced. The main flow and leakage flow directions are orthogonal to the mesh, potentially reducing numerical diffusion. This developed algorithm could also be employed for single screw machines

Numerical modelling of twin-screw pumps based on computational fluid dynamics

Increasing demands for high-performance screw pumps in oil and gas as well as other applications require deep understanding of the fluid flow field inside the machine. Important effects on the performance such as dynamic losses, influence of the leakage gaps and presence and extent of cavitation are difficult to observe by experiments. However, it is possible to study such effects using well-validated computational fluid dynamics models. The novel-structured numerical mesh consisting of a single-computational domain for moving screw pump rotors was developed to allow three-dimensional computational fluid dynamics simulation of such machine possible. Based on finite volume method, the instantaneous mass flow rates, rotor torque, local pressure field, velocity field and other performance indicators including the indicated power were predicted. A calculation model for the bearing friction losses was introduced to account for mechanical losses. The geometry of the inlet and outlet passages and piping system are taken into consideration to evaluate their influences on the pressure distribution and shaft power. The paper also shows the influence of rotor clearances on the pump performance. The computational fluid dynamics model was validated by comparing the numerical results with the measured performance obtained in the experimental test rig through the comprehensive experiment performed for a set of discharge pressures and rotational speeds. Validation includes comparison of mass flow rates, shaft power and efficiency under variety of speeds and discharge pressure. It has been found that the predicted results match well with the measurements. The results also showed that the radial clearances have larger influence on the mass flow rate than the interlobe clearance. The correct design of the flow passages within the screw pump plays significant role in minimizing required power consumption. The analysis presented in this paper contributes to better understanding of the working process inside the screw pump and offers a good reference to improve design and optimize such machines in terms of clearance selection, shape of the ports, piping system, etc. In future, this model will be used for analysis of cavitating flows and determining performance of other multiphase screw pumps

Grid Generation for Screw Compressors with Variable Geometry Rotors

An algebraic grid generation algorithm is presented in this paper which enables the per- formance of twin screw compressors with variable rotor geometry to be predicted, by means of Computational Fluid Dynamics (CFD). It is based on a method, previously developed by the authors, for compressors with standard uniform pitch rotors and con- stant cross-section profile, which has now been extended to include rotors with variable pitch and/or variable profile. By its use with the commercial CFD solver ANSYS CFX, it has been possible to obtain performance predictions for three variants of an oil-free 3/5 screw compressor, namely uniform helical rotors, variable pitch rotors and variable profile rotors. The variable pitch and variable profile rotors achieve steeper internal pres- sure rise and a larger discharge area for the same pressure ratio. Variable pitch rotors also showed lower leakage rates due to reduced sealing line length in the high pressure domain. This grid generating procedure advances the ability to evaluate both existing and novel compressor configurations

Numerical investigation of oil injection in a Roots blower operated as expander

The adoption of positive displacement machines as expanders in Organic Rankine Cycles (ORCs) is increasingly common, especially in the low to medium power range. At the same time, these devices often serve as compressor in Vapor-Compression Refrigeration Systems. In both cases, the application of Computation Fluid Dynamics (CFD) to optimize such machines has become an integrated tool in the design process. As a consequence, several challenges associated with the numerical simulation have to be taken into account. For example, the modeling of the gap represents a challenge for the stability of the numerical analysis. The dynamic of the process, combined with deformations of the clearances and of the working chamber has to be considered with extra care. To raise the efficiency of the machine, oil is typically injected. Its numerical modeling imply an extra challenge in the simulation of the actual operation of the machine. The present work is mainly focused on the multi-phase nature of the flow, with a particular analysis of the lubricant oil injected. In this work, a two-lobe Roots blower operated as expander has been simulated with the open-source software OpenFOAM-v1812, using the SCORG-V5.2.2. This analysis highlights the areas that are affected the most by the oil presence in order to highlight the sealing effect it provides

Efficient computation of partial elements in the full-wave surface-peec method

The partial element equivalent circuit (PEEC) method provides an electromagnetic model of interconnections and packaging structures in terms of standard circuit elements. The surface-based PEEC (S-PEEC) formulation can reduce the number of unknowns compared to the standard volume-based PEEC (V-PEEC) method. This reduction is of particular use in the case of high-speed circuits and high-switching power electronics, where the bandwidth extends from low frequencies to the GHz range. In this article, the S-PEEC formulation is revised and cast in a matrix form. The main novelty is that the interaction integrals involving the curl of the magnetic and electric vector potentials are computed through the Taylor series expansion of the full-wave Green’s function, leading to analytical forms that are rigorously derived. Therefore, the numerical integration is avoided, with a consequent reduction of the computation time. The proposed formulas are studied in terms of the frequency, size of the mesh, and distance between the basis function domains. Three examples are presented, confirming the accuracy of the proposed method compared to the V-PEEC method and surface-based numerical methods from literature

The PULSE@Parkes project: A new observing technique for long-term pulsar monitoring

The PULSE@Parkes project has been designed to monitor the rotation of radio pulsars over time spans of days to years. The observations are obtained using the Parkes 64-m and 12-m radio telescopes by Australian and international high school students. These students learn the basis of radio astronomy and undertake small projects with their observations. The data are fully calibrated and obtained with the state-of-the-art pulsar hardware available at Parkes. The final data sets are archived and are currently being used to carry out studies of 1) pulsar glitches, 2) timing noise, 3) pulse profile stability over long time scales and 4) the extreme nulling phenomenon. The data are also included in other projects such as gamma-ray observatory support and for the Parkes Pulsar Timing Array project. In this paper we describe the current status of the project and present the first scientific results from the Parkes 12-m radio telescope. We emphasise that this project offers a straightforward means to enthuse high school students and the general public about radio astronomy while obtaining scientifically valuable data sets.Comment: accepted for publication by PAS

Correlation of changes in patient-reported quality of life with physician-rated global impression of change in patients with narcolepsy participating in a clinical trial of sodium oxybate : a post hoc analysis

Introduction: Narcolepsy patients report lower health-related quality of life (HRQoL) than the general population, as measured by the Short Form-36 Health Survey (SF-36). This analysis evaluated whether changes in SF-36 correlated with physician-rated Clinical Global Impression of Change (CGI-C). Methods: Data were from 209 of 228 narcolepsy patients participating in an 8-week clinical trial of sodium oxybate. Changes from baseline for SF-36 subscales (Physical Functioning, Role Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role Emotional, and Mental Health) and the summary scores were evaluated for correlation with CGI-C overall and by treatment group. Correlations were calculated using the Pearson product-moment correlation coefficient (r). Results: Correlations described an inverse relationship in scores, but a direct relationship in improvement; lower CGI-C scores (i.e., better) were associated with higher SF-36 subscale scores (i.e., improved HRQoL). Moderate and significant correlations were observed for Vitality (r = -0.464; P\0.0001) and Role Physical (r = -0.310; P\0.0001) subscales, but weak correlations were observed with other subscales including summary scores. Correlations were stronger at higher sodium oxybate doses for most SF-36 subscales. Conclusion: Some aspects of HRQoL, measured by the SF-36, may be associated with narcolepsy. In particular, Vitality (indicative of energy and tiredness) and Role Physical (impact of physical function on daily roles) moderately correlated with overall change in status observed by clinicians. However, lack of strong correlations between SF-36 and CGI-C indicates differences in patient and clinician perspectives of disease, and suggest a need for broader assessment of the impact of narcolepsy and its treatment on patients