Digital Signal Processing for the Multi-Bunch LHC Transverse Feedback System

For the LHC a VME card has been developed that contains all functionalities for transverse damping, diagnostics and controlled bunch by bunch excitation. It receives the normalized bunch by bunch position from two pick-ups via Gigabit Serial Links (SERDES). A Stratix II FPGA is responsible for resynchronising the two data streams to the bunch-synchronous clock domain (40.08 MHz) and then applying all the digital signal processing: In addition to the classic functionalities (gain balance, rejection of closed orbit, pick-up combinations, one-turn delay) it contains 3- turn Hilbert filters for phase adjustment with a single pickup scheme, a phase equalizer to correct for the non-linear phase response of the power amplifier and an interpolator to double the processing frequency followed by a low-pass filter to precisely control the bandwidth. Using two clock domains in the FPGA the phase of the feedback loop can be adjusted with a resolution of 10 ps. Built-in diagnostic memory (observation and post-mortem) and excitation memory for setting-up are also included. The card receives functions to continuously adjust its parameters as required during injection, ramping and physics

LHC Transverse Feedback System and its Hardware Commissioning

A powerful transverse feedback system ("Damper") has been installed in LHC. It will stabilise coupled bunch instabilities in a frequency range from 3 kHz to 20 MHz and at the same time damp injection oscillations originating from steering errors and injection kicker ripple. The transverse damper can also be used as an exciter for purposes of abort gap cleaning or tune measurement. The power and lowlevel systems layouts are described along with results from the hardware commissioning. The achieved performance is compared with earlier predictions and requirements for injection damping and instability control

LHC Transverse Feedback System: First Results of Commissionning

A powerful transverse feedback system ("Damper") has been installed in LHC. It will stabilise the high intensity beam against coupled bunch transverse instabilities in a frequency range from 3 kHz to 20 MHz and at the same time damp injection oscillations originating from steering errors and injection kicker ripple. The LHC Damper can also be used as means of exciting transverse oscillations for the purposes of abort gap cleaning and tune measurement. The LHC Damper includes 4 feedback systems on 2 circulating beams (in other words one feedback system per beam and plane). Every feedback system consists of 4 electrostatic kickers, 4 push-pull wide band power amplifiers, 8 preamplifiers, two digital processing units and 2 beam position monitors with low-level electronics. The power and low-level subsystem layout is described along with first results from the commissioning of 16 power amplifiers and 16 electrostatic kickers located in the LHC tunnel. The achieved performance is compared with earlier predictions and requirements for injection damping and instability control. Requirements and first measurements of the performance of the power and low-level subsystems are summarized

Highly Sensitive Determination of Hydrogen Peroxide and Glucose by Fluorescence Correlation Spectroscopy

BACKGROUND: Because H(2)O(2) is generated by various oxidase-catalyzed reactions, a highly sensitive determination method of H(2)O(2) is applicable to measurements of low levels of various oxidases and their substrates such as glucose, lactate, glutamate, urate, xanthine, choline, cholesterol and NADPH. We propose herein a new, highly sensitive method for the measurement of H(2)O(2) and glucose using fluorescence correlation spectroscopy (FCS). METHODOLOGY/PRINCIPAL FINDINGS: FCS has the advantage of allowing us to determine the number of fluorescent molecules. FCS measures the fluctuations in fluorescence intensity caused by fluorescent probe movement in a small light cavity with a defined volume generated by confocal illumination. We thus developed a highly sensitive determination system of H(2)O(2) by FCS, where horseradish peroxidase (HRP) catalyzes the formation of a covalent bond between fluorescent molecules and proteins in the presence of H(2)O(2). Our developed system gave a linear calibration curve for H(2)O(2) in the range of 28 to 300 nM with the detection limit of 8 nM. In addition, by coupling with glucose oxidase (GOD)-catalyzed reaction, the method allows to measure glucose in the range of 80 nM to 1.5 µM with detection limit of 24 nM. The method was applicable to the assay of glucose in blood plasma. The mean concentration of glucose in normal human blood plasma was determined to be 4.9 mM. CONCLUSIONS/SIGNIFICANCE: In comparison with commercial available methods, the detection limit and the minimum value of determination for glucose are at least 2 orders of magnitude more sensitive in our system. Such a highly sensitive method leads the fact that only a very small amount of plasma (20 nL) is needed for the determination of glucose concentration in blood plasma

Sarcosine oxidase composite screen-printed electrode for sarcosine determination in biological samples

As the prostate cancer (PCa) progresses, sarcosine levels increase both in tumor cells and urine samples, suggesting that this metabolite measurements can help in the creation of non-invasive diagnostic methods for this disease. In this work, a biosensor device was developed for the quantification of sarcosine via electrochemical detection of H2O2 (at 0.6 V) generated from the catalyzed oxidation of sarcosine. The detection was carried out after the modification of carbon screen printed electrodes (SPEs) by immobilization of sarcosine oxidase (SOX) on the electrode surface. The strategies used herein included the activation of the carbon films by an electrochemical step and the formation of an NHS/EDAC layer to bond the enzyme to the electrode, the use of metallic or semiconductor nanoparticles layer previously or during the enzyme immobilization. In order to improve the sensor stability and selectivity a polymeric layer with extra enzyme content was further added. The proposed methodology for the detection of sarcosine allowed obtaining a limit of detection (LOD) of 16 nM, using a linear concentration range between 10 and 100 nM. The biosensor was successfully applied to the analysis of sarcosine in urine samples

Fostering support for non-democratic rule? Controlled political liberalization and popular support for non-democratic regimes

When the Cold War ended, many non-democratic regimes across the globe embarked on a course of controlled political liberalization, hoping to stabilize their autocratic rule by mitigating popular demands for democratization and increasing regime legitimacy. But does this strategy actually work? This article uses multi-level analyses to examine how the degree of political liberalization affects regime support in non-democratic political systems and to ascertain which mechanisms underlie this effect. Drawing on aggregate measures of political liberalization and comparative survey data from four regional survey projects and 31 non-democracies, the study's results indicate that the degree of liberalization has no decisively positive effect on regime support, suggesting controlled political liberalization might not be an effective legitimizing strategy after all.Nach Ende des Kalten Krieges haben viele nicht-demokratische Regime weltweit einen Kurs der begrenzten politischen Öffnung eingeschlagen, um öffentliche Forderungen nach Demokratisierung zu entschärfen und auf diese Weise die Legitimität ihrer autokratischen Herrschaft zu erhöhen. Doch ist diese Strategie tatsächlich effektiv? Der Beitrag verwendet Mehrebenenanalysen, um zu untersuchen wie der Grad an politischer Öffnung die Regimerunterstützung in nicht-demokratischen politischen Systemen beeinflusst. Auf Basis von Aggregatmaßen zur politischen Öffnung und Individualdaten aus vier regionalen Umfrageprojekten und 31 Autokratien kann kein klarer positiver Effekt des Grads der politischen Öffnung auf die Regimeunterstützung nachgewiesen werden, was eine begrenzte politische Öffnung als wenig effektive Legitimationsstrategie erscheinen lässt

Nafion® as advanced immobilisation substrate for the voltammetric analysis of electroactive microparticles: the case of some artistic colouring agents

Voltammetry of microparticles is applied to characterise and to identify solid analytes of interest in the field of cultural heritage. Nafion® is used for the immobilisation of solid microparticles onto the surface of a glassy carbon electrode by exploiting the deposition onto the electrode surface of a micro-volume of a suspension of the microsample in polymeric solution. Cyclic voltammetry and square wave voltammetry are applied to characterise and to identify the microparticles immobilised in the Nafion® coating. The analyte studied in this work is Prussian Blue as a typical inorganic pigment, with a relatively simple electrochemical behaviour. The proposed method is applied to a sample of Venetian marmorino plaster. The performance of Nafion® for this analysis is compared with that of the polymer Paraloid B72