635 research outputs found
Mixing Time Scales in a Supernova-Driven Interstellar Medium
We study the mixing of chemical species in the interstellar medium (ISM).
Recent observations suggest that the distribution of species such as deuterium
in the ISM may be far from homogeneous. This raises the question of how long it
takes for inhomogeneities to be erased in the ISM, and how this depends on the
length scale of the inhomogeneities. We added a tracer field to the
three-dimensional, supernova-driven ISM model of Avillez (2000) to study mixing
and dispersal in kiloparsec-scale simulations of the ISM with different
supernova (SN) rates and different inhomogeneity length scales. We find several
surprising results. Classical mixing length theory fails to predict the very
weak dependence of mixing time on length scale that we find on scales of
25--500 pc. Derived diffusion coefficients increase exponentially with time,
rather than remaining constant. The variance of composition declines
exponentially, with a time constant of tens of Myr, so that large differences
fade faster than small ones. The time constant depends on the inverse square
root of the supernova rate. One major reason for these results is that even
with numerical diffusion exceeding physical values, gas does not mix quickly
between hot and cold regions.Comment: 23 pages, 14 figures that include 7 simulation images and 19 plots,
accepted for publication at Ap
Magnetic Flux Expulsion in the Powerful Superbubble Explosions and the Alpha-Omega Dynamo
The possibility of the magnetic flux expulsion from the Galaxy in the
superbubble (SB) explosions, important for the Alpha-Omega dynamo, is
considered. Special emphasis is put on the investigation of the downsliding of
the matter from the top of the shell formed by the SB explosion which is able
to influence the kinematics of the shell. It is shown that either Galactic
gravity or the development of the Rayleigh-Taylor instabilities in the shell
limit the SB expansion, thus, making impossible magnetic flux expulsion. The
effect of the cosmic rays in the shell on the sliding is considered and it is
shown that it is negligible compared to Galactic gravity. Thus, the question of
possible mechanism of flux expulsion in the Alpha-Omega dynamo remains open.Comment: MNRAS, in press, 11 pages, 9 figure
GABA(A )receptor Îł2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines
BACKGROUND: Gamma-aminobutyric acid type A receptors (GABA(A)-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics. The significance of specific GABA(A)-Rs subunits with respect to behavior and in vivo drug responses is incompletely understood. The Îł2 subunit is highly expressed throughout the brain. Global Îł2 knockout mice are insensitive to the hypnotic effects of diazepam and die perinatally. Heterozygous Îł2 global knockout mice are viable and have increased anxiety-like behaviors. To further investigate the role of the Îł2 subunit in behavior and whole animal drug action, we used gene targeting to create a novel mouse line with attenuated Îł2 expression, i.e., Îł2 knockdown mice. RESULTS: Knockdown mice were created by inserting a neomycin resistance cassette into intron 8 of the Îł2 gene. Knockdown mice, on average, showed a 65% reduction of Îł2 subunit mRNA compared to controls; however Îł2 gene expression was highly variable in these mice, ranging from 10â95% of normal. Immunohistochemical studies demonstrated that Îł2 protein levels were also variably reduced. Pharmacological studies using autoradiography on frozen brain sections demonstrated that binding of the benzodiazepine site ligand Ro15-4513 was decreased in mutant mice compared to controls. Behaviorally, knockdown mice displayed enhanced anxiety-like behaviors on the elevated plus maze and forced novelty exploration tests. Surprisingly, mutant mice had an unaltered response to hypnotic doses of the benzodiazepine site ligands diazepam, midazolam and zolpidem as well as ethanol and pentobarbital. Lastly, we demonstrated that the Îł2 knockdown mouse line can be used to create Îł2 global knockout mice by crossing to a general deleter cre-expressing mouse line. CONCLUSION: We conclude that: 1) insertion of a neomycin resistance gene into intron 8 of the Îł2 gene variably reduced the amount of Îł2, and that 2) attenuated expression of Îł2 increased anxiety-like behaviors but did not lead to differences in the hypnotic response to benzodiazepine site ligands. This suggests that reduced synaptic inhibition can lead to a phenotype of increased anxiety-like behavior. In contrast, normal drug effects can be maintained despite a dramatic reduction in GABA(A)-R targets
Supersonic turbulence and structure of interstellar molecular clouds
The interstellar medium (ISM) provides a unique laboratory for highly
supersonic, driven hydrodynamics turbulence. We present a theory of such
turbulence, confirm it by numerical simulations, and use the results to explain
observational properties of interstellar molecular clouds, the regions where
stars are born.Comment: 5 pages, 3 figures include
Recommended from our members
Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
IMPORTANCE: Evidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus far, these putative neuroprotective properties have not been reported in human studies. OBJECTIVE: To determine the effect of inhaled xenon on ischemic white matter damage assessed with magnetic resonance imaging (MRI). DESIGN, SETTING, AND PARTICIPANTS: A randomized single-blind phase 2 clinical drug trial conducted between August 2009 and March 2015 at 2 multipurpose intensive care units in Finland. One hundred ten comatose patients (aged 24-76 years) who had experienced out-of-hospital cardiac arrest were randomized. INTERVENTIONS: Patients were randomly assigned to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours (nâ=â55 in the xenon group) or hypothermia treatment alone (nâ=â55 in the control group). MAIN OUTCOMES AND MEASURES: The primary end point was cerebral white matter damage as evaluated by fractional anisotropy from diffusion tensor MRI scheduled to be performed between 36 and 52 hours after cardiac arrest. Secondary end points included neurological outcome assessed using the modified Rankin Scale (score 0 [no symptoms] through 6 [death]) and mortality at 6 months. RESULTS: Among the 110 randomized patients (mean age, 61.5 years; 80 men [72.7%]), all completed the study. There were MRI data from 97 patients (88.2%) a median of 53 hours (interquartile range [IQR], 47-64 hours) after cardiac arrest. The mean global fractional anisotropy values were 0.433 (SD, 0.028) in the xenon group and 0.419 (SD, 0.033) in the control group. The age-, sex-, and site-adjusted mean global fractional anisotropy value was 3.8% higher (95% CI, 1.1%-6.4%) in the xenon group (adjusted mean difference, 0.016 [95% CI, 0.005-0.027], Pâ=â.006). At 6 months, 75 patients (68.2%) were alive. Secondary end points at 6 months did not reveal statistically significant differences between the groups. In ordinal analysis of the modified Rankin Scale, the median (IQR) value was 1 (1-6) in the xenon group and 1 (0-6) in the control group (median difference, 0 [95% CI, 0-0]; Pâ=â.68). The 6-month mortality rate was 27.3% (15/55) in the xenon group and 34.5% (19/55) in the control group (adjusted hazard ratio, 0.49 [95% CI, 0.23-1.01]; Pâ=â.053). CONCLUSIONS AND RELEVANCE: Among comatose survivors of out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia compared with hypothermia alone resulted in less white matter damage as measured by fractional anisotropy of diffusion tensor MRI. However, there was no statistically significant difference in neurological outcomes or mortality at 6 months. These preliminary findings require further evaluation in an adequately powered clinical trial designed to assess clinical outcomes associated with inhaled xenon among survivors of out-of-hospital cardiac arrest. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00879892
Interstellar Turbulence II: Implications and Effects
Interstellar turbulence has implications for the dispersal and mixing of the
elements, cloud chemistry, cosmic ray scattering, and radio wave propagation
through the ionized medium. This review discusses the observations and theory
of these effects. Metallicity fluctuations are summarized, and the theory of
turbulent transport of passive tracers is reviewed. Modeling methods, turbulent
concentration of dust grains, and the turbulent washout of radial abundance
gradients are discussed. Interstellar chemistry is affected by turbulent
transport of various species between environments with different physical
properties and by turbulent heating in shocks, vortical dissipation regions,
and local regions of enhanced ambipolar diffusion. Cosmic rays are scattered
and accelerated in turbulent magnetic waves and shocks, and they generate
turbulence on the scale of their gyroradii. Radio wave scintillation is an
important diagnostic for small scale turbulence in the ionized medium, giving
information about the power spectrum and amplitude of fluctuations. The theory
of diffraction and refraction is reviewed, as are the main observations and
scintillation regions.Comment: 46 pages, 2 figures, submitted to Annual Reviews of Astronomy and
Astrophysic
Importance of GluA1 Subunit-Containing AMPA Glutamate Receptors for Morphine State-Dependency
Peer reviewe
Simulations of galactic dynamos
We review our current understanding of galactic dynamo theory, paying
particular attention to numerical simulations both of the mean-field equations
and the original three-dimensional equations relevant to describing the
magnetic field evolution for a turbulent flow. We emphasize the theoretical
difficulties in explaining non-axisymmetric magnetic fields in galaxies and
discuss the observational basis for such results in terms of rotation measure
analysis. Next, we discuss nonlinear theory, the role of magnetic helicity
conservation and magnetic helicity fluxes. This leads to the possibility that
galactic magnetic fields may be bi-helical, with opposite signs of helicity and
large and small length scales. We discuss their observational signatures and
close by discussing the possibilities of explaining the origin of primordial
magnetic fields.Comment: 28 pages, 15 figure, to appear in Lecture Notes in Physics "Magnetic
fields in diffuse media", Eds. E. de Gouveia Dal Pino and A. Lazaria
Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor types
Astrophysical turbulence modeling
The role of turbulence in various astrophysical settings is reviewed. Among
the differences to laboratory and atmospheric turbulence we highlight the
ubiquitous presence of magnetic fields that are generally produced and
maintained by dynamo action. The extreme temperature and density contrasts and
stratifications are emphasized in connection with turbulence in the
interstellar medium and in stars with outer convection zones, respectively. In
many cases turbulence plays an essential role in facilitating enhanced
transport of mass, momentum, energy, and magnetic fields in terms of the
corresponding coarse-grained mean fields. Those transport properties are
usually strongly modified by anisotropies and often completely new effects
emerge in such a description that have no correspondence in terms of the
original (non coarse-grained) fields.Comment: 88 pages, 26 figures, published in Reports on Progress in Physic
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