4 research outputs found
Trends in der Epidemiologie, Therapie und den Behandlungsergebnissen von Kopf-Hals-Tumoren: Eine populationsbezogene Langzeitanalyse der Thüringer Krebsregister von 1996 bis 2011
Trends in der Epidemiologie, Therapie und den Behandlungsergebnissen von Kopf-Hals-Tumoren: Eine populationsbezogene Langzeitanalyse der Thüringer Krebsregister von 1996 bis 2011
Nature
regulates complex structures in space and time via feedback
loops, kinetically controlled transformations, and under energy dissipation
to allow non-equilibrium processes. Although man-made static self-assemblies
realize excellent control over hierarchical structures via molecular
programming, managing their temporal destiny by self-regulation is
a largely unsolved challenge. Herein, we introduce a generic concept
to control the time domain by programming the lifetimes of switchable
self-assemblies in closed systems. We conceive dormant deactivators
that, in combination with fast promoters, enable a unique kinetic
balance to establish an autonomously self-regulating, transient pH-state,
whose duration can be programmed over orders of magnitudefrom
minutes to days. Coupling this non-equilibrium state to pH-switchable
self-assemblies allows predicting their assembly/disassembly fate
in time, similar to a precise self-destruction mechanism. We demonstrate
a platform approach by programming self-assembly lifetimes of block
copolymers, nanoparticles, and peptides, enabling dynamic materials
with a self-regulation functionality