Trends in der Epidemiologie, Therapie und den Behandlungsergebnissen von Kopf-Hals-Tumoren: Eine populationsbezogene Langzeitanalyse der Thüringer Krebsregister von 1996 bis 2011
German Medical Science GMS Publishing House; Düsseldorf
Doi
Abstract
Nature
regulates complex structures in space and time via feedback
loops, kinetically controlled transformations, and under energy dissipation
to allow non-equilibrium processes. Although man-made static self-assemblies
realize excellent control over hierarchical structures via molecular
programming, managing their temporal destiny by self-regulation is
a largely unsolved challenge. Herein, we introduce a generic concept
to control the time domain by programming the lifetimes of switchable
self-assemblies in closed systems. We conceive dormant deactivators
that, in combination with fast promoters, enable a unique kinetic
balance to establish an autonomously self-regulating, transient pH-state,
whose duration can be programmed over orders of magnitudefrom
minutes to days. Coupling this non-equilibrium state to pH-switchable
self-assemblies allows predicting their assembly/disassembly fate
in time, similar to a precise self-destruction mechanism. We demonstrate
a platform approach by programming self-assembly lifetimes of block
copolymers, nanoparticles, and peptides, enabling dynamic materials
with a self-regulation functionality