Can mean platelet volume be used as a biomarker for asthma?

Introduction : Platelets play important roles in airway inflammation and are activated in inflammatory lung diseases, including asthma. Aim :We evaluated the mean platelet volume (MPV), used as a marker of platelet activation, in asthmatic patients during asymptomatic periods and exacerbations compared to healthy controls to determine whether MPV can be used as an indicator of inflammation. Material and methods :Our patient group consisted of95 children with exacerbation of asthma who were admitted to our allergy clinic. The control group consisted of 100 healthy children matched for age, gender, and ethnicity. Mean platelet volume values of the patient group obtained during exacerbation of asthma were compared to those of the same group during the asymptomatic period and with the control group. We investigated factors that can affect the MPV values of asthma patients, including infection, atopy, immunotherapy treatment, and severity of asthma exacerbation. Results :The patient group consisted of 50 (52.6%) boys and 45 (47.4%) girls with a mean age of 125 ±38 months old. Mean MPV values in the exacerbation period, the healthy period, and in the control group were 8.1 ±0.8 fl, 8.1 ±1.06 fl, and 8.2 ±0.9 fl, respectively; there were no significant differences between groups (p > 0.05). The severity of asthma, severity of asthma exacerbation, immunotherapy, coinfection, eosinophil count, and IgE level also had no effect on MPV (p > 0.05). Conclusions : Although platelets play a rolein the pathophysiology of asthma, MPV measurement is insufficient to detect inflammation through platelet

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised

A case of immune-mediated type 1 diabetes mellitus due to congenital rubella infection

Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and severe fetal injury. It has been shown that type 1 diabetes mellitus develops in 12%-20% of patients with congenital rubella infection, and disorders in the oral glucose tolerance test is observed in 40% of patients. No biochemical or serological markers exist which could indicate that type 1 diabetes was caused by a congenital rubella infection. We report a 13-year-old male patient who was admitted to our hospital with complaints of new-onset polyuria, polydipsia, urination, and weight loss. In addition, he was found to have neurosensory hearing loss, patent ductus arteriosus, and microcephaly. Immune-mediated type 1 diabetes mellitus was considered due to the fact that the autoantibodies of diabetes mellitus were positive

Presenting with Isolated Hepatitis Caused by Congenital Rubella Infection Due to Maternal Rubella Vaccination

Congenital rubella syndrome is a transplacental infection that may cause serious devastating damage in the fetus, including intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and hepatitis. Rubella vaccine is administered for preventing congenital rubella syndrome. It is suggested that patients must be screened for pregnancy before vaccination and should be informed regarding contraception for 3 months after vaccination. Herein, we presented a 1-month-old boy to whom rubella vaccine was administered. After performing multiple diagnostic studies to exclude other liver disorders, the patient, who had high liver enzymes, was diagnosed with congenital rubella infection by his mother's history and positive anti-rubella IgM. His liver enzymes returned to normal at 2 months of age of the follow-up period. Negative anti-rubella IgM was revealed at 6 months of age. As a result, when rubella vaccine is administered in pregnancy, high liver enzymes might occur without other congenital rubella syndrome signs in newborns. Infants who are borne by pregnant women with rubella vaccination should be monitored

Presenting with Isolated Hepatitis Caused by Congenital Rubella Infection Due to Maternal Rubella Vaccination

Congenital rubella syndrome is a transplacental infection that may cause serious devastating damage in the fetus, including intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and hepatitis. Rubella vaccine is administered for preventing congenital rubella syndrome. It is suggested that patients must be screened for pregnancy before vaccination and should be informed regarding contraception for 3 months after vaccination. Herein, we presented a 1-month-old boy to whom rubella vaccine was administered. After performing multiple diagnostic studies to exclude other liver disorders, the patient, who had high liver enzymes, was diagnosed with congenital rubella infection by his mother's history and positive anti-rubella IgM. His liver enzymes returned to normal at 2 months of age of the follow-up period. Negative anti-rubella IgM was revealed at 6 months of age. As a result, when rubella vaccine is administered in pregnancy, high liver enzymes might occur without other congenital rubella syndrome signs in newborns. Infants who are borne by pregnant women with rubella vaccination should be monitored

Comparison of acellular pertussis-tetanus-diphtheria vaccines and whole-cell pertussis-tetanus- diphtheria vaccines in infancy

Background: In clinical trials, diphtheria, tetanus and acellular pertussis vaccines have been shown to be less reactogenic than whole- cell combination vaccines

Attempted suicide with levothyroxine in an adolescent girl

Attempted suicide with levothyroxine is very rare and has been described only in a few case reports. Although acute accidental or intentional overdoses of thyroid hormones can lead to marked elevations in serum T 4 levels, many children who take as much as 5-10 mg of levothyroxine as a single dose have few or no symptoms of thyrotoxicosis. We report an adolescent girl who attempted suicide by ingesting levothyroxine. She responded well to beta-adrenergic blockade

Attempted suicide with levothyroxine in an adolescent girl

Attempted suicide with levothyroxine is very rare and has been described only in a few case reports. Although acute accidental or intentional overdoses of thyroid hormones can lead to marked elevations in serum T 4 levels, many children who take as much as 5-10 mg of levothyroxine as a single dose have few or no symptoms of thyrotoxicosis. We report an adolescent girl who attempted suicide by ingesting levothyroxine. She responded well to beta-adrenergic blockade

Allopurinol Ameliorates Non-Alcoholic Fatty Liver Disease in Rats

WOS: 00044520410210