15 research outputs found
A facility to Search for Hidden Particles (SHiP) at the CERN SPS
A new general purpose fixed target facility is proposed at the CERN SPS
accelerator which is aimed at exploring the domain of hidden particles and make
measurements with tau neutrinos. Hidden particles are predicted by a large
number of models beyond the Standard Model. The high intensity of the SPS
400~GeV beam allows probing a wide variety of models containing light
long-lived exotic particles with masses below (10)~GeV/c,
including very weakly interacting low-energy SUSY states. The experimental
programme of the proposed facility is capable of being extended in the future,
e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa
A facility to Search for Hidden Particles (SHiP) at the CERN SPS
A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below (10)~GeV/c, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation
Genetic landscape in Russian patients with familial left ventricular noncompaction
BackgroundLeft ventricular noncompaction (LVNC) cardiomyopathy is a disorder that can be complicated by heart failure, arrhythmias, thromboembolism, and sudden cardiac death. The aim of this study is to clarify the genetic landscape of LVNC in a large cohort of well-phenotyped Russian patients with LVNC, including 48 families (n=214).MethodsAll index patients underwent clinical examination and genetic analysis, as well as family members who agreed to participate in the clinical study and/or in the genetic testing. The genetic testing included next generation sequencing and genetic classification according to ACMG guidelines.ResultsA total of 55 alleles of 54 pathogenic and likely pathogenic variants in 24 genes were identified, with the largest number in the MYH7 and TTN genes. A significant proportion of variants −8 of 54 (14.8%) −have not been described earlier in other populations and may be specific to LVNC patients in Russia. In LVNC patients, the presence of each subsequent variant is associated with increased odds of having more severe LVNC subtypes than isolated LVNC with preserved ejection fraction. The corresponding odds ratio is 2.77 (1.37 −7.37; p <0.001) per variant after adjustment for sex, age, and family.ConclusionOverall, the genetic analysis of LVNC patients, accompanied by cardiomyopathy-related family history analysis, resulted in a high diagnostic yield of 89.6%. These results suggest that genetic screening should be applied to the diagnosis and prognosis of LVNC patients
A facility to Search for Hidden Particles (SHiP) at the CERN SPS
A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below (10)~GeV/c, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation
АНАЛІЗ МОДЕЛЕЙ РОЗРАХУНКУ ТРУБ СИСТЕМИ «КОНСТРУКЦІЯ-ҐРУНТ»
Recently in the European countries the designs of flexible pipes and pipe bridges, the bearing capacity of which is provided by passive resistance of soil, have found more applications. The paper presents an analysis of existing models for calculating flexible pipes working as a system «construction-soil». The numerical example for calculating such construction design using software package SCAD is given.В последнее время в странах Европы стали чаще применятся конструкции гибких труб и труб-мостов, несущая способность которых обеспечивается пассивным сопротивлением грунта. В статье представлен анализ существующих моделей расчета гибких труб, работающих как система «конструкция-грунт», приведен пример расчета такой конструкции в программном комплексе SCAD.Останнім часом в країнах Європи набули поширення конструкції гнучких труб та труб-мостів, несна здатність яких забезпечується завдяки пасивному опору ґрунту. В статті представлено аналіз існуючих моделей розрахунку гнучких труб, що працюють як система «конструкція-ґрунт», та наведено приклад розрахунку такої конструкції в програмному комплексі SCAD
Quantitative Assessment of Myocardial Ischemia in Multi-Vessel Coronary Artery Disease by Multimodal Stress Echocardiography with Semi-Supine Bicycle Ergometry
Stress echocardiography is a modern widely used method of noninvasive diagnosis of coronary heart disease and stratification of the risk of cardiovascular complications. In addition, exercise echocardiography is an important tool to clarify the localization of ischemia and establish a symptomassociated artery for management of patient with known coronary angiography data. This is especially important in multivessel lesions, the presence of an occluded artery or borderline stenosis. Currently, various stress agents are used for stress echocardiography in clinical practice: pharmacological drugs (dobutamine or adenosine), transesophageal or endocardial pacing, treadmill, semi-supine bicycle. To detect signs of ischemia usually used only visual estimation of local contractility in the two-dimensional gray-scale mode. Modern modes of myocardial imaging, such as speckletracking echocardiography or three-dimensional visualization, are practically not used. In the presented clinical case, the possibility of combining standard and modern imaging modes to clarify the localization and quantification of ischemia in multivessel coronary lesions, including chronic artery occlusion, is shown. As a stress agent, a semi-supine bicycle was chosen, the use of which allowed to obtain a qualitative image of the left ventricular myocardium at rest and at peak load, suitable for assessing deformation and threedimensional visualization. Evaluation of left ventricular myocardial deformation by speckle-tracking echocardiography was more accurate than standard diagnosis in detecting signs of ischemia in a patient with multivessel lesions. Three-dimensional imaging was inferior in sensitivity to speckletracking stress echocardiography and, at present, seems to have more research value
ANALYSIS OF FUNNELS EVALUATION MODEL BY THE “CONSTRUCTION-SOIL” SYSTEM
Recently in the European countries the designs of flexible pipes and pipe bridges, the bearing capacity of which is provided by passive resistance of soil, have found more applications. The paper presents an analysis of existing models for calculating flexible pipes working as a system «construction-soil». The numerical example for calculating such construction design using software package SCAD is given
RadioPhysical methods of determination of component composition of fine-dyspersated mixtures. Part 2
Приведены результаты анализа радиофизических методов и экспериментальные данные по использованию аппаратуры сантиметрового и миллиметрового диапазонов длин волн для определения процентного содержания компонент мелкодисперсных смесей на различных стадиях технологического процесса.Наведені результати аналітичного дослідження радіофізичних методів визначення компонентного складу дрібнодисперсних сумішей на різних стадіях технологічного процесу.Brought results of analytical study of radiophysical methods of determination of component composition of fine-dyspersated mixtures on different stages of technological process
The non-compact left ventricle cardiomyopathy: clinical features and diagnostic capabilities
The non-compact left ventricular cardiomyopathy (NCLVC) refers to the non-classified cardiomyopathies. Its cause is not completely clear. NCLVC is characterized by an increased trabecular with the formation of deep intertrabecular crypts. It can exist either in isolated form or in combination with other congenital diseases. The clinical features of NCLVC are different: asymptomatic forms are identified as well as forms with the progressive course of the disease, with heart failure, angina, thromboembolic complications, and ventricular arrhythmias. In some cases, the disease starts with the sudden cardiac death. The sudden decompensation of NCLVC also could arise due to the development of acute myocarditis</p
New Variant of <i>MYH7</i> Gene Nucleotide Sequence in Familial Non-Compaction Cardiomyopathy with Benign Course
Left ventricular non-compaction (LVNC) is a genetically determined cardiomyopathy characterized by different variants of the clinical course. LVNC family cases allow to study in more details the role of genetic factors in cardiomyopathy pathogenesis and prognosis, as well as to determine clinical course features.Aim. To demonstrate a case of LVNC familial form with a stable benign course and to assess the possible relationship of the detected mutation with the disease prognosis.Material and methods. A family with LVNC was included in the study. The patient with LVNC and his 1st and 2nd degree of kinship relatives underwent clinical and instrumental examination and exome sequencing. LVNC was diagnosed in proband and proband's father. LVNC diagnosis was established basing on echo and magnetic resonance imaging (MRI) criteria.Results. This article presents the results of a comprehensive clinical and instrumental examination of a family with LVNC with a new variant in the MYH7 gene, the absence of intramyocardial fibrosis according to MRI of the heart and a favorable disease course, both in proband's father and proband himself. A comparative analysis of the data obtained with the results of recent large-scale studies and meta-analyses devoted to the study of prognostic factors in patients with LVNC, with identified variants in the MYH7 gene.Conclusions. The variant of p.His1338Pro identified in the MYH7 gene may be associated with the development of LVNC with a benign course