Social behavior modeling based on Incremental Discrete Hidden Markov Models

12 pagesInternational audienceModeling multimodal face-to-face interaction is a crucial step in the process of building social robots or users-aware Embodied Conversational Agents (ECA). In this context, we present a novel approach for human behavior analysis and generation based on what we called "Incremental Discrete Hidden Markov Model" (IDHMM). Joint multimodal activities of interlocutors are first modeled by a set of DHMMs that are specific to supposed joint cognitive states of the interlocutors. Respecting a task-specific syntax, the IDHMM is then built from these DHMMs and split into i) a recognition model that will determine the most likely sequence of cognitive states given the multimodal activity of the in- terlocutor, and ii) a generative model that will compute the most likely activity of the speaker given this estimated sequence of cognitive states. Short-Term Viterbi (STV) decoding is used to incrementally recognize and generate behav- ior. The proposed model is applied to parallel speech and gaze data of interact- ing dyads

Incidence trends of lung and gastroenteropancreatic neuroendocrine neoplasms in Switzerland.

The incidence of neuroendocrine neoplasms (NENs) seems to increase worldwide. Long-term, population-based series that consider tumor differentiation are, however, sparse. We assessed the incidence trend of lung and gastroenteropancreatic (GEP) NENs according to the latest International Agency for Research on Cancer/World Health Organization classification over a 41-year time period in two Swiss regions. All cases of lung and GEP NENs recorded in the Vaud and Neuchâtel Cancer Registries from 1976 to 2016 were included. NENs were stratified into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Changes in annual age-standardized incidence rates were calculated for lung and GEP NETs and NECs by sex. Of 4,141 patients diagnosed with NENs, 65% were men. The incidence of lung NETs among men and women increased by 3.9%/year (95% CI: -5.3, 14.1%) and 4.9%/year (0.1, 9.9%), respectively, between 1976 and 2016. The incidence of lung NECs decreased by 2.6%/year (-3.1,-1.8%) in men from 1985 to 2016 whereas it increased in women between 1976 and 1998 by 6%/year (4.2, 7.9%). For GEP NETs, a steady annual increase in incidence occurred between 1976 and 2016 with a magnitude of 1.7% (0.7, 2.7%) in men and 1.3% (0.5, 2.1%) in women. No significant trend in incidence of GEP NECs was found for both sexes. The incidence trends of lung NECs in men and women parallel changes in smoking prevalence in the population. Causes of the increase in incidence of GEP NETs are likely multifactorial. Our study supports the importance of evaluating the epidemiology of NENs by tumor differentiation

EIS/Hinode observations of Doppler flow seen through the 40 arcsec wide slit

The Extreme ultraviolet Imaging Spectrometer (EIS) on board Hinode is the first solar telescope to obtain wide slit spectral images that can be used for detecting Doppler flows in transition region and coronal lines on the Sun and to relate them to their surrounding small scale dynamics. We select EIS lines covering the temperature range 6x10^4 K to 2x10^6 K that give spectrally pure images of the Sun with the 40 arcsec slit. In these images Doppler shifts are seen as horizontal brightenings. Inside the image it is difficult to distinguish shifts from horizontal structures but emission beyond the image edge can be unambiguously identified as a line shift in several lines separated from others on their blue or red side by more than the width of the spectrometer slit (40 pixels). In the blue wing of He II, we find a large number of events with properties (size and lifetime) similar to the well-studied explosive events seen in the ultraviolet spectral range. Comparison with X-Ray Telescope (XRT) images shows many Doppler shift events at the footpoints of small X-ray loops. The most spectacular event observed showed a strong blue shift in transition region and lower corona lines from a small X-ray spot that lasted less than 7 min. The emission appears to be near a cool coronal loop connecting an X-ray bright point to an adjacent region of quiet Sun. The width of the emission implies a line-of-sight velocity of 220 km/s. In addition, we show an example of an Fe XV shift with a velocity about 120 km/s, coming from what looks like a narrow loop leg connecting a small X-ray brightening to a larger region of X-ray emission.Comment: 12 pages, 8 figures, to be published in Solar Physic

Dark Matter attempts for CoGeNT and DAMA

Recently, the CoGeNT collaboration presented a positive signal for an annual modulation in their data set. In light of the long standing annual modulation signal in DAMA/LIBRA, we analyze the compatibility of both of these signal within the hypothesis of dark matter (DM) scattering on nuclei, taking into account existing experimental constraints. We consider the cases of elastic and inelastic scattering with either spin-dependent or spin-independent coupling to nucleons. We allow for isospin violating interactions as well as for light mediators. We find that there is some tension between the size of the modulation signal and the time-integrated event excess in CoGeNT, making it difficult to explain both simultaneously. Moreover, within the wide range of DM interaction models considered, we do not find a simultaneous explanation of CoGeNT and DAMA/LIBRA compatible with constraints from other experiments. However, in certain cases part of the data can be made consistent. For example, the modulation signal from CoGeNT becomes consistent with the total rate and with limits from other DM searches at 90% CL (but not with the DAMA/LIBRA signal) if DM scattering is inelastic spin-independent with just the right couplings to protons and neutrons to reduce the scattering rate on xenon. Conversely the DAMA/LIBRA signal (but not CoGeNT) can be explained by spin-dependent inelastic DM scattering.Comment: 20 pages, 9 figure

Hadronic Charmed Meson Decays Involving Tensor Mesons

Charmed meson decays into a pseudoscalar meson P and a tensor meson T are studied. The charm to tensor meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise (ISGW) quark model. It is shown that the Cabibbo-allowed decay $D_s^+\to f_2(1270)\pi^+$ is dominated by the W-annihilation contribution and has the largest branching ratio in $D\to TP$ decays. We argue that the Cabibbo-suppressed mode $D^+\to f_2(1270)\pi^+$ should be suppressed by one order of magnitude relative to $D_s^+\to f_2(1270)\pi^+$. When the finite width effect of the tensor resonances is taken into account, the decay rate of $D\to TP$ is generally enhanced by a factor of $2\sim 3$. Except for $D_s^+\to f_2(1270)\pi^+$, the predicted branching ratios of $D\to TP$ decays are in general too small by one to two orders of magnitude compared to experiment. However, it is very unlikely that the $D\to T$ transition form factors can be enhanced by a factor of $3\sim 5$ within the ISGW quark model to account for the discrepancy between theory and experiment. As many of the current data are still preliminary and lack sufficient statistic significance, more accurate measurements are needed to pin down the issue.Comment: 11 page

Hadronic Charmed Meson Decays Involving Axial Vector Mesons

Cabibbo-allowed charmed meson decays into a pseudoscalar meson and an axial-vector meson are studied. The charm to axial-vector meson transition form factors are evaluated in the Isgur-Scora-Grinstein-Wise quark model. The dipole momentum dependence of the $D\to K$ transition form factor and the presence of a sizable long-distance $W$-exchange are the two key ingredients for understanding the data of $D\to \bar Ka_1$. The $K_{1A}-K_{1B}$ mixing angle of the strange axial-vector mesons is found to be $\approx \pm37^\circ$ or $\pm58^\circ$ from $\tau\to K_1\nu_\tau$ decays. The study of $D\to K_1(1270)\pi, K_1(1400)\pi$ decays excludes the positive mixing-angle solutions. It is pointed out that an observation of the decay $D^0\to K_1^-(1400)\pi^+$ at the level of $5\times 10^{-4}$ will rule out $\theta\approx -37^\circ$ and favor the solution $\theta\approx -58^\circ$. Though the decays $D^0\to \bar K_1^0\pi^0$ are color suppressed, they are comparable to and even larger than the color-allowed counterparts: $\bar K_1^0(1270)\pi^0\sim K_1^-(1270)\pi^+$ and $\bar K_1^0(1400)\pi^0> K_1^-(1400)\pi^+$. The finite width effect of the axial-vector resonance is examined. It becomes important for $a_1(1260)$ in particular when its width is near 600 MeV.Comment: 19 page

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells

BACKGROUND: Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology. RESULTS: We demonstrate that conditional knockout of Sox9 in the mouse mammary gland results in impaired postnatal development. In short-term lineage tracing in the postnatal mouse mammary gland using Sox9-CreER driven reporters, Sox9 marked primarily the luminal progenitors and bipotent stem/progenitor cells within the basal mammary epithelial compartment. In contrast, long-term lineage tracing studies demonstrate that Sox9+ precursors gave rise to both luminal and myoepithelial cell lineages. Finally, fate mapping of Sox9 deleted cells demonstrates that Sox9 is essential for luminal, but not myoepithelial, lineage commitment and proliferation. CONCLUSIONS: These studies identify Sox9 as a key regulator of mammary gland development and stem/progenitor maintenance

A Statistical Study on the Morphology of Rays and Dynamics of Blobs in the Wake of Coronal Mass Ejections

In this paper, with a survey through the Large Angle and Spectrometric Coronagraph (LASCO) data from 1996 to 2009, we present 11 events with plasma blobs flowing outwards sequentially along a bright coronal ray in the wake of a coronal mass ejection. The ray is believed to be associated with the current sheet structure that formed as a result of solar eruption, and the blobs are products of magnetic reconnection occurring along the current sheet. The ray morphology and blob dynamics are investigated statistically. It is found that the apparent angular widths of the rays at a fixed time vary in a range of 2.1-6.6 (2.0-4.4) degrees with an average of 3.5 (2.9) degrees at 3 (4) Rs, respectively, and the observed durations of the events vary from 12 h to a few days with an average of 27 h. It is also found, based on the analysis of blob motions, that 58% (26) of the blobs were accelerated, 20% (9) were decelerated, and 22% (10) moved with a nearly-constant speed. Comparing the dynamics of our blobs and those that are observed above the tip of a helmet streamer, we find that the speeds and accelerations of the blobs in these two cases differ significantly. It is suggested that these differences of the blob dynamics stem from the associated magnetic reconnection involving different magnetic field configurations and triggering processes.Comment: 12 pages, 6 figures, accepted by Solar Physic

Improved Constraints on Inelastic Dark Matter

We perform an extensive study of the DAMA annual modulation data in the context of inelastic dark matter. We find that inelastic dark matter with mass m > 15 GeV is excluded at the 95% confidence level by the combination of DAMA spectral information and results from other direct detection experiments. However, at smaller m, inelastic dark matter constitutes a possible solution to the DAMA puzzle.Comment: 22 pages, 7 figures, Reference added, matches published versio

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

Pancreatic ductal adenocarcinoma (PDAC) is associated with metaplastic changes in the pancreas but the transcriptional program underlying these changes is incompletely understood. The zinc finger transcription factor, PRDM3, is lowly expressed in normal pancreatic acini and its expression increases during tumorigenesis. Although PRDM3 promotes proliferation and migration of PDAC cell lines, the role of PRDM3 during tumor initiation from pancreatic acinar cells in vivo is unclear. In this study, we showed that high levels of PRDM3 expression in human pancreas was associated with pancreatitis, and well-differentiated but not poorly differentiated carcinoma. We examined PRDM3 function in pancreatic acinar cells during tumor formation and pancreatitis by inactivating Prdm3 using a conditional allele (Ptf1a(CreER);Prdm3(flox/flox) mice) in the context of oncogenic Kras expression and supraphysiological cerulein injections, respectively. In Prdm3-deficient mice, Kras(G12D)-driven preneoplastic lesions were more abundant and progressed to high-grade precancerous lesions more rapidly. This is consistent with our observations that low levels of PRDM3 in human PDAC was correlated significantly with poorer survival in patient. Moreover, loss of Prdm3 in acinar cells elevated exocrine injury, enhanced immune cell activation and infiltration, and greatly increased acinar-to-ductal cell reprogramming upon cerulein-induced pancreatitis. Whole transcriptome analyses of Prdm3 knockout acini revealed that pathways involved in inflammatory response and Hif-1 signaling were significantly upregulated in Prdm3-depleted acinar cells. Taken together, our results suggest that Prdm3 favors the maintenance of acinar cell homeostasis through modulation of their response to inflammation and oncogenic Kras activation, and thus plays a previously unexpected suppressive role during PDAC initiation