Experimental And Numerical Investigation Of The Heat Transfer Inside A Hollow Piston Rod

The heat transfer in the system piston - piston rod - crosshead of reciprocating compressors can be influenced by a fluid enclosed in an internal cavity. Thus, heat is transferred by the fluid flow inside the hollow parts utilizing the reciprocating motion. Subsequently, the high working frequency of such compressors can lead to an improved cooling of the high temperature compressor parts in comparison with conventional solid material designs.  For the experimental examination of this cooling concept a test rig has been set up at the Technische Universität Dresden which comprises a vertically oscillating hollow rod that is heated at its upper end and cooled at its lower end. Among other factors the heat transfer of this cooling concept is affected by the internal diameter of the piston rod. In order to quantify the influence of the internal diameter on the axial heat transfer three different hollow rods with varying internal diameters where investigated by means of temperature measurements.  The experimental results are presented and the influence of the size of the cavity is discussed. Furthermore, the measured temperatures are used for numerical simulations of the test rig in order to derive the axial heat flux of the fluid inside the cavity. Based on the resulting values the heat transfer capability of the investigated cooling concept can be examined with respect to the internal diameter and the benefit for the cooling of different compressor components can be estimated

El Estado Federal Unitario

El presente trabajo analiza en la primera parte los déficit teóricos en la doctrina alemanadel 1962 relativos a la conformación del Estado Federal. Se fija en la ausencia de teorías generalesy discute las dos elaboraciones más completas, la teoría de los tres elementos y el principio deconfianza federal. En la segunda parte repasa las tendencias unitarias del Estado federal, a travésde la coordinación voluntaria entre los Länder y la intervención de éstos por medio del Bundesrat.En la tercera parte, el autor intenta conceptuar su idea del Estado federal unitario y reflejar lasconsecuencias para el conjunto

Thermodynamic Investigation and Design Concept of a bi-directional Wankel Machine for Compression and Expansion in Natural Gas Storage and Distribution Applications

The distribution and storage of natural gas is based on different pressure levels. The pressure is increased by process gas compressors and currently reduced by throttling valves. The isenthalpic throttling leads to exergy losses. As part of an industry project the TU Dresden and the IME Aachen GmbH developed a bi-directional Wankel machine that may be used for both compression and expansion and thus recover some of the exergy losses. The Wankel machine uses rotary valves for suction and discharge control with fixed opening and closing angles in regards to the displacer rotation. This study shows the detailed design concept of the Wankel machine and the corresponding thermodynamic model, which is based on the compressor calculation software KVA developed at the TU Dresden. The model and its results were used to conduct an in-depth analysis of the machine, including pressures and temperature curves during one displacer rotation, its expected overall efficiencies, occurring exergy losses and its economic potential. The results reveal a considerable energy savings potential for future natural gas storage and distribution application

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood. Here, we utilized available gene expression data sets of selected brain regions of HD patients and controls for systematic interaction network filtering in order to predict disease-relevant, brain region-specific HTT interaction partners. Starting from a large protein-protein interaction (PPI) data set, a step-by-step computational filtering strategy facilitated the generation of a focused PPI network that directly or indirectly connects 13 proteins potentially dysregulated in HD with the disease protein HTT. This network enabled the discovery of the neuron-specific protein CRMP1 that targets aggregation-prone, N-terminal HTT fragments and suppresses their spontaneous self-assembly into proteotoxic structures in various models of HD. Experimental validation indicates that our network filtering procedure provides a simple but powerful strategy to identify disease-relevant proteins that influence misfolding and aggregation of polyQ disease proteins.DFG [SFB740, 740/2-11, SFB618, 618/3-09, SFB/TRR43 A7]; BMBF(NGFN-Plus) [01GS08169-73, 01GS08150, 01GS08108]; HDSA Coalition for the Cure; EU (EuroSpin) [Health-F2-2009-241498, HEALTH-F2-2009-242167]; Helmholtz Association (MSBN, HelMA) [HA-215]; FCT [IF/00881/2013]info:eu-repo/semantics/publishedVersio

The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged).Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editin

The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase

The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory. Athena is a versatile observatory designed to address the Hot and Energetic Universe science theme, as selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), X-IFU aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over a hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR (i.e. in the course of its preliminary definition phase, so-called B1), browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters, such as the instrument efficiency, spectral resolution, energy scale knowledge, count rate capability, non X-ray background and target of opportunity efficiency. Finally, we briefly discuss the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, touch on communication and outreach activities, the consortium organisation and the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. The X-IFU will be provided by an international consortium led by France, The Netherlands and Italy, with ESA member state contributions from Belgium, Czech Republic, Finland, Germany, Poland, Spain, Switzerland, with additional contributions from the United States and Japan.The French contribution to X-IFU is funded by CNES, CNRS and CEA. This work has been also supported by ASI (Italian Space Agency) through the Contract 2019-27-HH.0, and by the ESA (European Space Agency) Core Technology Program (CTP) Contract No. 4000114932/15/NL/BW and the AREMBES - ESA CTP No.4000116655/16/NL/BW. This publication is part of grant RTI2018-096686-B-C21 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. This publication is part of grant RTI2018-096686-B-C21 and PID2020-115325GB-C31 funded by MCIN/AEI/10.13039/501100011033

El Estado federal unitario

El presente trabajo analiza en la primera parte los déficit teóricos en la doctrina alemana del 1962 relativos a la conformación del Estado Federal. Se fija en la ausencia de teorías generales y discute las dos elaboraciones más completas, la teoría de los tres elementos y el principio de confianza federal. En la segunda parte repasa las tendencias unitarias del Estado federal, a través de la coordinación voluntaria entre los Länder y la intervención de éstos por medio del Bundesrat. En la tercera parte, el autor intenta conceptuar su idea del Estado federal unitario y reflejar las consecuencias para el conjunto