Research of the immunization coverage and infectious morbidity rates in Ukraine and in the WHO European region

The article presents results of a comparative analysis of levels of immunization coverage against infectious diseases that can be prevented by routine vaccination, in Ukraine and in other countries in the European Region of WHO. It was found that starting from 2010 immunization coverage decreased in Ukraine. None of the infectious nosology achieved the WHO recommended level of 95% immunization coverage in 2013.It was analyzed the dynamics of infectious diseases of separate nosologies that could be prevented using vaccination in Ukraine and Europe during 2009-2013. It was found that the proportion of infectious morbidity of the population in Ukraine holds a significant share in the overall structure of infectious morbidity in Europe. There is a growing danger of high-contagious infections like measles, rubella, mumps, pertussis, diphtheria cases

Mining modern repositories with elasticsearch

Organizations are generating, processing, and retaining data at a rate that often exceeds their ability to analyze it effec-tively; at the same time, the insights derived from these large data sets are often key to the success of the organi-zations, allowing them to better understand how to solve hard problems and thus gain competitive advantage. Be-cause this data is so fast-moving and voluminous, it is in-creasingly impractical to analyze using traditional offline, read-only relational databases. Recently, new “big data ” technologies and architectures, including Hadoop and NoSQL databases, have evolved to better support the needs of organizations analyzing such data. In particular, Elasticsearch — a distributed full-text search engine — explicitly addresses issues of scalability, big data search, and performance that relational databases were simply never designed to support. In this paper, we reflect upon our own experience with Elasticsearch and highlight its strengths and weaknesses for performing modern mining software repositories research

The contamination of Fabaceae plants with fungi and mycotoxins

This study aimed to assess the contamination of Fabaceae plants with fungi and mycotoxins, which have a negative effect on the health of consumers of plant products. Quantitative PCR was used to analyse the DNA of Alternaria, Cladosporium and Fusarium fungi in 69 plant samples harvested from four Russian regions in 2015. Additionally, mycotoxins were analysed using ELISA. Cladosporium fungi DNA was found in all the analysed samples; the occurrence of Alternaria and Fusarium DNA was 84% and 51%, respectively. Mycotoxin alternariol was detected in 100% and emodin in 90% of the samples. The occurrence of deoxynivalenol, diacetoxyscirpenol and T-2/HT-2 mycotoxins was 32%, 42% and 41%, respectively. Plant species had no significant effect on the Alternaria, Cladosporium and Fusarium DNA content of the samples; however, the alternariol, emodin, deoxynivalenol and diacetoxyscirpenol contents differed significantly between plant species. The geographical origin had a statistically significant effect on the Alternaria and Fusarium DNA contents, likely due to differences in weather conditions

Selective Changes of GABAA Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABAA channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABAA channel subunit genes in three brain regions in individuals with or without alcohol dependence using quantitative real-time PCR assay. The levels of selective GABAA channel subunit mRNAs were altered in specific brain regions in alcoholic subjects. Significant increase in the α1, α4, α5, β1, and γ1 subunit mRNAs in the hippocampal dentate gyrus region, and decrease in the β2 and δ subunit mRNAs in the orbitofrontal cortex were identified whereas no changes in the dorsolateral prefrontal cortex were detected. The data increase our understanding of the role of GABAA channels in the development of alcohol dependence

FINANCIAL RISK MANAGEMENT IN TRADE BANKS

The paper clarifies the concepts of «risk», «financial risk» in banking business, and considers the main problems of financial risk management in trade banks while financing borrowers. The authors single out the most relevant problems, and conduct the analysis of overdue payment in case of OJSC “Sberbank of Russia”. The authors also offer a number of measures to minimize financial risks in trade bank activities in modern conditions

Signaling pathways of β-cell death in type 2 diabetes mellitus: the role of innate immunity

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease, the development of which is mediated by both genetic disorders and various intracellular and extracellular molecular processes. One of the main pathogenetic mechanisms for the development of T2DM is a progressive decrease in the mass and functional reserve of β-cells, which largely determines the course of T2DM. The mechanisms of action of most sugar-lowering drugs are associated with increased secretion of insulin, so it is obvious that the effectiveness of the therapy will also largely depend on the functional state of β-cells. All this explains the great interest in studying the mechanisms of damage of β-cells in T2DM and factors that can accelerate this process, leading to their death and the development of a relative and then absolute insulin deficiency. The mechanisms of dysfunction β-cells in T2DM have not been studied much. This article provides an overview of the data of domestic and foreign literature of recent years on the molecular, intracellular features of various mechanisms of damage and death of β-cells in type 2 diabetes. The results of studies aimed at studying the possible factors and processes leading to their launch are presented

Classification of diabetes. World Health Organization 2019. What’s new?

The review focuses on the new WHO classification published in 2019. Unlike the previous classification, this classification does not recognize subtypes of T1DM and T2DM and offers new types of diabetes: “hybrid types of diabetes” and “unclassified diabetes”. This classification provides practical guidance to clinicians for assigning a type of diabetes to individuals and choose appropriate treatment (whether or not to start treatment with insulin), particularly at the time of diagnosis. This review presents the variety of forms of diabetes, the features of their clinical picture, and also emphasizes the importance of molecular genetic and immunological studies to identify types of diabetes and determine personalized therapy. The selection of “hybrid forms” of diabetes is due to the fact that the treatment of these types of diabetes has its own characteristics associated with the specific pathogenesis of diseases. However, it is obvious that further studies should relate to the study of the mechanisms of damage and decrease in the function of в-cells. Perhaps future classification systems and, as a consequence, personalized treatment will focus on various mechanisms of damage to β-cells

Influence of sodium alginate on the formation of the structure of the products from chopped and minced meat

The paper presents the results of using algae as a natural additive to chopped semi-finished meat products. The optimal ratio is set by means of the design method and the results of organoleptic assessment. The mathematical models that help to determine the optimal values of the factors and C, W and T (concentration of the components, moisture content and duration of mincing) are obtaine

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

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Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

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