Research of the immunization coverage and infectious morbidity rates in Ukraine and in the WHO European region

The article presents results of a comparative analysis of levels of immunization coverage against infectious diseases that can be prevented by routine vaccination, in Ukraine and in other countries in the European Region of WHO. It was found that starting from 2010 immunization coverage decreased in Ukraine. None of the infectious nosology achieved the WHO recommended level of 95% immunization coverage in 2013.It was analyzed the dynamics of infectious diseases of separate nosologies that could be prevented using vaccination in Ukraine and Europe during 2009-2013. It was found that the proportion of infectious morbidity of the population in Ukraine holds a significant share in the overall structure of infectious morbidity in Europe. There is a growing danger of high-contagious infections like measles, rubella, mumps, pertussis, diphtheria cases

Mining modern repositories with elasticsearch

Organizations are generating, processing, and retaining data at a rate that often exceeds their ability to analyze it effec-tively; at the same time, the insights derived from these large data sets are often key to the success of the organi-zations, allowing them to better understand how to solve hard problems and thus gain competitive advantage. Be-cause this data is so fast-moving and voluminous, it is in-creasingly impractical to analyze using traditional offline, read-only relational databases. Recently, new “big data ” technologies and architectures, including Hadoop and NoSQL databases, have evolved to better support the needs of organizations analyzing such data. In particular, Elasticsearch — a distributed full-text search engine — explicitly addresses issues of scalability, big data search, and performance that relational databases were simply never designed to support. In this paper, we reflect upon our own experience with Elasticsearch and highlight its strengths and weaknesses for performing modern mining software repositories research

The contamination of Fabaceae plants with fungi and mycotoxins

This study aimed to assess the contamination of Fabaceae plants with fungi and mycotoxins, which have a negative effect on the health of consumers of plant products. Quantitative PCR was used to analyse the DNA of Alternaria, Cladosporium and Fusarium fungi in 69 plant samples harvested from four Russian regions in 2015. Additionally, mycotoxins were analysed using ELISA. Cladosporium fungi DNA was found in all the analysed samples; the occurrence of Alternaria and Fusarium DNA was 84% and 51%, respectively. Mycotoxin alternariol was detected in 100% and emodin in 90% of the samples. The occurrence of deoxynivalenol, diacetoxyscirpenol and T-2/HT-2 mycotoxins was 32%, 42% and 41%, respectively. Plant species had no significant effect on the Alternaria, Cladosporium and Fusarium DNA content of the samples; however, the alternariol, emodin, deoxynivalenol and diacetoxyscirpenol contents differed significantly between plant species. The geographical origin had a statistically significant effect on the Alternaria and Fusarium DNA contents, likely due to differences in weather conditions

Selective Changes of GABAA Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABAA channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABAA channel subunit genes in three brain regions in individuals with or without alcohol dependence using quantitative real-time PCR assay. The levels of selective GABAA channel subunit mRNAs were altered in specific brain regions in alcoholic subjects. Significant increase in the α1, α4, α5, β1, and γ1 subunit mRNAs in the hippocampal dentate gyrus region, and decrease in the β2 and δ subunit mRNAs in the orbitofrontal cortex were identified whereas no changes in the dorsolateral prefrontal cortex were detected. The data increase our understanding of the role of GABAA channels in the development of alcohol dependence

Influence of sodium alginate on the formation of the structure of the products from chopped and minced meat

The paper presents the results of using algae as a natural additive to chopped semi-finished meat products. The optimal ratio is set by means of the design method and the results of organoleptic assessment. The mathematical models that help to determine the optimal values of the factors and C, W and T (concentration of the components, moisture content and duration of mincing) are obtaine

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Peer reviewe

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Peer reviewe

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Peer reviewe