545 research outputs found
Stimulated Brillouin Scattering Phase Conjugate Mirror and its Application to Coherent Beam Combined Laser System Producing a High Energy, High Power, High Beam Quality, and High Repetition Rate Output
Motivation and perception of Hong Kong university students about social media news
With the prevalence of social media in a digital age, accessing news on social media has become a daily routine of university students’ lives. However, little research has been done to examine their social media news use in detail, especially in Asian countries. To fill this gap, we aimed to examine what motivated university students to seek news on social media, to what extent they perceived they were in control of the influences of news, and whether news motives were related to their levels of news media literacy across three domains: (a) authors and audiences; (b) messages and meaning, and (c) representation and reality. One hundred and forty-seven university students from a university in Hong Kong participated. Among the four news motives, socializing was the most powerful predictor for news use on social media. Most students believed they were in control of news influences and demonstrated a high level of news media literacy, and those who believed themselves to be in control of news influences showed a higher level of news media literacy. In this sense, high news-literate students were more likely to seek news for socializing as compared to their low news-literate counterparts. Insights on educating students to use social media in a positive and smart way were discussed
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2016
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is 2016 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2016/33D1, December 2016, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2019
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is also 2019 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2019/36D1, December 2019, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of 2019 OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2015
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is 2015 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2015/32D1, December 2015, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2017
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is also 2017 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2017/34D1, December 2017, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2018
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is also 2018 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2018/35D1, December 2018, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2020
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is also 2020 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2020/37D1, December 2020, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) Report, December 2014
This Overseas Chinese Environmental Engineers and Scientists Association (OCEESA) report is 2014 Directory of Overseas Chinese Environmental Engineers and Scientists Association (OCEESA), Report number: OCEESA/JL-2014/31D1, December 2014, ISSN 1072 -7248. This report was prepared by Yung-Tse Hung, Permanent Executive Director, OCEESA. This report includes OCEESA contact information, list of OCEESA Directors, list of OCEESA past presidents, OCEESA membership data, constitutions and by laws of OCEESA (5 November 2000 edition), constitutions and by laws of OCEESA (14 February 2006 edition), constitutions and by laws of OCEESA (27 October 2013 edition), membership application form, letter from Wen-Chi Ku to confirm Yung-Tse Hung OCEESA permanent executive director, letter from Lawrence Kong-Pu Wang to confirm Yung-Tse Hung OCEESA permanent executive director
Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody
Enterovirus 71 (EV71) is the main pathogen responsible for hand, foot and mouth disease with severe neurological complications and even death in young children. We have recently identified a highly potent anti-EV71 neutralizing monoclonal antibody, termed D5. Here we investigated the structural basis for recognition of EV71 by the antibody D5. Four three-dimensional structures of EV71 particles in complex with IgG or Fab of D5 were reconstructed by cryo-electron microscopy (cryo-EM) single particle analysis all at subnanometer resolutions. The most critical EV71 mature virion-Fab structure was resolved to a resolution of 4.8 Å, which is rare in cryo-EM studies of virus-antibody complex so far. The structures reveal a bivalent binding pattern of D5 antibody across the icosahedral 2-fold axis on mature virion, suggesting that D5 binding may rigidify virions to prevent their conformational changes required for subsequent RNA release. Moreover, we also identified that the complementary determining region 3 (CDR3) of D5 heavy chain directly interacts with the extremely conserved VP1 GH-loop of EV71, which was validated by biochemical and virological assays. We further showed that D5 is indeed able to neutralize a variety of EV71 genotypes and strains. Moreover, D5 could potently confer protection in a mouse model of EV71 infection. Since the conserved VP1 GH-loop is involved in EV71 binding with its uncoating receptor, the scavenger receptor class B, member 2 (SCARB2), the broadly neutralizing ability of D5 might attribute to its inhibition of EV71 from binding SCARB2. Altogether, our results elucidate the structural basis for the binding and neutralization of EV71 by the broadly neutralizing antibody D5, thereby enhancing our understanding of antibody-based protection against EV71 infection. © 2016 Ye et al
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