Evolution of mechanical parameters of Shuangjiangkou granite under different loading cycles and stress paths

Surrounding rocks at different locations are generally subjected to different stress paths during the process of deep hard rock excavation. In this study, to reveal the mechanical parameters of deep surrounding rock under different stress paths, a new cyclic loading and unloading test method for controlled true triaxial loading and unloading and principal stress direction interchange was proposed, and the evolution of mechanical parameters of Shuangjiangkou granite under different stress paths was studied, including the deformation modulus, elastic deformation increment ratios, fracture degree, cohesion and internal friction angle. Additionally, stress path coefficient was defined to characterize different stress paths, and the functional relationships among the stress path coefficient, rock fracture degree difference coefficient, cohesion and internal friction angle were obtained. The results show that during the true triaxial cyclic loading and unloading process, the deformation modulus and cohesion gradually decrease, while the internal friction angle gradually increases with increasing equivalent crack strain. The stress path coefficient is exponentially related to the rock fracture degree difference coefficient. As the stress path coefficient increases, the degrees of cohesion weakening and internal friction angle strengthening decrease linearly. During cyclic loading and unloading under true triaxial principal stress direction interchange, the direction of crack development changes, and the deformation modulus increases, while the cohesion and internal friction angle decrease slightly, indicating that the principal stress direction interchange has a strengthening effect on the surrounding rocks. Finally, the influences of the principal stress interchange direction on the stabilities of deep engineering excavation projects are discussed

A Colorimetric Assay for the Detection of Glucose and H2O2 Based on Cu-Ag/g-C3N4/ZIF Hybrids with Superior Peroxidase Mimetic Activity

In this work, we report the synthesis of Cu-Ag bimetallic nanopartiles and g-C3N4 nanosheets decorated on zeolitic imidazolate framework-8 (ZIF-8) to form a Cu-Ag/g-C3N4/ZIF hybrid. The hybrid was synthesized and characterized by Transmission electron microscopy (TEM), Fourier transformed infrared (FTIR), the X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The Cu-Ag/g-C3N4/ZIF hybrid has intrinsic peroxidaselike catalytic activity towards the oxidation of TMB in the presence of H2O2. The situ synthesis of Cu-Ag bimetallic nanopartiles on 2D support such as g-C3N4 nanosheets would significantly enhance the peroxidaselike catalytic properties of individual Cu-Ag bimetallic nanopartiles and the g-C3N4 nanosheets. After loading of Cu-Ag bimetallic nanopartiles and g-C3N4 nanosheets on the ZIF-8, the hybrids exhibited superior peroxidaselike catalytic activity and good recyclability. Then, this method was applied for detecting glucose in human serum, owing the significant potential for detection of metabolites with H2O2-generation reactions

Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation

Surgical resection remains the most common method of tumor treatment; however, the high recurrence and metastasis after surgery need to be solved urgently. Herein, we report an injectable zwitterionic hydrogel based on “thiol-ene” click chemistry containing doxorubicin (DOX) and a macrophage membrane (MM)-coated 1-methyl-tryptophan (1-MT)-loaded polyamide-amine dendrimer (P-DOX/1MT) for preventing the postoperative recurrence of tumors. The results indicated that P-DOX/1MT@MM exhibited enhanced recognition and uptake of the dendrimer by tumor cells and induced the immunogenic cell death. In the mice tumor model, the P-DOX/1MT@MM-Gel exhibited high therapeutic efficiency, which could significantly reduce the recurrence of the tumor, including suppressing tumor growth, promoting dendritic cell maturation, and increasing tumor-infiltrating cytotoxic T lymphocytes. The mechanism analysis revealed that the hydrogel greatly reduces the side effects to normal tissues and significantly improves its therapeutic effect. 1MT in the hydrogel is released more rapidly, improving the tumor suppressor microenvironment and increasing the tumor cell sensitivity to DOX. Then, the DOX in the P-DOX/1MT@MM effectively eliminatedo the residual tumor cells and exerted enhanced toxicity. In conclusion, this novel injectable hydrogel that combines chemotherapy and immunotherapy has the property of sequential drug release and is a promising strategy for preventing the postoperative recurrence of tumors