Pulsations and Long-Term Light Variability of Three Candidates to Protoplanetary Nebulae

We present new photometric data and analysis of the long-duration UBV photoelectric observations for three candidates to protoplanetary objects - F-supergiants with IR-excesses located at large galactic latitudes, IRAS 18095+2704, IRAS 19386+0155, and IRAS 19500-1709. All three stars have revealed quasiperiodic low-amplitude variabilities caused by pulsations observed against the long-term trends of brightnesses. For IRAS 18095+2704=V887 Her we have found a pulsation period of 109 days and a linear trend of brightness under the constant colours if being averaged over the year timescale. The light curve of IRAS 19386+0155=V1648 Aql over 2000-2008 can be approximated by a wave with a main period of 102 days which is modulated by close frequency, with a period of 98 days, that results in brightness oscillations with a variable amplitude. V1648 Aql has also shown synchronous reddening together with a persistent rise of brightness in the V-band. IRAS 19500-1709=V5112 Sgr experiences irregular pulsations with the periods of 39 and 47 days. The long-term component of the variability of V5112 Sgr may be related to the binary character of this star.Comment: 11 pages, 6 figures, accepted for publication in Pis'ma Astron. Z

Indifference

The matter of indifference is always relevant. Almost everyone has ever experienced it in relation to the difficulties of other people, even to the loved ones. Perhaps, a man is organized in such a way that firstly he is oriented on solving his own problems and only then on difficulties of close people. But you will not spend a lot of time and money on being responsive as it is more important to be kind, compassionate, ready to share the warmth of your soul with people in need.Тема равнодушия актуальна во все времена. Вероятно, каждый из нас хоть раз проявлял равнодушие по отношению к трудностям близких. Возможно, человек так устроен, что он склонен сначала решить собственные проблемы, а неприятности близких откладывает на второй план. Скорее всего, так мы просто пытаемся найти оправдание нашей слабости, нежеланию оказать внимание и поддержку близким людям. Отзывчивость тесно связана со способностью проявлять милосердие, сострадать. Иметь доброе сердце – не значит тратить много денег. Гораздо важнее отдавать теплоту своей души, уважать, ценить – всё это умения отзывчивого человека

Iron metabolism in tuberculosis and iron-containing chemotherapeutic drugs for its treatment

This review included the Russian and international articles on the iron metabolism in tuberculosis and the use of iron-containing drugs in the treatment of tuberculosis over the past 20 years. The main topics covered by the researchers include the features of iron metabolism in mycobacteria, the varieties and pathogenesis of anemia that can develop in tuberculosis: iron deficiency (absolute iron deficiency), associated with a chronic disease (relative iron deficiency) or drug-induced anemia (siderohrestic, hemolytic, aplastic). The possible correction of treatment regimens for tuberculosis is analyzed with the introduction of a complex compound of iron with isoniazid in order to reduce undesirable adverse reactions to isoniazid . The literature search for this review was performed using the RSCI, CyberLeninka, Scopus, Web of Science, MedLine, PubMed databases

Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications

BACKGROUND Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. DESIGN This was a prospective international 1-week observational study using the ‘Assess Respiratory Risk in Surgical Patients in Catalonia risk score’ (ARISCAT score) for PPC for risk stratification. PATIENTS AND SETTING Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. MAIN OUTCOME MEASURES The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. RESULTS A total of 9864 patients fulfilled the inclusion criteria. The incidence of patients at increased risk was 28.4%. The most frequently chosen tidal volume (VT) size was 500 ml, or 7 to 9 ml kg1 predicted body weight, slightly lower in patients at increased risk of PPCs. Levels of positive end-expiratory pressure (PEEP) were slightly higher in patients at increased risk of PPCs, with 14.3% receiving more than 5 cmH2O PEEP compared with 7.6% in patients at low risk of PPCs (P < 0.001). Patients with a predicted preoperative increased risk of PPCs developed PPCs more frequently: 19 versus 7%, relative risk (RR) 3.16 (95% confidence interval 2.76 to 3.61), P < 0.001) and had longer hospital stays. The only ventilatory factor associated with the occurrence of PPCs was the peak pressure. CONCLUSION The incidence of patients with a predicted increased risk of PPCs is high. A large proportion of patients receive high VT and low PEEP levels. PPCs occur frequently in patients at increased risk, with worse clinical outcome

Risks associated with the ethical aspects of conducting clinical trials

Conducting of clinical trials is closely associated with the ethical justification, with ensuring the rights and safety of the subjects participating in them. Only through trials, it becomes possible to obtain reliable data for the inclusion of new drugs in practice, which are designed to save millions of lives. In the constantly developing field of clinical research, science does not stand still and it becomes necessary to conduct more and more new research: pediatric, geriatric, biomedical products and research involving acute social problems, and of course they all involve certain risks during their implementation. The question of the ethics of conducting research in the context of the COVID-19 pandemic is very relevant at the moment, when it is necessary to make quick decisions in the interests of all mankind, assessing all possible risks that they may entail

PROGNOSTIC SIGNIFICANCE OF TISSUE DOPPLER IMAGING IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

Objective: to assess the value of tissue Doppler (TD) imaging in predicting the clinical course of patients with hypertrophic cardiomyopathy (HCM). Materials and Methods: clinical and demographic data were analyzed in 212 subjects with HCM (141 males and 107 females, mean-age 45 yo). Median follow-up was 3,2 years (0,7-12,5 years). Patients were stratified into two groups: with present or absent adverse outcomes. Results: over the follow-up period, 7 fatal cases were registered due to SCD, and 4 successfully resuscitated subjects who experienced SCD received implantable pacemaker, 6 patients developed a stroke, cardiovascular death (1 patient) or hospitalization due to worsening of heart failure symptoms developed 7 patients. A statistically significant factor associated with adverse outcomes in cohort examined was возраст (OR 0,94; 95% CI 0,90 -0,98;

Software of the Educational Process in the Preparation of Students of Secondary Vocational Education

В данной статье рассматривается вопрос необходимости составления электронных справочников по ознакомлению обучающихся с программами, которые не рассматриваются в учебном процессе, но могут существенно изменить сам процесс обучения и дополнить его.This article discusses the issue of the need to compile electronic reference books to familiarize students with programs that are not considered in the educational process, but can signifi cantly change the learning process itself and supplement it

Rearrangement of the RNA polymerase subunit H and the lower jaw in archaeal elongation complexes

The lower jaws of archaeal RNA polymerase and eukaryotic RNA polymerase II include orthologous subunits H and Rpb5, respectively. The tertiary structure of H is very similar to the structure of the C-terminal domain of Rpb5, and both subunits are proximal to downstream DNA in pre-initiation complexes. Analyses of reconstituted euryarchaeal polymerase lacking subunit H revealed that H is important for open complex formation and initial transcription. Eukaryotic Rpb5 rescues activity of the ΔH enzyme indicating a strong conservation of function for this subunit from archaea to eukaryotes. Photochemical cross-linking in elongation complexes revealed a striking structural rearrangement of RNA polymerase, bringing subunit H near the transcribed DNA strand one helical turn downstream of the active center, in contrast to the positioning observed in preinitiation complexes. The rearrangement of subunits H and A′′ suggest a major conformational change in the archaeal RNAP lower jaw upon formation of the elongation complex