Problems and prospects of development of ecological tourism in Ireland

The paper presents the research on the development of ecological tourism in Ireland. The basic directions and problems of development of ecotourism. Income from ecotourism in the country was analyzed in the article, as well as the model for the attraction of tourists to Irelan

STANDARDIZATION OF METHODS OF CORROSION PROTECTION IN THE OIL REFINING COMPLEX

Nowadays, many industries suffer losses from the failure of technical products due to damage to products and materials resulting from corrosion. The cause of corrosion is not only exposure to the external environment, but it can also be early aging of the metal, bio-damage. As a result, modern equipment manufacturers are finding more and more technologically effective ways to combat corrosion. All methods of protection used must be regulated. Therefore, one of the most effective ways to solve the problems of protecting metals from corrosion is their comprehensive standardization. This paper will consider a set of standards used in the manufacture of equipment to protect it from corrosion and aging.В настоящее время многие предприятия несут потери из-за выхода из строя оборудования, возникающего в результате коррозии. Причиной коррозии является не только воздействие внешней среды, но и раннее старение металла, биоповреждения. Вследствие чего современные производители оборудования находят все более технологически эффективные способы борьбы с коррозией. Все используемые способы защиты должны быть регламентированы и нормированы. Поэтому, одним из эффективных путей решения вопросов защиты металлов от коррозии, является их комплексная стандартизация. В данной работе будет рассмотрен комплекс стандартов, применяемых в производстве оборудования для защиты его от коррозии и старения

Subaru optical observations of the old pulsar PSR B0950+08

We report the B band optical observations of an old (17.5 Myr) radiopulsar PSR B0950+08 obtained with the Suprime-Cam at the Subaru telescope. We detected a faint object, B=27.07(16). Within our astrometrical accuracy it coincides with the radio position of the pulsar and with the object detected earlier by Pavlov et al. (1996) in UV with the HST/FOC/F130LP. The positional coincidence and spectral properties of the object suggest that it is the optical counterpart of PSR B0950+08. Its flux in the B band is two times higher than one would expect from the suggested earlier Rayleigh-Jeans interpretation of the only available HST observations in the adjacent F130LP band. Based on the B and F130LP photometry of the suggested counterpart and on the available X-ray data we argue in favour of nonthermal origin of the broad-band optical spectrum of PSR B0950+08, as it is observed for the optical emission of the younger, middle-aged pulsars PSR B0656+14 and Geminga. At the same time, the optical efficiency of PSR B0950+08, estimated from its spin-down power and the detected optical flux, is by several orders of magnitude higher than for these pulsars, and comparable with that for the much younger and more energetic Crab pulsar. We cannot exclude the presence of a compact, about 1'', faint pulsar nebula around PSR B0950+08, elongated perpendicular to the vector of its proper motion, unless it is not a projection of a faint extended object on the pulsar position.Comment: 8 pages, LaTeX, aa.cls style, 5 PS figures, submitted to A&A. Image is available in FITS format at http://www.ioffe.rssi.ru/astro/NSG/obs/0950-subar

EVALUATION OF ENERGY EFFICIENCY ACTIVITIES SAVINGS FUEL AND ENERGY RESOURCES IN THE METALLURGICAL INDUSTRY

This article discusses the most important areas of measures for energy saving and energy efficiency in aluminum production. The main factors affecting the efficiency of metallurgical industry enterprises are presented.В данной статье рассмотрены важнейшие направления мероприятий по энергосбережению и повышению энергоэффективности в алюминиевом производстве. Представлены основные факторы, влияющие на эффективность работы предприятий металлургической отрасли промышленности

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell compartment. Quiescence of leukemic stem cells has been suggested as a mechanism conferring insensitivity to imatinib, and exposure to the Granulocyte-Colony Stimulating Factor (G-CSF), together with imatinib, has led to a significant reduction in leukemic stem cells in vitro. In this paper, we design a novel mathematical model of stem cell quiescence to investigate the treatment response to imatinib and G-CSF. We find that the addition of G-CSF to an imatinib treatment protocol leads to observable effects only if the majority of leukemic stem cells are quiescent; otherwise it does not modulate the leukemic cell burden. The latter scenario is in agreement with clinical findings in a pilot study administering imatinib continuously or intermittently, with or without G-CSF (GIMI trial). Furthermore, our model predicts that the addition of G-CSF leads to a higher risk of resistance since it increases the production of cycling leukemic stem cells. Although the pilot study did not include enough patients to draw any conclusion with statistical significance, there were more cases of progression in the experimental arms as compared to continuous imatinib. Our results suggest that the additional use of G-CSF may be detrimental to patients in the clinic

Optimizing Combination Therapies with Existing and Future CML Drugs

Small-molecule inhibitors imatinib, dasatinib and nilotinib have been developed to treat Chromic Myeloid Leukemia (CML). The existence of a triple-cross-resistant mutation, T315I, has been a challenging problem, which can be overcome by finding new inhibitors. Many new compounds active against T315I mutants are now at different stages of development. In this paper we develop an algorithm which can weigh different combination treatment protocols according to their cross-resistance properties, and find the protocols with the highest probability of treatment success. This algorithm also takes into account drug toxicity by minimizing the number of drugs used, and their concentration. Although our methodology is based on a stochastic model of CML microevolution, the algorithm itself does not require measurements of any parameters (such as mutation rates, or division/death rates of cells), and can be used by medical professionals without a mathematical background. For illustration, we apply this algorithm to the mutation data obtained in [1], [2]

New Studies of the Pulsar Wind Nebula in the Supernova Remnant CTB 80

We investigated the kinematics of the pulsar wind nebula (PWN) associated with PSR B1951+32 in the old supernova remnant CTB 80 using the Fabry-Perot interferometer of the 6m Special Astrophysical Observatory telescope. In addition to the previously known expansion of the system of bright filaments with a velocity of 100-200km/s, we detected weak high-velocity features in the H-alpha line at least up to velocities of 400-450km/s. We analyzed the morphology of the PWN in the H-alpha, [SII], and [OIII] lines using HST data and discuss its nature. The shape of the central filamentary shell, which is determined by the emission in the [OIII] line and in the radio continuum, is shown to be consistent with the bow-shock model for a significant (about 60 degrees) inclination of the pulsar's velocity vector to the plane of the sky. In this case, the space velocity of the pulsar is twice higher than its tangential velocity, i.e., it reaches ~500 km/s, and PSR B1951+32 is the first pulsar whose line-of-sight velocity (of about 400 km/s) has been estimated from the PWN observations. The shell-like H-alpha-structures outside the bow shock front in the east and the west may be associated with both the pulsar's jets and the pulsar-wind breakthrough due to the layered structure of the extended CTB 80 shell.Comment: to appear in Astronomy Letters, 12 pages, 6 postscript figures, two in colour; for a version with high resolution figures see http://www.sao.ru/hq/grb/team/vkom/CTB80_fine.pd

Adenine, guanine and pyridine nucleotides in blood during physical exercise and restitution in healthy subjects

Maximal physical exertion is accompanied by increased degradation of purine nucleotides in muscles with the products of purine catabolism accumulating in the plasma. Thanks to membrane transporters, these products remain in an equilibrium between the plasma and red blood cells where they may serve as substrates in salvage reactions, contributing to an increase in the concentrations of purine nucleotides. In this study, we measured the concentrations of adenine nucleotides (ATP, ADP, AMP), inosine nucleotides (IMP), guanine nucleotides (GTP, GDP, GMP), and also pyridine nucleotides (NAD, NADP) in red blood cells immediately after standardized physical effort with increasing intensity, and at the 30th min of rest. We also examined the effect of muscular exercise on adenylate (guanylate) energy charge—AEC (GEC), and on the concentration of nucleosides (guanosine, inosine, adenosine) and hypoxanthine. We have shown in this study that a standardized physical exercise with increasing intensity leads to an increase in IMP concentration in red blood cells immediately after the exercise, which with a significant increase in Hyp concentration in the blood suggests that Hyp was included in the IMP pool. Restitution is accompanied by an increase in the ATP/ADP and ADP/AMP ratios, which indicates an increase in the phosphorylation of AMP and ADP to ATP. Physical effort applied in this study did not lead to changes in the concentrations of guanine and pyridine nucleotides in red blood cells

Nonlinear deterministic equations in biological evolution

We review models of biological evolution in which the population frequency changes deterministically with time. If the population is self-replicating, although the equations for simple prototypes can be linearised, nonlinear equations arise in many complex situations. For sexual populations, even in the simplest setting, the equations are necessarily nonlinear due to the mixing of the parental genetic material. The solutions of such nonlinear equations display interesting features such as multiple equilibria and phase transitions. We mainly discuss those models for which an analytical understanding of such nonlinear equations is available.Comment: Invited review for J. Nonlin. Math. Phy

Niche as a determinant of word fate in online groups

Patterns of word use both reflect and influence a myriad of human activities and interactions. Like other entities that are reproduced and evolve, words rise or decline depending upon a complex interplay between {their intrinsic properties and the environments in which they function}. Using Internet discussion communities as model systems, we define the concept of a word niche as the relationship between the word and the characteristic features of the environments in which it is used. We develop a method to quantify two important aspects of the size of the word niche: the range of individuals using the word and the range of topics it is used to discuss. Controlling for word frequency, we show that these aspects of the word niche are strong determinants of changes in word frequency. Previous studies have already indicated that word frequency itself is a correlate of word success at historical time scales. Our analysis of changes in word frequencies over time reveals that the relative sizes of word niches are far more important than word frequencies in the dynamics of the entire vocabulary at shorter time scales, as the language adapts to new concepts and social groupings. We also distinguish endogenous versus exogenous factors as additional contributors to the fates of words, and demonstrate the force of this distinction in the rise of novel words. Our results indicate that short-term nonstationarity in word statistics is strongly driven by individual proclivities, including inclinations to provide novel information and to project a distinctive social identity.Comment: Supporting Information is available here: http://www.plosone.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.pone.0019009.s00