An Analysis of the Clear Horizons Program in Perry County, Kentucky on Smoking Cessation

Perry County is an Appalachian county located in southeastern Kentucky. The population is 28,473 people (United States Census Bureau, 2020). It is a predominately white community, with 95.9% of people falling in this category, which is higher than the national percentage of 75.8% (United States Census Bureau, 2020). Being a rural county, this community uses few news sources, with the primary outlet being WYMT Eastern Kentucky News. This news outlet is a subset of CBS (WYMT, 2023). When comparing statewide and nationwide data, Perry County does consistently worse. They have a high school graduation rate that is lower than the state and national average. Perry County’s rate is 77.8%, in comparison to 87.7% in Kentucky and 88.9% in the United States (American Community Survey, 2017-2021). The unemployment rate is also higher, which could indicate a lack of employment opportunities. Perry County is 5.1%, the United States is 3.5%, and the state’s is 3.7% (Federal Reserve Economic Data, 2022). Citizens of Perry County face financial hardship, as many of them are living in poverty. 29.9% of people living in Perry County are living in poverty, in comparison to 16.5% in Kentucky and 11.6% at the national level (United States Census Bureau, 2020). Poverty rates directly connect to household income. The median household income in Perry County is $40,577, which is almost$20,000 lower than the national average (United States Census Bureau, 2020

How to deal with negative online employer reviews: An application of image repair theory

Although negative employer reviews pose a threat to employers by reducing organizational attractiveness, employers can respond to reviews to avert these threats. However, we lack a clear understanding of the response strategies and factors that determine response strategies' impact. To address this issue, we introduce image repair theory (IRT) as a promising theoretical foundation in the study of employer response. Using an experimental design, we tested the effects of IRT's general image repair strategies (i.e., Denial, Evasion of Responsibility, Reducing Offensiveness, Corrective Action, and Mortification) and the mechanisms underlying these effects according to IRT. Moreover, we explored the role of review content (i.e., the type of employer image information the review entails) as a contingency factor. We found differences between Denial, Corrective Action, and Mortification, which show that the choice of response strategies can matter and that the relationship between response strategy and potential applicants' perceptions of organizational attractiveness is mediated by attributions of responsibility rather than by perceived offensiveness. In addition, our results suggest that when negative reviews contain information about instrumental rather than symbolic employer image attributes, potential applicants can attribute more responsibility to the employer. Furthermore, only the effects of Reducing Offensiveness and Mortification were dependent on the review's content. We discuss theoretical implications and practical recommendations for employers that respond to negative employer reviews

Nutrition as the Foundation for Good Health: Evaluating the Impact of Food Programs on Health

Introduction. Previous studies have demonstrated a link between food insecurity and childhood behavioral problems, particularly internal problems such as anxiety and depression. Burlington Children’s Space (BCS), a local preschool and daycare in Burlington, VT, has created a healthy and nutritious meal program for their children, many of whom cannot afford enough to eat well at home.https://scholarworks.uvm.edu/comphp_gallery/1194/thumbnail.jp

A Community Model to Improve Physical Activity in Children

Introdction: • The prevalence of overweight / obese children aged 2-5 in the United States is 21.2%. The National Center of Health Statistics estimates a 30% increase in the prevalence of obesity between 2001 and 2004. • The Vermont Department of Health estimates that about 30% of low income children between 2 and 5 years of age are overweight or at risk of becoming overweight. • Physical activity programming at child care centers is the most important predictor of physical activity in preschool-aged children, more important than the child’s socioeconomic and demographic characteristics. • Although the National Association for Sports and Physical Education offers some guidelines, there are no clear recommendations for physical activity in childcare settings in Vermont and nationwide.https://scholarworks.uvm.edu/comphp_gallery/1067/thumbnail.jp

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species

<p>Abstract</p> <p>Background</p> <p>The farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR) are three closely related nuclear hormone receptors in the NR1H and 1I subfamilies that share the property of being activated by bile salts. Bile salts vary significantly in structure across vertebrate species, suggesting that receptors binding these molecules may show adaptive evolutionary changes in response. We have previously shown that FXRs from the sea lamprey (<it>Petromyzon marinus</it>) and zebrafish (<it>Danio rerio</it>) are activated by planar bile alcohols found in these two species. In this report, we characterize FXR, PXR, and VDR from the green-spotted pufferfish (<it>Tetraodon nigriviridis</it>), an actinopterygian fish that unlike the zebrafish has a bile salt profile similar to humans. We utilize homology modelling, docking, and pharmacophore studies to understand the structural features of the <it>Tetraodon </it>receptors.</p> <p>Results</p> <p><it>Tetraodon </it>FXR has a ligand selectivity profile very similar to human FXR, with strong activation by the synthetic ligand GW4064 and by the primary bile acid chenodeoxycholic acid. Homology modelling and docking studies suggest a ligand-binding pocket architecture more similar to human and rat FXRs than to lamprey or zebrafish FXRs. <it>Tetraodon </it>PXR was activated by a variety of bile acids and steroids, although not by the larger synthetic ligands that activate human PXR such as rifampicin. Homology modelling predicts a larger ligand-binding cavity than zebrafish PXR. We also demonstrate that VDRs from the pufferfish and Japanese medaka were activated by small secondary bile acids such as lithocholic acid, whereas the African clawed frog VDR was not.</p> <p>Conclusions</p> <p>Our studies provide further evidence of the relationship between both FXR, PXR, and VDR ligand selectivity and cross-species variation in bile salt profiles. Zebrafish and green-spotted pufferfish provide a clear contrast in having markedly different primary bile salt profiles (planar bile alcohols for zebrafish and sterically bent bile acids for the pufferfish) and receptor selectivity that matches these differences in endogenous ligands. Our observations to date present an integrated picture of the co-evolution of bile salt structure and changes in the binding pockets of three nuclear hormone receptors across the species studied.</p

Applications of a patient-specific whole-body CT-mesh hybrid computational phantom in second cancer risk prediction

Objective. CT-mesh hybrid phantoms (or 'hybrid(s)') made from integrated patient CT data and mesh-type reference computational phantoms (MRCPs) can be beneficial for patient-specific whole-body dose evaluation, but this benefit has yet to be evaluated for second cancer risk prediction. The purpose of this study is to compare the hybrid's ability to predict risk throughout the body with a patient-scaled MRCP against ground truth whole-body CTs (WBCTs). Approach. Head and neck active scanning proton treatment plans were created for and simulated on seven hybrids and the corresponding scaled MRCPs and WBCTs. Equivalent dose throughout the body was calculated and input into five second cancer risk models for both excess absolute and excess relative risk (EAR and ERR). The hybrid phantom was evaluated by comparing equivalent dose and risk predictions against the WBCT. Main results. The hybrid most frequently provides whole-body second cancer risk predictions which are closer to the ground truth when compared to a scaled MRCP alone. The performance of the hybrid relative to the scaled MRCP was consistent across ERR, EAR, and all risk models. For all in-field organs, where the hybrid shares the WBCT anatomy, the hybrid was better than or equal to the scaled MRCP for both equivalent dose and risk prediction. For out-of-field organs across all patients, the hybrid's equivalent dose prediction was superior than the scaled MRCP in 48% of all comparisons, equivalent for 34%, and inferior for 18%. For risk assessment in the same organs, the hybrid's prediction was superior than the scaled MRCP in 51.8% of all comparisons, equivalent in 28.6%, and inferior in 19.6%. Significance. Whole-body risk predictions from the CT-mesh hybrid have shown to be more accurate than those from a reference phantom alone. These hybrids could aid in risk-optimized treatment planning and individual risk assessment to minimize second cancer incidence

Evolutionary Origin of the Interferon-Immune Metabolic Axis: The Sterol-Vitamin D Link

In vertebrate animals, the sterol metabolic network is emerging as a central player in immunity and inflammation. Upon infection, flux in the network is acutely moderated by the interferon (IFN) response through direct molecular and bi-directional communications. How sterol metabolism became linked to IFN control and for what purpose is not obvious. Here, we deliberate on the origins of these connections based on a systematic review of the literature. A narrative synthesis of publications that met eligibility criteria allowed us to trace an evolutionary path and functional connections between cholesterol metabolism and immunity. The synthesis supports an ancestral link between toxic levels of cholesterol-like products and the vitamin D receptor (VDR). VDR is an ancient nuclear hormone receptor that was originally involved in the recognition and detoxification of xenobiotic marine biotoxins exhibiting planar sterol ring scaffolds present in aquatic environments. Coadaptation of this receptor with the acquisition of sterol biosynthesis and IFNs in vertebrate animals set a stage for repurposing and linking a preexisting host-protection mechanism of harmful xenobiotics to become an important regulator in three key interlinked biological processes: bone development, immunity, and calcium homeostasis. We put forward the hypothesis that sterol metabolites, especially oxysterols, have acted as evolutionary drivers in immunity and may represent the first example of small-molecule metabolites linked to the adaptive coevolution and diversification of host metabolic and immune regulatory pathways