Anhang

Anhangsverzeichnis Wissenschaftlicher Bericht Teil 1 und Teil

Целесообразность применения биомедицинских клеточных продуктов у пациентов с синдромом диабетической стопы (обзор литературы)

Today, the rapid and cost-effective treatment of patients with diabetic foot syndrome (DFS) is still challenging. The use of biomedical cell products (BCP) in this patients category has a clear pathogenetic orientation, but it remains not fully understood and generally accepted. The review presents the results of numerous studies confirming the efficacy of BCP for the treatment of predominantly superficial trophic defects in patients with neuropathic DFS. However, these technologies are still classified as adjuvant therapies. There are no clear algorithms and regulations for the use of BCP. It has been shown that their use accelerates the reparative processes in superficial trophic defects in patients with neuropathic DFS in combination with standard therapy and shortens the time of wound epithelialization. Considering the laboriousness and high cost of BCPs, the possibility of their use for the treatment of patients with neuroischemic form of DFS of various grades according to the WIfI classification should be considered.На сегодняшний день быстрое и экономически эффективное лечение пациентов с синдромом диабетической стопы (СДС) все еще остается сложной задачей. Применение биомедицинских клеточных продуктов (БКП) у данной категории больных имеет четкую патогенетическую направленность, однако остается не до конца изученным и общепринятым. В обзоре приведены результаты многочисленных исследований, подтверждающих эффективность применения БКП для лечения преимущественно поверхностных трофических дефектов у пациентов с нейропатической формой СДС. Тем не менее данные технологии все еще относятся к адъювантным методам терапии. Отсутствуют четкие алгоритмы и регламент использования БКП. Показано, что их применение ускоряет репаративные процессы в поверхностных трофических дефектах у пациентов с нейропатической формой СДС в комплексе со стандартной терапией и сокращает сроки эпителизации ран. Учитывая трудоемкость и высокую стоимость БКП, следует рассмотреть возможность их использования для лечения больных нейроишемической формой СДС разных градаций по классификации WIfI

Real-world evidence on the effectiveness and safety of gliclazide extended release treatment in Indian patients with type 2 diabetes undergoing Ramadan fast: an analysis from the global DIA-RAMADAN study

Context and Aim: Glycemic imbalance, especially hypoglycemia, is one of the greatest risks for patients with type 2 diabetes mellitus (T2DM) during Ramadan fasting. This paper outlines the efficacy and safety of gliclazide extended release (XR) in Indian patients with T2DM enrolled in the global DIA-RAMADAN study. Methods and Material: Adults (aged ≥18 years) with T2DM who chose to fast during Ramadan and received a gliclazide-based regimen once daily for 90 days before Ramadan were included in the study. Baseline and end-of-study visits were conducted 6–8 weeks before and 4–6 weeks after Ramadan, respectively. Primary outcome was the incidence of ≥1 symptomatic hypoglycemic event (HE). Changes in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body weight were secondary outcomes. Results: Among 246 Indian patients enrolled in the study, most (78.9%, n=194) were at moderate/low risk as per the International Diabetes Federation and Diabetes and Ramadan guidelines. Most patients (69.1%) received gliclazide XR as monotherapy, and the rest received gliclazide XR with metformin or other antidiabetic therapy. Significant reductions in HbA1c (−0.5±0.8%, P<0.001) and FPG (−21.8±59.4 mg/dL, P<0.001) levels were observed but the slight reduction in body weight was not statistically significant (−0.3±3.7 kg, P=0.614) in patients post-Ramadan. Overall, no HE was reported in Indian patients with T2DM during Ramadan fasting. Conclusion: Overall, the effectiveness and safety of gliclazide XR in Indian patients was consistent with that observed in the global cohort. Gliclazide XR significantly reduced HbA1c with no incidence of hypoglycemic events in Indian patients with type 2 diabetes undergoing Ramadan fast, suggesting that gliclazide XR may be used without dose modification at Iftar to maintain optimal glycemic control during Ramadan

Mobility in a Globalised World 2017

The term mobility has different meanings in the following science disciplines. In economics, mobility is the ability of an individual or a group to improve their eco-nomic status in relation to income and wealth within their lifetime or between gen-erations. In information systems and computer science, mobility is used for the concept of mobile computing, in which a computer is transported by a person dur-ing normal use. Logistics creates by the design of logistics networks the infrastruc-ture for the mobility of people and goods. Electric mobility is one of today’s solu-tions from an engineering perspective to reduce the need of energy resources and environmental impact. Moreover, for urban planning, mobility is the crunch ques-tion about how to optimise the different needs for mobility and how to link differ-ent transportation systems. In this publication we collected the ideas of practitioners, researchers, and gov-ernment officials regarding the different modes of mobility in a globalised world, focusing on both domestic and international issues

Mobility in a Globalised World 2013

The term mobility has different meanings in the following science disciplines. In economics, mobility is the ability of an individual or a group to improve their economic status in relation to income and wealth within their lifetime or between generations. In information systems and computer science, mobility is used for the concept of mobile computing, in which a computer is transported by a person during normal use. Logistics creates by the design of logistics networks the infrastructure for the mobility of people and goods. Electric mobility is one of today‘s solutions from engineering perspective to reduce the need of energy resources and environmental impact. Moreover, for urban planning, mobility is the crunch question about how to optimise the different needs for mobility and how to link different transportation systems. In this publication we collected the ideas of practitioners, researchers, and government officials regarding the different modes of mobility in a globalised world, focusing on both domestic and international issues. We are grateful for the academic hospitality at the Stuttgart Media University for our conference 2013 "Mobility in a globalised world" in September 2013. We would like to thank Prof. Dr Johannes Maucher and Dr. Heiko Roßnagel for their technical support during our sojourn in Stuttgart

Mobility in a Globalised World 2015

The term mobility has different meanings in the following science disciplines. In economics, mobility is the ability of an individual or a group to improve their economic status in relation to income and wealth within their lifetime or between generations. In information systems and computer science, mobility is used for the concept of mobile computing, in which a computer is transported by a person during normal use. Logistics creates by the design of logistics networks the infrastructure for the mobility of people and goods. Electric mobility is one of today’s solutions from engineering perspective to reduce the need of energy resources and environmental impact. Moreover, for urban planning, mobility is the crunch question about how to optimise the different needs for mobility and how to link different transportation systems. In this publication we collected the ideas of practitioners, researchers, and government officials regarding the different modes of mobility in a globalised world, focusing on both domestic and international issues

Mobility in a Globalised World 2016

The term mobility has different meanings in the following science disciplines. In economics, mobility is the ability of an individual or a group to improve their economic status in relation to income and wealth within their lifetime or between generations. In information systems and computer science, mobility is used for the concept of mobile computing, in which a computer is transported by a person during normal use. Logistics creates by the design of logistics networks the infrastructure for the mobility of people and goods. Electric mobility is one of today’s solutions from engineering perspective to reduce the need of energy resources and environmental impact. Moreover, for urban planning, mobility is the crunch question about how to optimise the different needs for mobility and how to link different transportation systems. In this publication we collected the ideas of practitioners, researchers, and government officials regarding the different modes of mobility in a globalised world, focusing on both domestic and international issues

Mobility in a Globalised World 2014

The term mobility has different meanings in the following science disciplines. In economics, mobility is the ability of an individual or a group to improve their economic status in relation to income and wealth within their lifetime or between generations. In information systems and computer science, mobility is used for the concept of mobile computing, in which a computer is transported by a person during normal use. Logistics creates by the design of logistics networks the infrastructure for the mobility of people and goods. Electric mobility is one of today’s solutions from engineering perspective to reduce the need of energy resources and environmental impact. Moreover, for urban planning, mobility is the crunch question about how to optimise the different needs for mobility and how to link different transportation systems. In this publication we collected the ideas of practitioners, researchers, and government officials regarding the different modes of mobility in a globalised world, focusing on both domestic and international issues