Increase psychological culture of parents as an element of psycho-pedagogical supportthe motivational readiness for school

The article deals with the psychological and pedagogical work to improve the psychological culture of parents in the run-up to the senior preschool children prepare for school. Improving psychological culture of parents is seen as a factor contributing to the development of educational motivation of children. TJiere is analysis of the psychological aspects of the culture of parents such as knowledge sensitive periods for the formation of a child certain skills, good planning process ofpreparing a child for school, the desire to cooperate with teachers and psychologists.Статья посвящена проблеме психолого-педагогической работы по повышению психологической культуры родителей старших дошкольников в преддверии подготовки к школе. Повышение психологической культуры родителей рассматривается как фактор, способствующий развитию учебной мотивации детей. Анализируются такие аспекты психологической культуры родителей как знание сенситивных периодов для формирования у ребенка определенных навыков, грамотное планирование прогресса подготовки ребенка к школе, стремление к сотрудничеству с педагогами и психологами

Spesific of educative motivation in the aspect of phenomenon of school”s fers

The article is devoted to the relatively new problem of school fears of preschoolers and their negative impact on cognitive motivation in the context of the children readiness for school. There are theoretical and methodological foundations of readiness / unreadiness to schooling, factors psychological fatigue as a result of overload with additional classes (before school entry) and fear not to disappoint the expectations of adults.Статья посвящена сравнительно новой в теории и практике проблеме возникновения школьных страхов у дошкольников и их негативного влияния на познавательную мотивацию в контексте психологической готовности ребенка к школе. Рассматриваются теоретико-методологические основы готовности/неготовности к школьному обучению, факторы психологической усталости в результате перегруженности дополнительными занятиями (еще до поступления в школу) и страх не оправдать ожидания взрослых

Study of Antibiotic Resistance of the Oropharyngeal Hemolytic Microflora in Preschool Children

It is impossible to imagine modern medical practice without antibiotic therapy. However, the rapid development of the pharmaceutical industry expands free access of the population to antibacterial drugs. At the same time, the illiteracy of people with respect to the principles of rational antibiotic therapy also increases. The problem of microbial resistance to antibacterial drugs remains relevant to this day. Special attention should be paid to rational antibiotic therapy applied to children.The purpose of this work was to study the resistance of hemolytic microorganisms, which are often the cause of upper respiratory infection in preschool children, to the main antibacterial drugs used in pediatric practice. The results of this scientific research can be advisory and useful to pediatricians and other specialists whose professional activities are related to children’s health. Keywords: hemolytic active microorganisms, bacterial carriage, antibiotic resistance, children’s healt

Bacterial Carriage of Pathogenic Antibiotic-resistant Staphylococci Among Conditionally Healthy Infants and Preschool-age Children

Staphylococci are related to opportunistic microorganisms and are part of normal human microflora. However, there are varieties that can cause pyoinflammatory diseases in organisms with weakened immune status. In the event of an inadequate therapeutic approach, they are preserved in the body, and the person becomes a bacterial carrier and a source of dissemination of pathogenic microorganisms. The formation of antibiotic resistance also plays a significant role in the emergence of bacterial carriage. The situation is especially serious in organized children’s groups, where children are in close contact with one another. Thus, the study of the prevalence rate of antibiotic resistance among pathogenic strains of staphylococci in children’s groups is topical and worthy of attention. The purpose of this work is to identify carriers of pathogenic and antibiotic resistant staphylococci isolated from the microflora of the oral cavity of preschool children considered healthy. The results of the research can prove useful in practical healthcare and, particularly, in pediatric practice. Keywords: staphylococci, pathogenic cocci, bacterial carriage, antibiotic resistance, infant morbidity rat

Socio-Economic Impact of the Creation and Operation of Mega-Science Projects

Challenges of development facing society and states require efforts consolidation, in the research field in particular. Therefore, to organize international cooperation and to conduct basic and applied research, mega-science infrastructures are being created and implemented all over the world. Currently, research facilities of the mega-science class are being created in the Russian Federation. They play an important role in the development of science and the innovation process. The competitiveness of Russian science is a determining factor for ensuring the safety and technological independence of Russia. Therefore, the Federal program for the development of Synchrotron and Neutron research and research infrastructure for 2019-2027 was approved in March 2020. In the present article, the concept of the socio-economic impact of the operation of large-scale research infrastructure is revealed. The authors refer to the materials on the socio-economic impact analysis, which was based on the data on the Swedish neutron source (European Spallation Source). The article provides a generalized idea of the main indicators for assessing the potential of the research infrastructure as well as their application to characterize the research facilities in the Russian Federation. It is worth highlighting that each large research facility is unique and it is not possible to unify the analysis of the socio-economic impact. However, the obtained results can be used for a similar analysis of research infrastructures, based on the same physical principles and created to solve general scientific problems

EWI-2 regulates α3β1 integrin–dependent cell functions on laminin-5

EWI-2, a cell surface immunoglobulin SF protein of unknown function, associates with tetraspanins CD9 and CD81 with high stoichiometry. Overexpression of EWI-2 in A431 epidermoid carcinoma cells did not alter cell adhesion or spreading on laminin-5, and had no effect on reaggregation of cells plated on collagen I (α2β1 integrin ligand). However, on laminin-5 (α3β1 integrin ligand), A431 cell reaggregation and motility functions were markedly impaired. Immunodepletion and reexpression experiments revealed that tetraspanins CD9 and CD81 physically link EWI-2 to α3β1 integrin, but not to other integrins. CD81 also controlled EWI-2 maturation and cell surface localization. EWI-2 overexpression not only suppressed cell migration, but also redirected CD81 to cell filopodia and enhanced α3β1–CD81 complex formation. In contrast, an EWI-2 chimeric mutant failed to suppress cell migration, redirect CD81 to filopodia, or enhance α3β1–CD81 complex formation. These results show how laterally associated EWI-2 might regulate α3β1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes