72 research outputs found
Tinbergen's work: Change and continuity
This article provides an overview of Tinbergen's economic writings, comprising well over 900 publications. Six broad areas have been distinguished to allow for the classification and discussion of Tinbergen's economic work. These six areas embody the change in Tinbergen's areas of interest apart from the shift from physics to economics early in his career. Tinbergen's work, however, is not only characterised by change of areas but also by continuity in approach. To mark this continuity four main characteristics of Tinbergen's work have been elaborated. The article concludes with Tinbergen's observations on the achievements to be expected from scientific research.
J. Kol was Associate Professor of International Economics and Economic Integration at the Faculty of Economics of the Erasmus University in Rotterdam; P. de Wolff is Emeritus Professor at the University of Amsterdam and was Director of the Central Planning Bureau in The Hague as successor of J. Tinbergen. The authors are grateful to Mrs. I.M. Lageweg and Mr C.J. van Opijnen for their assistance with references
The a-theorem and conformal symmetry breaking in holographic RG flows
We study holographic models describing an RG flow between two fixed points
driven by a relevant scalar operator. We show how to introduce a spurion field
to restore Weyl invariance and compute the anomalous contribution to the
generating functional in even dimensional theories. We find that the
coefficient of the anomalous term is proportional to the difference of the
conformal anomalies of the UV and IR fixed points, as expected from anomaly
matching arguments in field theory. For any even dimensions the coefficient is
positive as implied by the holographic a-theorem. For flows corresponding to
spontaneous breaking of conformal invariance, we also compute the two-point
functions of the energy-momentum tensor and the scalar operator and identify
the dilaton mode. Surprisingly we find that in the simplest models with just
one scalar field there is no dilaton pole in the two-point function of the
scalar operator but a stronger singularity. We discuss the possible
implications.Comment: 50 pages. v2: minor changes, added references, extended discussion.
v3: we have clarified some of the calculations and assumptions, results
unchanged. v4: published version in JHE
Confinement, phase transitions and non-locality in the entanglement entropy
In this paper we study the conjectural relation between confinement in a
quantum field theory and the presence of a phase transition in its
corresponding entanglement entropy. We determine the sufficient conditions for
the latter and compare to the conditions for having a confining Wilson line. We
demonstrate the relation in several examples. Superficially, it may seem that
certain confining field theories with a non-local high energy behaviour, like
the dual of D5 branes wrapping a two-cycle, do not admit the corresponding
phase transition. However, upon closer inspection we find that, through the
introduction of a regulating UV-cutoff, new eight-surface configurations
appear, that satisfy the correct concavity condition and recover the phase
transition in the entanglement entropy. We show that a local-UV-completion to
the confining non-local theories has a similar effect to that of the
aforementioned cutoff.Comment: 64 pages. Lots of figure
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
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