13 research outputs found
Ectopia cordis : a report of two cases in Cameroon
This article reports two cases of ectopia cordis in two children aged one day and twenty months respectively.
A one day old newborn had complete thoracic ectopia cordis associated with an internal cardiac
defect and severe thoracic and abdominal wall malformations. The centre does not have the
facilities to manage complex congenital defects and prior to being transferred to a cardiac centre,
the neonate died on the second day of admission. A 20-month old baby had partial ectopia of the
heart and a defect in the abdominal wall. He had no major congenital cardiac defect and has
remained clinically stable with no life threatening symptomspeer-reviewe
Assessing the baseline burden of otitis media in children 2 to 3 years of age for estimating the effecfs of 13-valent pneumococcal conjugate vaccine (PCV) on otitis media
Alarming rates of virological failure and HIV-1 drug resistance amongst adolescents living with perinatal HIV in both urban and rural settings: evidence from the EDCTP READY-study in Cameroon
Objectives: Adolescents living with perinatal HIV infection (ALPHI) experience persistently high mortality rates, particularly in resource-limited settings. It is therefore clinically important for us to understand the therapeutic response, acquired HIV drug resistance (HIVDR) and associated factors among ALPHI, according to geographical location. Methods: A study was conducted among consenting ALPHI in two urban and two rural health facilities in the Centre Region of Cameroon. World Health Organization (WHO) clinical staging, self-reported adherence, HIVDR early warning indicators (EWIs), immunological status (CD4 count) and plasma viral load (VL) were assessed. For those experiencing virological failure (VF, VL ≥ 1000 copies/mL), HIVDR testing was performed and interpreted using the Stanford HIV Drug Resistance Database v.8.9-1. Results: Of the 270 participants, most were on nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens (61.7% urban vs. 82.2% rural), and about one-third were poorly adherent (30.1% vs. 35.1%). Clinical failure rates (WHO-stage III/IV) in both settings were < 15%. In urban settings, the immunological failure (IF) rate (CD4 < 250 cells/μL) was 15.8%, statistically associated with late adolescence, female gender and poor adherence. The VF rate was 34.2%, statistically associated with poor adherence and NNRTI-based antiretroviral therapy. In the rural context, the IF rate was 26.9% and the VF rate was 52.7%, both statistically associated with advanced clinical stages. HIVDR rate was over 90% in both settings. EWIs were delayed drug pick-up, drug stock-outs and suboptimal viral suppression. Conclusions: Poor adherence, late adolescent age, female gender and advanced clinical staging worsen IF. The VF rate is high and consistent with the presence of HIVDR in both settings, driven by poor adherence, NNRTI-based regimen and advanced clinical staging
Refeeding syndrome during management of severe acute malnutrition in children: Biological aspects
P-015: A NON-INFERIORITY SINGLE-BLINDED RANDOMIZED CONTROLLED CLINICAL TRIAL ON THE EFFICACY OF ORAL MORPHINE VERSUS INJECTABLE TRAMADOL IN THE ANALGESIC MANAGEMENT OF SEVERE PAINFUL VASO-OCCLUSIVE CRISIS IN CHILDREN WITH SICKLE CELL DISEASE
Ostéo-onycho-dystrophie héréditaire chez l’enfant à propos d’un cas : intérêt diagnostique.
L’ostéo-onycho-dystrophie héréditaire (OODH) est une maladie héréditaire autosomique dominante traduisant une mutation du gène LMX1B et peu de cas ont été décrits dans la littérature. Le but de ce travail était d’ajouter ce cas rare au registre de la littérature mondiale. Les auteurs rapportent un cas vraisemblable d’osteo-onycho-dystrophie héréditaire chez un petit enfant de 3 ans avec hérédité d’onycho- dystrophie maternelle, présentant une agénésie bilatérale des rotules, un trouble de la migration testiculaire mais aucune anomalie unguéale ni atteinte rénale. La littérature est révisée. Le diagnostic d’ostéo-onycho-dystrophie héréditaire repose sur un faisceau d’arguments au premier rang desquels la mutation du gène LMX1B. On comprend mieux les difficultés diagnostiques de tels cas dans nos contrées sous-médicalisées où le bilan génétique n’est pas encore entré dans les moeurs.Mots-clés : Ostéo-onycho-dystrophie, hérédité, enfant, Yaoundé, Cameroun.English AbstractContextHeditary osteo-onychodystroplasia HOOD is an autosomal dominant heriditary disease due to a mutation of the LMX1B gene and only a few cases have been described in litterature.ObjectiveThe aim of our work was to add this rare cas to the world literature register.Cas reportSome authors report one similar cas of heriditary osteo-onychodystroplasia in a 3 years child with famillial maternal onycho-dystroplasia presenting with bilateral patella agenesis, anomaly of testicular migration ,but no nail nor renal involvement was observed. Literature was reviewed.Discussion-ConclusionThe diagnosis of heriditary osteo-onychodysplasia replies on a group of argument with mutation in LMX1B gene being at the forefront. We can then understand the diagnostic difficulties of such cases in under medicalised countries where genotypic workups are not yet routinely done.Keywords: Ostéo-onychodystroplasia, heredity, child, Yaounde, Cameroo
Assessing the baseline burden of otitis media in children 2 to 3 years of age for estimating the effecfs of 13-valent pneumococcal conjugate vaccine (PCV) on otitis media
Assessment of cardiac function in children with congenital adrenal hyperplasia: a case control study in Cameroon
Abstract Background High level of androgens found in congenital adrenal hyperplasia (CAH) seems to have a deleterious effect on heart function. We therefore evaluate cardiac function of children with CAH in comparison with a healthy group. Methods We carried out a case-control study in the single endocrinology unit of the Mother and Child Center of Chantal Biya’s Foundation. Cases were matched for age and genotypic sex to 2 healthy controls. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves velocities, E/A ratio and the mitral deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion and pulmonary artery systolic pressure were also measured. Results We included 19 patients with a median age of 6.26 ± 3.75 years and 38 controls stackable distribution. The left ventricular mass of cases was greater than that of controls. A case of reversible cardiomyopathy on hormone replacement therapy was found. For the cases, the average ejection fraction was 71.95 ± 7.88%; the average fractional shortening was 40.67 ± 7.02%. All these values ​​were higher than those of controls, although the difference was not statistically significant. Diastolic left ventricular function was more impaired among the cases. Right ventricular function was similar in both groups. These abnormalities were highly correlated to the late age at diagnosis and duration of treatment. Conclusion This study shows an altered cardiac function in CAH compared to healthy control and highlights importance of an early diagnosis of cases, a tight control of androgens levels and a regular monitoring of cardiac function
Rev Epidemiol Sante Publique
Position du problème Au Cameroun, la couverture des enfants éligibles au traitement antirétroviral (TARV) (15 %) était l’une des plus faibles des 21 pays prioritaires du Fonds Mondial en 2012. Le but de cette étude était de faire une analyse situationnelle de l’offre des soins pour améliorer la prise en charge du VIH pédiatrique (PECP) au Cameroun. Méthodes Une étude transversale descriptive a été menée pendant quatre mois (avril à août 2014) dans 12 formations sanitaires de sept régions du Cameroun sélectionnées par un sondage systématique. Les données ont été recueillies à l’aide d’un auto-questionnaire administré aux personnels soignants et aux responsables administratifs inclus dans l’étude. Résultats Au total 142 personnels en charge du VIH pédiatrique ont été inclus dans cette étude : 115 du niveau opérationnel parmi lesquels 59 (51,2 %) personnels de santé, 44 (38,3 %) agents communautaires, 12 (10,4 %) chefs de services, 19 responsables du niveau régional et 8 du niveau central. La grande majorité des personnels soignants impliqués dans la PECP étaient des infirmiers, nécessitant ainsi la délégation effective des tâches médicales institutionnalisée au Cameroun. Très peu de documents normatifs nationaux prenaient en compte la PECP. La faible vulgarisation de ces documents normatifs à tous les niveaux de la pyramide sanitaire pourrait justifier le non-respect des protocoles de prise en charge observé dans les formations sanitaires offrant la PECP. Conclusion La mise à jour et la diffusion à large échelle des documents nationaux normatifs, prenant en compte des spécificités de l’enfant infecté par le VIH, sont nécessaires pour améliorer l’application des directives de la PECP au niveau opérationnel.Background In Cameroon in 2012, the proportion (15%) of children eligible for antiretroviral treatment (ART) was one of the lowest among the 21 Global Fund priority countries. The objective of this study was to carry out a situational analysis of the existing care offer for pediatric HIV in Cameroon. Methods A descriptive cross-sectional study was conducted over a 4-month period (April to August 2014) in 12 healthcare facilities in 7 regions of Cameroon selected by systematic sampling. The data were collected in a self-administered questionnaire filled out by the caregiving and administrative personnel included in the study. Results All in all, 142 persons in charge of pediatric HIV treatment were included in the study, of whom 115 were working at the operational level: 59 (51.2%) health personnel, 44 (38.3%) community agents and 12 (10.4%) department heads; the other 27 exercised responsibilities at the regional (19) and the local (8) levels. An overwhelming majority of the caregivers involved in pediatric VIH treatment were nurses, a factor necessitating the delegation of medical tasks institutionalized in Cameroon. Few standardized nationwide documents take into account these treatment modalities. Inadequate dissemination of the documents at all levels of the healthcare pyramid may justify the non-compliance with the care protocols that has been observed in the training programs dedicated to the subject. Conclusion The updating and large-scale dissemination of standardized nationwide documents taking into account the specificities of HIV-infected children are required to improve implementation at the operational level of the Cameroonian healthcare system of the existing guidelines for pediatric HIV treatment
Intérêt du dosage de la procalcitonine sérique dans le diagnostic et le suivi des infections néonatales d'origine bactérienne à Yaoundé, Cameroun
Neonatal infection (NNI) is a public health problem in developing countries where pediatricians and specifically neonatologists encounter many diagnostic difficulties. Having a precise and easily measurable biological marker, with a high sensitivity and a high negative predictive value, that can rapidly detect NNI, remains a great challenge. The aim of this study was to determine the place of serum procalcitonin (PCT) in the diagnosis and follow-up of bacterial NNI in resource-limited contexts