介護職の虐待防止に関する研究

13301甲第4808号博士（学術）金沢大学博士論文本文Ful

介護職の虐待防止に関する研究

13301甲第4808号博士（学術）金沢大学博士論文要旨Abstrac

Supply of goods from hospitals to outpatients practicing intermittent self-catheterization in Japan

Hospitals supply goods to patients practicing intermittent self-catheterization (ISC), yet procedures for distribution have yet to be standardized, making it difficult to track the types of goods that are shipped and their amounts. The aim of this study was to standardize the types and amounts of goods provided by medical facilities on the basis of the survey results. We conducted a survey of medical facilities and patients regarding the status of goods supplied for ISC. Data were collected from January to May 2010 from 5 outpatient urology clinics and 26 patients practicing ISC. The first finding of this research is that the amount of supplied goods was insufficient and part of the supply method was incorrect. The second is that the status of goods supplied changed not only with ISC, but also with hospital characteristics. The third is that hospital costs averaged $63·10; the supplied catheter number affected hospital costs. Patient costs per month averaged$26·50, clearly showing that patients experience an economic burden. Patient costs were high in cases in which the percentage of types of goods supplied was low. A researcher analysed survey data to determine issues and procedures relevant to the supply of goods. The study showed a need to develop an optimal supply system for ISC patients and identified issues in the current system in Japan that require resolution. © 2012 The Authors. International Journal of Urological Nursing © 2012 BAUN & Blackwell Publishing Ltd

Cancer Chemopreventive Ability of Conjugated Linolenic Acids

Conjugated fatty acids (CFA) have received increased interest because of their beneficial effects on human health, including preventing cancer development. Conjugated linoleic acids (CLA) are such CFA, and have been reviewed extensively for their multiple biological activities. In contrast to other types of CFAs including CLA that are found at low concentrations (less than 1%) in natural products, conjugated linolenic acids (CLN) are the only CFAs that occur in higher quantities in natural products. Some plant seeds contain a considerably high concentration of CLN (30 to 70 wt% lipid). Our research group has screened CLN from different plant seed oils to determine their cancer chemopreventive ability. This review describes the physiological functions of CLN isomers that occur in certain plant seeds. CLN are able to induce apoptosis through decrease of Bcl-2 protein in certain human cancer cell lines, increase expression of peroxisome proliferator-activated receptor (PPAR)-γ, and up-regulate gene expression of p53. Findings in our preclinical animal studies have indicated that feeding with CLN resulted in inhibition of colorectal tumorigenesis through modulation of apoptosis and expression of PPARγ and p53. In this review, we summarize chemopreventive efficacy of CLN against cancer development, especially colorectal cancer

ALMA CO Observations of a Giant Molecular Cloud in M33: Evidence for High-Mass Star Formation Triggered by Cloud-Cloud Collisions

We report the first evidence for high-mass star formation triggered by collisions of molecular clouds in M33. Using the Atacama Large Millimeter/submillimeter Array, we spatially resolved filamentary structures of giant molecular cloud 37 in M33 using $^{12}$CO($J$ = 2-1), $^{13}$CO($J$ = 2-1), and C$^{18}$O($J$ = 2-1) line emission at a spatial resolution of $\sim$2 pc. There are two individual molecular clouds with a systematic velocity difference of $\sim$6 km s$^{-1}$. Three continuum sources representing up to $\sim$10 high-mass stars with the spectral types of B0V-O7.5V are embedded within the densest parts of molecular clouds bright in the C$^{18}$O($J$ = 2-1) line emission. The two molecular clouds show a complementary spatial distribution with a spatial displacement of $\sim$6.2 pc, and show a V-shaped structure in the position-velocity diagram. These observational features traced by CO and its isotopes are consistent with those in high-mass star-forming regions created by cloud-cloud collisions in the Galactic and Magellanic Cloud HII regions. Our new finding in M33 indicates that the cloud-cloud collision is a promising process to trigger high-mass star formation in the Local Group.Comment: 13 pages, 10 figures, 1 table, accepted for publication in PAS

Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate

<p>Abstract</p> <p>Background</p> <p>Chronic inflammation is well known to be a risk factor for colon cancer. Previously we established a novel mouse model of inflammation-related colon carcinogenesis, which is useful to examine the involvement of inflammation in colon carcinogenesis. To shed light on the alterations in global gene expression in the background of inflammation-related colon cancer and gain further insights into the molecular mechanisms underlying inflammation-related colon carcinogenesis, we conducted a comprehensive DNA microarray analysis using our model.</p> <p>Methods</p> <p>Male ICR mice were given a single ip injection of azoxymethane (AOM, 10 mg/kg body weight), followed by the addition of 2% (w/v) dextran sodium sulfate (DSS) to their drinking water for 7 days, starting 1 week after the AOM injection. We performed DNA microarray analysis (Affymetrix GeneChip) on non-tumorous mucosa obtained from mice that received AOM/DSS, AOM alone, and DSS alone, and untreated mice at wks 5 and 10.</p> <p>Results</p> <p>Markedly up-regulated genes in the colonic mucosa given AOM/DSS at wk 5 or 10 included Wnt inhibitory factor 1 (<it>Wif1</it>, 48.5-fold increase at wk 5 and 5.7-fold increase at wk 10) and plasminogen activator, tissue (<it>Plat</it>, 48.5-fold increase at wk 5), myelocytomatosis oncogene (<it>Myc</it>, 3.0-fold increase at wk 5), and phospholipase A2, group IIA (platelets, synovial fluid) (<it>Plscr2</it>, 8.0-fold increase at wk 10). The notable down-regulated genes in the colonic mucosa of mice treated with AOM/DSS were the peroxisome proliferator activated receptor binding protein (<it>Pparbp</it>, 0.06-fold decrease at wk 10) and the transforming growth factor, beta 3 (<it>Tgfb3</it>, 0.14-fold decrease at wk 10). The inflammation-related gene, peroxisome proliferator activated receptor γ (<it>Pparγ </it>0.38-fold decrease at wk 5), was also down-regulated in the colonic mucosa of mice that received AOM/DSS.</p> <p>Conclusion</p> <p>This is the first report describing global gene expression analysis of an AOM/DSS-induced mouse colon carcinogenesis model, and our findings provide new insights into the mechanisms of inflammation-related colon carcinogenesis and the establishment of novel therapies and preventative strategies against carcinogenesis.</p