8 research outputs found
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Generation of PI3P in the normally PI3P-deficient ER membrane makes the organelle a platform for autophagosome formation
Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain
Rubicon, a subunit of the Beclin 1-PI3-kinase complex and its homologue, PLEKHM1, negatively regulate endocytic pathway through the interaction with Rab7. Synchronous association with the Beclin 1–PI3-kinase complex and Rab7 is necessary for the function of Rubicon, but not PLEKHM1