Effect of GBR12909 on affective behavior: Distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation

Rationale: It was recently demonstrated that the priming stimulation effect (PSE) in the runway model of intracranial self-stimulation (ICSS) can be used as a model system to study the motivational effects of drugs. However, the characteristics of this navel experimental model have not been fully clarified. Objective: To elucidate the involvement of dopamine uptake inhibition in motivated behavior and the difference in experimental characteristics between closely related experimental models, we investigated the effects of the dopamine uptake inhibitor GBR12909 in the runway ICSS model, in the forced swimming test (FST), and on conditioned place preference (CPP). In addition, the role of dopamine receptor signaling in the runway model was evaluated using dopamine receptor agonists and antagonists. Results: GBR12909 dose-dependently increased running speed on the runway and decreased immobility time in the FST without affecting the time spent in the drug-associated compartment in CPP tests. The effect of GBR12909 in the runway model was inhibited by pre-treatment with the dopamine receptor antagonists haloperidol and raclopride. The dopamine receptor agonists SKF38393 and quinpirole dose-dependently decreased running speed. Conclusions: These results demonstrate that GBR12909 displays motivation-enhancing and antidepressant-like effects without place conditioning effects. In addition, the mechanisms of PSE enhancement in the runway ICSS model are different from those underlying closely associated experimental models and are mediated by increases in dopamine signaling

Structural Studies on the Lipopolysaccharide of Aerobacter Aerogenes Strain Nctc 243

131 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1970.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Assessing the use of camera traps to measure reproductive success in Straw-necked Ibis breeding colonies

Nest monitoring may influence reproductive success and rates of predation. This study compared data from two methods of monitoring nests- repeated visits to nests by investigators and collection of data by camera traps-in Straw-necked Ibis Threskiornis spinicollis breeding colonies in the Murrumbidgee catchment in New South Wales. There was no significant difference in reproductive success between nests monitored by these two methods. These data show that (1) nest monitoring using camera traps is a valid survey method that reduces the need for investigators to engage in intensive and costly monitoring in the field, and (2) there was no detectable interference from repeated visits to nests by investigators on the reproductive success of ibis

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SIGLEBibliothek Weltwirtschaft Kiel C131,152 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman