Fabrication and in vitro characterization of polymeric nanoparticles for Parkinson's therapy: a novel approach

The objective of the research was to formulate and evaluate selegiline hydrochloride loaded chitosan nanoparticles for the Parkinson's therapy in order to improve its therapeutic effect and reducing dosing frequency. Taguchi method of design of experiments (L9 orthogonal array) was used to get optimized formulation. The selegiline hydrochloride loaded chitosan nanoparticles (SHPs) were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP) and tween 80 as surfactant. The SHPs had a mean size of (303.39 ± 2.01) nm, a zeta potential of +32.50mV, and entrapment efficiency of SHPs was 86.200 ± 1.38%. The in vitro drug release of SHPs was evaluated in phosphate buffer saline (pH 5.5) using goat nasal mucosa and found to be 82.529% ± 1.308 up to 28 h. Release kinetics studies showed that the release of drug from nanoparticles was anomalous (non-fickian) diffusion indicating the drug release is controlled by more than one process i.e. superposition of both phenomenon, the diffusion controlled as well as swelling controlled release. SHPs showed good stability results as found during stability studies at different temperatures as mentioned in ICH guidelines. The results revealed that selegiline hydrochloride loaded chitosan nanoparticles are most suitable mode of delivery of drug for promising therapeutic action

Evolution and validation of bioadhesion models predictive of retention in the oral cavity

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Baseline total organic carbon and calcium carbonate contents for sediment core SO268/1_67-1 (MUC-16) during RV SONNE cruise SO268/1 in the CCZ, Pacific Ocean

This baseline dataset comprises downcore measurements of total carbon (TC) and total organic carbon (TOC) for a sediment core (MUC) retrieved in the framework of the European collaborative JPI Oceans MiningImpact project onboard R/V SONNE cruise SO268 in 2019. The scientific work during cruise SO268 was part of the second phase of the MiningImpact project (Environmental impacts and risks of deep-sea mining) and is designed to assess the environmental impacts of deep-sea mining of polymetallic nodules in the Clarion-Clipperton Zone (CCZ) in the Pacific Ocean. The analysis was performed on freeze-dried, homogenized sediments using a CS744 LECO instrument (Bruker, Billerica, MA, USA) at the University of Bremen, Germany. In order to obtain TOC contents, samples were pre-treated with 3.4 M HCl and calcium carbonate (CaCO3) contents were calculated

Baseline total organic carbon and calcium carbonate contents for sediment core SO268/1_5-1 (MUC-01) during RV SONNE cruise SO268/1 in the CCZ, Pacific Ocean

This baseline dataset comprises downcore measurements of total carbon (TC) and total organic carbon (TOC) for a sediment core (MUC) retrieved in the framework of the European collaborative JPI Oceans MiningImpact project onboard R/V SONNE cruise SO268 in 2019. The scientific work during cruise SO268 was part of the second phase of the MiningImpact project (Environmental impacts and risks of deep-sea mining) and is designed to assess the environmental impacts of deep-sea mining of polymetallic nodules in the Clarion-Clipperton Zone (CCZ) in the Pacific Ocean. The analysis was performed on freeze-dried, homogenized sediments using a CS744 LECO instrument (Bruker, Billerica, MA, USA) at the University of Bremen, Germany. In order to obtain TOC contents, samples were pre-treated with 3.4 M HCl and calcium carbonate (CaCO3) contents were calculated

Baseline total organic carbon and calcium carbonate contents for sediment core SO268/1_79-1 (MUC-19) during RV SONNE cruise SO268/1 in the CCZ, Pacific Ocean

This baseline dataset comprises downcore measurements of total carbon (TC) and total organic carbon (TOC) for a sediment core (MUC) retrieved in the framework of the European collaborative JPI Oceans MiningImpact project onboard R/V SONNE cruise SO268 in 2019. The scientific work during cruise SO268 was part of the second phase of the MiningImpact project (Environmental impacts and risks of deep-sea mining) and is designed to assess the environmental impacts of deep-sea mining of polymetallic nodules in the Clarion-Clipperton Zone (CCZ) in the Pacific Ocean. The analysis was performed on freeze-dried, homogenized sediments using a CS744 LECO instrument (Bruker, Billerica, MA, USA) at the University of Bremen, Germany. In order to obtain TOC contents, samples were pre-treated with 3.4 M HCl and calcium carbonate (CaCO3) contents were calculated

Baseline total organic carbon and calcium carbonate contents for sediment core SO268/1_26-1 (MUC-06) during RV SONNE cruise SO268/1 in the CCZ, Pacific Ocean

This baseline dataset comprises downcore measurements of total carbon (TC) and total organic carbon (TOC) for a sediment core (MUC) retrieved in the framework of the European collaborative JPI Oceans MiningImpact project onboard R/V SONNE cruise SO268 in 2019. The scientific work during cruise SO268 was part of the second phase of the MiningImpact project (Environmental impacts and risks of deep-sea mining) and is designed to assess the environmental impacts of deep-sea mining of polymetallic nodules in the Clarion-Clipperton Zone (CCZ) in the Pacific Ocean. The analysis was performed on freeze-dried, homogenized sediments using a CS744 LECO instrument (Bruker, Billerica, MA, USA) at the University of Bremen, Germany. In order to obtain TOC contents, samples were pre-treated with 3.4 M HCl and calcium carbonate (CaCO3) contents were calculated

Baseline total organic carbon and calcium carbonate contents for sediment core SO268/1_19-1 (MUC-05) during RV SONNE cruise SO268/1 in the CCZ, Pacific Ocean

This baseline dataset comprises downcore measurements of total carbon (TC) and total organic carbon (TOC) for a sediment core (MUC) retrieved in the framework of the European collaborative JPI Oceans MiningImpact project onboard R/V SONNE cruise SO268 in 2019. The scientific work during cruise SO268 was part of the second phase of the MiningImpact project (Environmental impacts and risks of deep-sea mining) and is designed to assess the environmental impacts of deep-sea mining of polymetallic nodules in the Clarion-Clipperton Zone (CCZ) in the Pacific Ocean. The analysis was performed on freeze-dried, homogenized sediments using a CS744 LECO instrument (Bruker, Billerica, MA, USA) at the University of Bremen, Germany. In order to obtain TOC contents, samples were pre-treated with 3.4 M HCl and calcium carbonate (CaCO3) contents were calculated