Storytelling with UK Centenarians: Being a hundred - it’s just luck

What is it like to have lived one hundred years? In the opinion of those who are active and well, what has contributed to their longevity? If asked to tell a story about being 100 years old what would they talk about? In 2010 we interviewed 16 UK centenarians. We travelled to Scotland, Northern Ireland, Wales and England to interview participants in their own homes. We (Koch, Smith, Hutnik and Turner) asked centenarians to tell us their story. We heard about celebrating their 100th birthday with friends and family. We heard that there were 100 balloons or 100 roses or 100 reasons to continue partying into the future. Many chose to talk about aspects of their life that were foremost in their minds. Each person was given space to retell, using their own words, something about themselves and the social context that had shaped their lives. Interviews often included interested friends or relatives. Their accounts ran to several thousand words. Together these stories comprise a social history of ordinary lives lived during the 20th century and into the 21st. Let us introduce you to some of these remarkable older people

A Comparison of Male and Female Title I ADA Discrimination Allegations in Relation to Employer Characteristics

This investigation determined if there is a difference in the proportion of Title I workplace discrimination allegations filed by females in comparison to males under the Americans with Disabilities Act (ADA) in relation to the employer characteristics. Findings are reported and implications for future research and vocational rehabilitation practice

Long-term monitoring of the threatened lesser guineaflower Hibbertia calycina (DC.) N.A.Wakef. (Dilleniaceae) in Tasmania

This paper describes the distribution of the threatened shrub Hibbertia calycina (DC.) N.A.Wakef., a distinctive plant restricted to northeast Tasmania. It compares changes over time in population size and evaluates the species response to disturbance. Results found H. calycina distribution is restricted to isolated clumps on highly insolated ridges and steep upper slopes of fine-grained Mathinna-series sedimentary rocks in dry sclerophyll forest dominated by Eucalyptus sieberi L.Johnson. Nine populations were documented with an estimated area of occupancy of 0.43 km2 and area of extent measuring 95 km2, demonstrating that the current listing of H. calycina as vulnerable is appropriate on Tasmania’s Threatened Species Protection Act 1995. We believe that the distribution of the present population is a result of natural factors (i.e., restricted habitat range and natural fire events) and anthropogenic factors (managed fire regime and illegal firewood cutting). Although frequent fire and roading have the potential to impact populations, H. calycina appears to be stable without active management in a landscape of patchy, regular, low severity fire. Our results indicate susceptibility to the soil-borne pathogen Phytophthora cinnamomi is likely less problematic than previously postulated, yet more data and research is required before management is changed

Probing the quantum vacuum with an artificial atom in front of a mirror

Quantum fluctuations of the vacuum are both a surprising and fundamental phenomenon of nature. Understood as virtual photons flitting in and out of existence, they still have a very real impact, \emph{e.g.}, in the Casimir effects and the lifetimes of atoms. Engineering vacuum fluctuations is therefore becoming increasingly important to emerging technologies. Here, we shape vacuum fluctuations using a "mirror", creating regions in space where they are suppressed. As we then effectively move an artificial atom in and out of these regions, measuring the atomic lifetime tells us the strength of the fluctuations. The weakest fluctuation strength we observe is 0.02 quanta, a factor of 50 below what would be expected without the mirror, demonstrating that we can hide the atom from the vacuum

Classical kinetic energy, quantum fluctuation terms and kinetic-energy functionals

We employ a recently formulated dequantization procedure to obtain an exact expression for the kinetic energy which is applicable to all kinetic-energy functionals. We express the kinetic energy of an N-electron system as the sum of an N-electron classical kinetic energy and an N-electron purely quantum kinetic energy arising from the quantum fluctuations that turn the classical momentum into the quantum momentum. This leads to an interesting analogy with Nelson's stochastic approach to quantum mechanics, which we use to conceptually clarify the physical nature of part of the kinetic-energy functional in terms of statistical fluctuations and in direct correspondence with Fisher Information Theory. We show that the N-electron purely quantum kinetic energy can be written as the sum of the (one-electron) Weizsacker term and an (N-1)-electron kinetic correlation term. We further show that the Weizsacker term results from local fluctuations while the kinetic correlation term results from the nonlocal fluctuations. For one-electron orbitals (where kinetic correlation is neglected) we obtain an exact (albeit impractical) expression for the noninteracting kinetic energy as the sum of the classical kinetic energy and the Weizsacker term. The classical kinetic energy is seen to be explicitly dependent on the electron phase and this has implications for the development of accurate orbital-free kinetic-energy functionals. Also, there is a direct connection between the classical kinetic energy and the angular momentum and, across a row of the periodic table, the classical kinetic energy component of the noninteracting kinetic energy generally increases as Z increases.Comment: 10 pages, 1 figure. To appear in Theor Chem Ac

Geometric methods on low-rank matrix and tensor manifolds

In this chapter we present numerical methods for low-rank matrix and tensor problems that explicitly make use of the geometry of rank constrained matrix and tensor spaces. We focus on two types of problems: The first are optimization problems, like matrix and tensor completion, solving linear systems and eigenvalue problems. Such problems can be solved by numerical optimization for manifolds, called Riemannian optimization methods. We will explain the basic elements of differential geometry in order to apply such methods efficiently to rank constrained matrix and tensor spaces. The second type of problem is ordinary differential equations, defined on matrix and tensor spaces. We show how their solution can be approximated by the dynamical low-rank principle, and discuss several numerical integrators that rely in an essential way on geometric properties that are characteristic to sets of low rank matrices and tensors

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Storytelling reveals the active, positive lives of centenarians

Aim To present alternative stories of ageing that countered the prevailing negative stereotypes of older people by interviewing centenarians about their lives. Method Sixteen healthy UK centenarian volunteers were interviewed in their place of residence. A story draft was produced using the interview recording and verbatim transcript. The four researchers collaborated to generate a consensus storyline which was returned to the centenarian and their significant other for their corrections, additions, validation and consent to publish using their own names. Findings Centenarians elected to talk about living as independently as possible, their continuing growth and development and their ongoing close relationships. Difficulties and loss were considered to be ‘part of life’ indicated by comments such as: ‘accept whatever life brings’, ‘just plod on’, ‘do what you can to make things better and then move on’. Conclusion The centenarians present a positive picture of ageing, which counteracts negative stereotypes. Aspects of successful ageing relate to lifestyle and environment. Centenarians have felt ‘personalised’ through attention gained as part of the storytelling process, therefore older people may feel valued through listening and responding in this way