ECTOPIC OSSIFICATION FOLLOWING TOTAL HIP ARTHROPLASTY: IS DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS A RISK FACTOR?

Total hip a≪hroplasty may be followed by ectopic bone formation. An increased frequency has been suspected in patients with diffuse idiopathic skeletal hypcrostosis (DISH). In 204 patients we found that, of the 38 subjects with pre-existing DISH, 29% developed postoperative ossification compared with only 10% in those without DISH (p ≪; 0.01). DISH is therefore a risk factor for postoperative ectopic bone formation. In a separate study of 1325 patients (not analysed for spinal DISH), we looked for correlations between the severity of postoperative ectopic bone and clinical measurements. Even for the more severe ossification grades (n = 112), only 10% reported serious pain and only 26% had reduced hip flexion (≪70°). Thus, periprosthetic ectopic bone is not sufficiently important to justify the routine use of preventative drugs such as bisphosphonates in patients with DISH undergoing total hip replacemen

Random access quantum information processors

Qubit connectivity is an important property of a quantum processor, with an ideal processor having random access -- the ability of arbitrary qubit pairs to interact directly. Here, we implement a random access superconducting quantum information processor, demonstrating universal operations on a nine-bit quantum memory, with a single transmon serving as the central processor. The quantum memory uses the eigenmodes of a linear array of coupled superconducting resonators. The memory bits are superpositions of vacuum and single-photon states, controlled by a single superconducting transmon coupled to the edge of the array. We selectively stimulate single-photon vacuum Rabi oscillations between the transmon and individual eigenmodes through parametric flux modulation of the transmon frequency, producing sidebands resonant with the modes. Utilizing these oscillations for state transfer, we perform a universal set of single- and two-qubit gates between arbitrary pairs of modes, using only the charge and flux bias of the transmon. Further, we prepare multimode entangled Bell and GHZ states of arbitrary modes. The fast and flexible control, achieved with efficient use of cryogenic resources and control electronics, in a scalable architecture compatible with state-of-the-art quantum memories is promising for quantum computation and simulation.Comment: 7 pages, 5 figures, supplementary information ancillary file, 21 page

Solving Four Dimensional Field Theories with the Dirichlet Fivebrane

The realization of ${\cal N}=2$ four dimensional super Yang-Mills theories in terms of a single Dirichlet fivebrane in type IIB string theory is considered. A classical brane computation reproduces the full quantum low energy effective action. This result has a simple explanation in terms of mirror symmetry.Comment: Final version to appear in Phys. Rev.

Phonon-affected steady-state transport through molecular quantum dots

We consider transport through a vibrating molecular quantum dot contacted to macroscopic leads acting as charge reservoirs. In the equilibrium and nonequilibrium regime, we study the formation of a polaron-like transient state at the quantum dot for all ratios of the dot-lead coupling to the energy of the local phonon mode. We show that the polaronic renormalization of the dot-lead coupling is a possible mechanism for negative differential conductance. Moreover, the effective dot level follows one of the lead chemical potentials to enhance resonant transport, causing novel features in the inelastic tunneling signal. In the linear response regime, we investigate the impact of the electron-phonon interaction on the thermoelectrical properties of the quantum dot device.Comment: 11 pages, 7 figures, FQMT11 Proceeding

Single microtubules and small networks become significantly stiffer on short time-scales upon mechanical stimulation

The transfer of mechanical signals through cells is a complex phenomenon. To uncover a new mechanotransduction pathway, we study the frequency-dependent transport of mechanical stimuli by single microtubules and small networks in a bottom-up approach using optically trapped beads as anchor points. We interconnected microtubules to linear and triangular geometries to perform micro-rheology by defined oscillations of the beads relative to each other. We found a substantial stiffening of single filaments above a characteristic transition frequency of 1-30 Hz depending on the filament's molecular composition. Below this frequency, filament elasticity only depends on its contour and persistence length. Interestingly, this elastic behavior is transferable to small networks, where we found the surprising effect that linear two filament connections act as transistor-like, angle dependent momentum filters, whereas triangular networks act as stabilizing elements. These observations implicate that cells can tune mechanical signals by temporal and spatial filtering stronger and more flexibly than expected

A study of rotating globular clusters - the case of the old, metal-poor globular cluster NGC 4372

Aims: We present the first in-depth study of the kinematic properties and derive the structural parameters of NGC 4372 based on the fit of a Plummer profile and a rotating, physical model. We explore the link between internal rotation to different cluster properties and together with similar studies of more GCs, we put these in the context of globular cluster formation and evolution. Methods: We present radial velocities for 131 cluster member stars measured from high-resolution FLAMES/GIRAFFE observations. Their membership to the GC is additionally confirmed from precise metallicity estimates. Using this kinematic data set we build a velocity dispersion profile and a systemic rotation curve. Additionally, we obtain an elliptical number density profile of NGC 4372 based on optical images using a MCMC fitting algorithm. From this we derive the cluster's half-light radius and ellipticity as r_h=3.4'+/-0.04' and e=0.08+/-0.01. Finally, we give a physical interpretation of the observed morphological and kinematic properties of this GC by fitting an axisymmetric, differentially rotating, dynamical model. Results: Our results show that NGC 4372 has an unusually high ratio of rotation amplitude to velocity dispersion (1.2 vs. 4.5 km/s) for its metallicity. This, however, puts it in line with two other exceptional, very metal-poor GCs - M 15 and NGC 4590. We also find a mild flattening of NGC 4372 in the direction of its rotation. Given its old age, this suggests that the flattening is indeed caused by the systemic rotation rather than tidal interactions with the Galaxy. Additionally, we estimate the dynamical mass of the GC M_dyn=2.0+/-0.5 x 10^5 M_Sun based on the dynamical model, which constrains the mass-to-light ratio of NGC 4372 between 1.4 and 2.3 M_Sun/L_Sun, representative of an old, purely stellar population.Comment: Accepted for publication in A&A, 12 pages, 14 figures, 2 table

Non-Universal Behavior of Finite Quantum Hall Systems as a Result of Weak Macroscopic Inhomogeneities

We show that, at low temperatures, macroscopic inhomogeneities of the electron density in the interior of a finite sample cause a reduction in the measured conductivity peak heights $\sigma_{xx}^{\rm max}$ compared to the universal values previously predicted for infinite homogeneous samples. This effect is expected to occur for the conductivity peaks measured in standard experimental geometries such as the Hall bar and the Corbino disc. At the lowest temperatures, the decrease in $\sigma_{xx}^{\rm max}(T)$ is found to saturate at values proportional to the difference between the adjacent plateaus in $\sigma_{xy}$, with a prefactor which depends on the particular realization of disorder in the sample. We argue that this provides a possible explanation of the ``non-universal scaling'' of $\sigma_{xx}^{\rm max}$ observed in a number of experiments. We also predict an enhancement of the ``non-local'' resistance due to the macroscopic inhomogeneities. We argue that, in the Hall bar with a sharp edge, the enhanced ``non-local'' resistance and the size corrections to the ``local'' resistance $R_{xx}$ are directly related. Using this relation, we suggest a method by which the finite-size corrections may be eliminated from $R_{xx}$ and $R_{xy}$ in this case.Comment: REVTEX 3.0 file (38 pages) + 5 postscript figures in uuencoded format. Revised version includes an additional figure showing unpublished experimental dat

A Heterosynaptic Learning Rule for Neural Networks

In this article we intoduce a novel stochastic Hebb-like learning rule for neural networks that is neurobiologically motivated. This learning rule combines features of unsupervised (Hebbian) and supervised (reinforcement) learning and is stochastic with respect to the selection of the time points when a synapse is modified. Moreover, the learning rule does not only affect the synapse between pre- and postsynaptic neuron, which is called homosynaptic plasticity, but effects also further remote synapses of the pre- and postsynaptic neuron. This more complex form of synaptic plasticity has recently come under investigations in neurobiology and is called heterosynaptic plasticity. We demonstrate that this learning rule is useful in training neural networks by learning parity functions including the exclusive-or (XOR) mapping in a multilayer feed-forward network. We find, that our stochastic learning rule works well, even in the presence of noise. Importantly, the mean learning time increases with the number of patterns to be learned polynomially, indicating efficient learning.Comment: 19 page