3,860 research outputs found
Efficient one- and two-qubit pulsed gates for an oscillator stabilized Josephson qubit
We present theoretical schemes for performing high-fidelity one- and
two-qubit pulsed gates for a superconducting flux qubit. The "IBM qubit"
consists of three Josephson junctions, three loops, and a superconducting
transmission line. Assuming a fixed inductive qubit-qubit coupling, we show
that the effective qubit-qubit interaction is tunable by changing the applied
fluxes, and can be made negligible, allowing one to perform high fidelity
single qubit gates. Our schemes are tailored to alleviate errors due to 1/f
noise; we find gates with only 1% loss of fidelity due to this source, for
pulse times in the range of 20-30ns for one-qubit gates (Z rotations,
Hadamard), and 60ns for a two-qubit gate (controlled-Z). Our relaxation and
dephasing time estimates indicate a comparable loss of fidelity from this
source. The control of leakage plays an important role in the design of our
shaped pulses, preventing shorter pulse times. However, we have found that
imprecision in the control of the quantum phase plays the major role in the
limitation of the fidelity of our gates.Comment: Published version. Added references. Corrected minor typos. Added
discussion on how the influence of 1/f noise is modeled. 36 pages, 11 figure
Giant Gravitons - with Strings Attached (III)
We develop techniques to compute the one-loop anomalous dimensions of
operators in the super Yang-Mills theory that are dual to open
strings ending on boundstates of sphere giant gravitons. Our results, which are
applicable to excitations involving an arbitrary number of open strings,
generalize the single string results of hep-th/0701067. The open strings we
consider carry angular momentum on an S embedded in the S of the
AdSS background. The problem of computing the one loop anomalous
dimensions is replaced with the problem of diagonalizing an interacting Cuntz
oscillator Hamiltonian. Our Cuntz oscillator dynamics illustrates how the
Chan-Paton factors for open strings propagating on multiple branes can arise
dynamically.Comment: 66 pages; v2: improved presentatio
Constant Size Molecular Descriptors For Use With Machine Learning
A set of molecular descriptors whose length is independent of molecular size
is developed for machine learning models that target thermodynamic and
electronic properties of molecules. These features are evaluated by monitoring
performance of kernel ridge regression models on well-studied data sets of
small organic molecules. The features include connectivity counts, which
require only the bonding pattern of the molecule, and encoded distances, which
summarize distances between both bonded and non-bonded atoms and so require the
full molecular geometry. In addition to having constant size, these features
summarize information regarding the local environment of atoms and bonds, such
that models can take advantage of similarities resulting from the presence of
similar chemical fragments across molecules. Combining these two types of
features leads to models whose performance is comparable to or better than the
current state of the art. The features introduced here have the advantage of
leading to models that may be trained on smaller molecules and then used
successfully on larger molecules.Comment: 18 pages, 5 figure
Chemical Abundances of the Leo II Dwarf Galaxy
We use previously-published moderate-resolution spectra in combination with
stellar atmosphere models to derive the first measured chemical abundance
ratios in the Leo II dSph galaxy. We find that for spectra with SNR > 24, we
are able to measure abundances from weak Ti, Fe and Mg lines located near the
calcium infrared triplet (CaT). We also quantify and discuss discrepancies
between the metallicities measured from Fe I lines and those estimated from the
CaT features. We find that while the most metal-poor ([Fe/H] <-2.0]) Leo II
stars have Ca and Ti abundance ratios similar to those of Galactic globular
clusters, the more metal-rich stars show a gradual decline of Ti, Mg and Ca
abundance ratio with increasing metallicity. Finding these trends in this
distant and apparently dynamically stable dSph galaxy supports the hypothesis
that the slow chemical enrichment histories of the dSph galaxies is universal,
independent of any interaction with the Milky Way. Combining our spectroscopic
abundances with published broadband photometry and updated isochrones, we are
able to approximate stellar ages for our bright RGB stars to a relative
precision of 2-3 Gyr. While the derived age-metallicity relationship of Leo II
hints at some amount of slow enrichment, the data are still statistically
consistent with no enrichment over the history of Leo II.Comment: Accepted to A
Estrogen-Like Activity of Perfluoroalkyl Acids In Vivo and Interaction with Human and Rainbow Trout Estrogen Receptors In Vitro
The objectives of this study were to determine the structural characteristics of perfluoroalkyl acids (PFAAs) that confer estrogen-like activity in vivo using juvenile rainbow trout (Oncorhynchus mykiss) as an animal model and to determine whether these chemicals interact directly with the estrogen receptor (ER) using in vitro and in silico species comparison approaches. Perfluorooctanoic (PFOA), perfluorononanoic (PFNA), perfluorodecanoic (PFDA), and perfluoroundecanoic (PFUnDA) acids were all potent inducers of the estrogen-responsive biomarker protein vitellogenin (Vtg) in vivo, although at fairly high dietary exposures. A structure-activity relationship for PFAAs was observed, where eight to ten fluorinated carbons and a carboxylic acid end group were optimal for maximal Vtg induction. These in vivo findings were corroborated by in vitro mechanistic assays for trout and human ER. All PFAAs tested weakly bound to trout liver ER with half maximal inhibitory concentration (IC50) values of 15.2-289μM. Additionally, PFOA, PFNA, PFDA, PFUnDA, and perlfuorooctane sulfonate (PFOS) significantly enhanced human ERα-dependent transcriptional activation at concentrations ranging from 10-1000nM. Finally, we employed an in silico computational model based upon the crystal structure for the human ERα ligand-binding domain complexed with E2 to structurally investigate binding of these putative ligands to human, mouse, and trout ERα. PFOA, PFNA, PFDA, and PFOS all efficiently docked with ERα from different species and formed a hydrogen bond at residue Arg394/398/407 (human/mouse/trout) in a manner similar to the environmental estrogens bisphenol A and nonylphenol. Overall, these data support the contention that several PFAAs are weak environmental xenoestrogens of potential concer
Acute Chloroform Ingestion Successfully Treated with Intravenously Administered N-acetylcysteine
Chloroform, a halogenated hydrocarbon, causes central nervous system depression, cardiac arrhythmias, and hepatotoxicity. We describe a case of chloroform ingestion with a confirmatory serum level and resultant hepatotoxicity successfully treated with intravenously administered N-acetylcysteine (NAC). A 19-year-old man attempting suicide ingested approximately 75 mL of chloroform. He was unresponsive and intubated upon arrival. Intravenously administered NAC was started after initial stabilization was complete. His vital signs were normal. Admission laboratory values revealed normal serum electrolytes, AST, ALT, PT, BUN, creatinine, and bilirubin. Serum ethanol level was 15 mg/dL, and aspirin and acetaminophen were undetectable. The patient was extubated but developed liver function abnormalities with a peak AST of 224 IU/L, ALT of 583 IU/L, and bilirubin level reaching 16.3 mg/dL. NAC was continued through hospital day 6. Serum chloroform level obtained on admission was 91 μg/mL. The patient was discharged to psychiatry without known sequelae and normal liver function tests. The average serum chloroform level in fatal cases of inhalational chloroform poisoning was 64 μg/mL, significantly lower than our patient. The toxicity is believed to be similar in both inhalation and ingestion routes of exposure, with mortality predominantly resulting from anoxia secondary to central nervous system depression. Hepatocellular toxicity is thought to result from free radical-induced oxidative damage. Previous reports describe survival after treatment with orally administered NAC, we report the first use of intravenously administered NAC for chloroform ingestion. Acute oral ingestion of chloroform is extremely rare. Our case illustrates that with appropriate supportive care, patients can recover from chloroform ingestion, and intravenously administered NAC may be of benefit in such cases
The Kepler Follow-up Observation Program
The Kepler Mission was launched on March 6, 2009 to perform a photometric
survey of more than 100,000 dwarf stars to search for terrestrial-size planets
with the transit technique. Follow-up observations of planetary candidates
identified by detection of transit-like events are needed both for
identification of astrophysical phenomena that mimic planetary transits and for
characterization of the true planets and planetary systems found by Kepler. We
have developed techniques and protocols for detection of false planetary
transits and are currently conducting observations on 177 Kepler targets that
have been selected for follow-up. A preliminary estimate indicates that between
24% and 62% of planetary candidates selected for follow-up will turn out to be
true planets.Comment: 12 pages, submitted to the Astrophysical Journal Letter
Recommended from our members
Kepler-4B: A Hot Neptune-Like Planet of A G0 Star Near Main-Sequence Turnoff
Early time-series photometry from NASA's Kepler spacecraft has revealed a planet transiting the star we term Kepler-4, at R.A. = 19(h)02(m)27.(s)68, delta = +50 degrees 08'08 '' 7. The planet has an orbital period of 3.213 days and shows transits with a relative depth of 0.87 x 10(-3) and a duration of about 3.95 hr. Radial velocity (RV) measurements from the Keck High Resolution Echelle Spectrometer show a reflex Doppler signal of 9.3(-1.9)(+1.1) m s(-1), consistent with a low-eccentricity orbit with the phase expected from the transits. Various tests show no evidence for any companion star near enough to affect the light curve or the RVs for this system. From a transit-based estimate of the host star's mean density, combined with analysis of high-resolution spectra, we infer that the host star is near turnoff from the main sequence, with estimated mass and radius of 1.223(-0.091)(+0.053) M(circle dot) and 1.487(-0.084)(+0.071) R(circle dot).We estimate the planet mass and radius to be {M(P), R(P)} = {24.5 +/- 3.8 M(circle plus), 3.99 +/- 0.21 R(circle plus)}. The planet's density is near 1.9 g cm(-3); it is thus slightly denser and more massive than Neptune, but about the same size.W. M. Keck FoundationNASA's Science Mission DirectorateAstronom
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