Association of polycystic ovary syndrome and a non-dipping blood pressure pattern in young women

OBJECTIVE: The association between polycystic ovarian syndrome and increased cardiovascular disease risk is still a controversial issue. In light of data documenting some common pathways or common end-points, the present study was undertaken to determine whether there is a relationship between sleep blood pressure pattern disturbances and polycystic ovarian syndrome in young women. METHOD: The daytime and nighttime ambulatory blood pressures (BPs) were determined for each subject, according to the actual waking and sleeping times recorded in their individual diaries, in this cross-sectional study. RESULTS: The study group comprised 168 women (mean age: 25.7±5.5) diagnosed with polycystic ovarian syndrome, while the control group included 52 age- and BMI-matched healthy subjects (mean age: 26.1±5.4). When nocturnal BP declines very little or not at all, with the BP falling less than 10% during sleep compared with waking values, this pattern is classified as a non-dipping BP pattern. However, the non-dipping pattern of BP changes was significantly more common in polycystic ovarian syndrome patients compared to the control group (p<0.01). The prevalence of a non-dipping BP pattern was 43.4% (73 patients) in polycystic ovarian syndrome patients and 3.9% (2 patients) in the control group. CONCLUSION: Our cross-sectional study revealed that a non-dipping BP pattern is highly prevalent in polycystic ovarian syndrome patients, even if they are young and non-obese

Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 mu mol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNFalpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis

Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome

Objective: To determine 24-hour ambulatory blood pressures (ABP) in patients with polycystic ovary syndrome (PCOS) and its relationship with interleukin-6 (IL-6). Design: Prospective controlled study. Setting: University hospital. Patient(s): Fifty-four PCOS patients. Intervention(s): Ambulatory blood pressure monitoring was conducted. Anthropometric, hormonal, metabolic, and inflammatory parameters, including plasma IL-6, C-reactive protein (CRP), fibrinogen, and nitric oxide (NO), were measured in each subject. Main Outcome Measure(s): Ambulatory blood pressure and plasma IL-6, CRP, fibrinogen, and NO. Result(s): Serum IL-6 levels of PCOS women in the highest systolic blood pressure (SBP) quartile were significantly higher than those of women in the lowest SBP quartile. The high serum IL-6 levels (serum IL-6 level R5.1 pg/mL) were associated with a higher probability of raised SBP (R126 mm Hg), with an odds ratio of 2.2 (95% confidence interval 0.8–7.9). The systolic and diastolic (DBP) blood pressures were significantly related to serum IL-6 levels. The IL-6 levels were positively and significantly correlated with serum CRP levels. Interleukin- 6 and CRP were negatively and significantly correlated with serum NO levels. Conlusion(s): The results suggest that raised plasma IL-6 levels may be related to ambulatory SBP and DBP in PCOS

Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis

Linkage disequilibrium mapping of a breast cancer susceptibility locus near RAI/PPPIRI3L/iASPP

Background: Previous results have suggested an association of the region of 19q13.3 with several forms of cancer. In the present study, we investigated 27 public markers within a previously identified 69 kb stretch of chromosome 19q for association with breast cancer by using linkage disequilibrium mapping. The study groups included 434 postmenopausal breast cancer cases and an identical number of individually matched controls. Methods and Results: Studying one marker at a time, we found a region spanning the gene RAI ( alias PPP1R13L or iASPP) and the 5' portion of XPD to be associated with this cancer. The region corresponds to a haplotype block, in which there seems to be very limited recombination in the Danish population. Studying combinations of markers, we found that two to four neighboring markers gave the most consistent and strongest result. The haplotypes with strongest association with cancers were located in the gene RAI and just 3' to the gene. Coinciding peaks were seen in the region of RAI in groups of women of different age. In a follow-up to these results we sequenced 10 cases and 10 controls in a 44 kb region spanning the peaks of association. This revealed 106 polymorphisms, many of which were not in the public databases. We tested an additional 44 of these for association with disease and found a new tandem repeat marker, called RAI-3' d1, located downstream of the transcribed region of RAI, which was more strongly associated with breast cancer than any other marker we have tested (RR = 2.44 (1.41 - 4.23, p = 0.0008, all cases; RR = 6.29 (1.49 - 26.6), p = 0.01, cases up to 55 years of age). Conclusion: We expect the marker RAI-3' d1 to be (part of) the cause for the association of the chromosome 19q13.3 region's association with cancer

Giresun sakinlerinin rekreasyon talepleri, kent içi ve yakın çevresindeki ekoturizm kaynaklarının rekreasyon potansiyellerinin belirlenmesi

Sanayi devrimi sonucunda meydana gelen aşırı endüstrileşme, kentleşme ve doğal hayattan uzaklaşma ekolojik dengede sıkıntılar meydana getirmiştir. İnsan gücüne dayalı iş kaynaklarının toplumda meydana getirdiği stres ve yorgunluk hali önceden de var olan rekreasyon etkinliklerine katılımı arttırmış ve ihtiyaç haline getirmiştir. Bunun en yakın örneğini ise 2020 yılında tüm dünyayı çepe çevre saran Covid-19 virüsü salgınında evlere kapandıkça yaşadığımız sıkıntılarla görmekteyiz. Rekreasyonun günlük yaşamımızda bu denli önemli olması, bu rekreasyon faaliyetlerinin alanlarda çeşitlendirilmesini gerektirmektedir. Bu nedenle rekreasyona uygun açık alanların potansiyellerini ve bu potansiyelin kapasitesi ile sağlanacak performans değerlerinin de bilinmesi gerekmektedir. Bu çalışma Doğu Karadeniz bölgemizin yaylaları ve vejetaryen mutfağı ile meşhur Giresun İlinde yapılmıştır. Çünkü, Giresun küresel iklim değişimine bağlı olarak sayılarının azalacağı öngörülen yaşanılabilir coğrafya içerisinde gösterilen illerimizden birisidir. Giresun doğası her mevsim sunduğu değişen rekreasyon ve turizm aktivite çeşitliliği ile geleceğin önemli destinasyonlarından biri olarak gösterilmektedir. Bu özelliğini büyük ölçüde doğasına borçludur ve Giresun doğası mutlak surette sürdürülebilir turizm anlayışıyla turistlik hareketliliğin içine alınmalıdır. Doğayı koruyarak kullanmamız için yapmamız gereken olmazsa olmaz çalışmalardan birisi rekreasyon potansiyelinin tespit edilmesidir. Rekreasyon potansiyeli tespitinde, ülkemizde neredeyse kullanılan tek yöntem Gülez yöntemidir. Bu yönüyle bizde çalışmamızda temel ölçek olarak Gülez yöntemini kullanmayı tercih ettik. Giresun şehrinde, halkın en çok tercih ettiği kent içi rekreasyon alanlarından olan ve bugüne kadar rekreasyon potansiyelleri çalışılmamış Giresun Kalesi, Giresun Adası ve Giresun Gedikkaya rekreasyon alanı çalışılmak üzere belirlenmiştir. Seçilen bu alanlarda 390 katılımcı ile rekreasyonel taleplerini belirlemek için yüz yüze anket çalışması gerçekleştirilmiştir. Bu anket verileri güvenirlik analizleri yapıldıktan sonra temel istatistik işlemlerle “rekreasyon alanı kapasite ve performans analizi” hazırlığında kullanılmıştır. Alanların rekreasyon potansiyeli, kapasitesi ve performans değerleri sırasıyla, Giresun Kalesi için bulunan; % 73, % 85, % 50 Giresun Adası için, ‘ % 61, % 46, % 8, ve Gedikkaya için, %63, %72, %19, olarak hesaplanmıştır