CNN-based deep learning method for predicting the disease response to the Neoadjuvant Chemotherapy (NAC) treatment in breast cancer

Objective: The objective of the study is to evaluate the performance of CNN-based proposed models for predicting patients' response to NAC treatment and the disease development process in the pathological area. The study aims to determine the main criteria that affect the model's success during training, such as the number of convolutional layers, dataset quality and depended variable. Method: The study uses pathological data frequently used in the healthcare industry to evaluate the proposed CNN-based models. The researchers analyze the classification performances of the models and evaluate their success during training. Results: The study shows that using deep learning methods, particularly CNN models, can offer strong feature representation and lead to accurate predictions of patients' response to NAC treatment and the disease development process in the pathological area. A model that predicts ‘miller coefficient’, ‘tumor lymph node value’, ‘complete response in both tumor and axilla’ values with high accuracy, which is considered to be effective in achieving complete response to treatment, has been created. Estimation performance metrics have been obtained as 87%, 77% and 91%, respectively. Conclusion: The study concludes that interpreting pathological test results with deep learning methods is an effective way of determining the correct diagnosis and treatment method, as well as the prognosis follow-up of the patient. It provides clinicians with a solution to a large extent, particularly in the case of large, heterogeneous datasets that can be challenging to manage with traditional methods. The study suggests that using machine learning and deep learning methods can significantly improve the performance of interpreting and managing healthcare data

Comparison of two procedures for symptomatic hemorrhoidal disease: Ligation under Vision and Ferguson Hemorrhoidectomy - A retrospective cohort study

Conclusions: LUV is a safe, and practical procedure with similar outcomes compared to FH. LUV may be a better choice than excisional hemorrhoidectomies when three or four quadrants of the anal canal are involved with hemorrhoids as this reduces mucosal defect related possible complications such as ectropion and anal stenosis

Littoral cell angioma of the spleen: case report and literature review

Conclusions Long-term follow-up for suspicious malignant potential is advised

A practical scoring system to predict mortality in patients with perforated peptic ulcer

Conclusion: Because the new system consists only age and routinely measured two simple laboratory tests (albumin and BUN), its application is easy and prediction power is satisfactory. Verification of this new scoring system is required by large scale multicenter studies

Pancreatic schwannoma: A rare case and a brief literature review

Introduction: Pancreatic schwannoma (PS) is an extremly rare benign tumor. Less than 50 cases of pancreatic schwannoma have been described in the English literature over the past thirty years. Presentation of case report: A 63-year-old female underwent left modified radical mastectomy 2 years ago due to breast cancer. During her routine check-up, a 65 × 63 × 55 mm measured calcified, well-demarcated, cystic-mass having septations and calcifications that localized to the pancreatic head was detected by abdominal computerized tomography. She was asymptomatic and her tumor markers were in normal ranges. A standard Whipple procedure was performed, and the histo-pathological diagnosis of the resected specimen was reported as ancient schwannoma with clear surgical margins. Patient’s postoperative course was eventful. She had a biliary leakage after surgery which was managed conservatively. She is under follow-up. Discussion: Pancreatic schwannoma also known as neurilemoma or neuroma is a slowly growing, encapsulated, mostly benign tumor with smooth well-delineated margins that originates from myelin producing schwann cells located on the nerve sheath of the peripheral epineurium of either the sympathetic or parasympathetic autonomic fibers. PS’s are extremly rare. The head of pancreas being involved in the vast majority of cases (40%), followed by its body (20%). Management of pancreatic schwannomas remains largely controversial. Both enucleation and radical surgical resections have revealed great therapeutic efficiency. with a well prognosis without recurrences. Conclusion: Although rare, PS’s should be considered in the differential diagnosis of the other solid or cystic masses of the pancreas