A transformation of business process models into software-executable models using MDA

Traditional software development projects for process-oriented organizations are time consuming and do not always guarantee the fulfillment of the functional requirements of the client organization, and thus the quality of the resulting software product. To reduce the time spent for developing software and improve its quality, we adopt the inclusion of automation in some parts of the software development process. Thus, in this paper, we propose a model transformation approach to derive an executable model for the business processes of a given organization. We execute a mapping between processes (described with a business process execution language) and software components. We also propose a supporting software architecture based on an Enterprise Service Bus and on Java Business Integration, and we use an already defined methodology to execute the model transformation project.FEDER, FC

Early socialization and environmental enrichment of lactating piglets affects the caecal microbiota and metabolomic response after weaning

The aim of this study was to determine the possible impact of early socialization and an enriched neonatal environment to improve adaptation of piglets to weaning. We hypothesized that changes in the microbiota colonization process and in their metabolic response and intestinal functionality could help the animals face weaning stress. A total of 48 sows and their litters were allotted into a control (CTR) or an enriched treatment (ENR), in which piglets from two adjacent pens were combined and enriched with toys. The pattern of caecal microbial colonization, the jejunal gene expression, the serum metabolome and the intestinal physiology of the piglets were assessed before (-2 d) and after weaning (+ 3d). A differential ordination of caecal microbiota was observed after weaning. Serum metabolome suggested a reduced energetic metabolism in ENR animals, as evidenced by shifts in triglycerides and fatty acids, VLDL/LDL and creatine regions. The TLR2 gene showed to be downregulated in the jejunum of ENR pigs after weaning. The integration of gene expression, metabolome and microbiota datasets confirmed that differences between barren and enriched neonatal environments were evident only after weaning. Our results suggest that improvements in adaptation to weaning could be mediated by a better response to the post-weaning stress.info:eu-repo/semantics/publishedVersio

CP--violating Chargino Contributions to the Higgs Coupling to Photon Pairs in the Decoupling Regime of Higgs Sector

In most supersymmetric theories, charginos $\tilde{\chi}^\pm_{1,2}$ belong to the class of the lightest supersymmetric particles and the couplings of Higgs bosons to charginos are in general complex so that the CP--violating chargino contributions to the loop--induced coupling of the lightest Higgs boson to photon pairs can be sizable even in the decoupling limit of large pseudoscalar mass $m_A$ with only the lightest Higgs boson kinematically accessible at future high energy colliders. We introduce a specific benchmark scenario of CP violation consistent with the electric dipole moment constraints and with a commonly accepted baryogenesis mechanism in the minimal supersymmetric Standard Model. Based on the benchmark scenario of CP violation, we demonstrate that the fusion of the lightest Higgs boson in linearly polarized photon--photon collisions can allow us to confirm the existence of the CP--violating chargino contributions {\it even in the decoupling regime of the Higgs sector} for nearly degenerate SU(2) gaugino and higgsino mass parameters of about the electroweak scale.Comment: 1+13 pages, 3 eps figure

MSSM Higgs sector CP violation at photon colliders: Revisited

We present a comprehensive analysis on the MSSM Higgs sector CP violation at photon colliders including the chargino contributions as well as the contributions of other charged particles. The chargino loop contributions can be important for the would-be CP odd Higgs production at photon colliders. Polarization asymmetries are indispensable in determining the CP properties of neutral Higgs bosons.Comment: 24 pages, 40 figure

Reducing overuse of cervical cancer screening: A systematic review

Overuse of clinical preventive services increases healthcare costs and may deprive underserved patients of necessary care. Up to 45% of cervical cancer screening is overuse. We conducted a systematic review of correlates of overuse of cervical cancer screening and interventions to reduce overuse. The search identified 25 studies (20 observational; 5 intervention). Correlates varied by the type of overuse measured (i.e., too frequent, before/after recommended age to start or stop screening, after hysterectomy), the most common correlates of overuse related to patient age (n = 7), OBGYN practice or provider (n = 5), location (n = 4), and marital status (n = 4). Six observational studies reported a decrease in overuse over time. Screening overuse decreased in all intervention studies, which used before-after designs with no control or comparison groups. Observational studies suggest potential targets for de-escalating overuse. Randomized clinical trials are needed to establish best practices for reducing overuse

Strong Couplings of Heavy Mesons to A Light Vector Meson in QCD

We make a detailed analysis of the $BB\rho(DD\rho)$ and $B^*B\rho(D^{*}D\rho)$ strong couplings $g_{BB\rho}(g_{DD\rho})$ and $g_{B^*B\rho}(g_{D^{*}D\rho})$ using QCD light cone sum rules(LCSR). The existing some negligence is pointed out in the previous LCSR calculation on $g_{B^*B\rho} (g_{D^{\ast}D\rho}$) and an updated estimate is presented. Our findings can be used to understand the behavior of the $B,D \to \rho$ semileptonic form factors at large momentum transitions.Comment: 15 pages, latex, 2 figures, version appearing in PRD, typos correcte

Simulations of the Static Friction Due to Adsorbed Molecules

The static friction between crystalline surfaces separated by a molecularly thin layer of adsorbed molecules is calculated using molecular dynamics simulations. These molecules naturally lead to a finite static friction that is consistent with macroscopic friction laws. Crystalline alignment, sliding direction, and the number of adsorbed molecules are not controlled in most experiments and are shown to have little effect on the friction. Temperature, molecular geometry and interaction potentials can have larger effects on friction. The observed trends in friction can be understood in terms of a simple hard sphere model.Comment: 13 pages, 13 figure

Search for Λc+→pK+π−\Lambda_c^+ \to p K^+ \pi^- and Ds+→K+K+π−D_s^+ \to K^+ K^+ \pi^- Using Genetic Programming Event Selection

We apply a genetic programming technique to search for the double Cabibbo suppressed decays $\Lambda_c^+ \to p K^+ \pi^-$ and $D_s^+ \to K^+ K^+ \pi^-$. We normalize these decays to their Cabibbo favored partners and find $\text{BR}($\Lambda_c^+ \to p K^+ \pi^-$)/\text{BR}($\Lambda_c^+ \to p K^- \pi^+$) = (0.05 \pm 0.26 \pm 0.02)$ and $\text{BR}($D_s^+ \to K^+ K^+ \pi^-$)/\text{BR}($D_s^+ \to K^+ K^- \pi^+$) = (0.52\pm 0.17\pm 0.11)$ where the first errors are statistical and the second are systematic. Expressed as 90% confidence levels (CL), we find $< 0.46$ and $< 0.78$ respectively. This is the first successful use of genetic programming in a high energy physics data analysis.Comment: 10 page

Coronary Atherosclerosis Phenotypes in Focal and Diffuse Disease.

The interplay between coronary hemodynamics and plaque characteristics remains poorly understood. The aim of this study was to compare atherosclerotic plaque phenotypes between focal and diffuse coronary artery disease (CAD) defined by coronary hemodynamics. This multicenter, prospective, single-arm study was conducted in 5 countries. Patients with functionally significant lesions based on an invasive fractional flow reserve ≤0.80 were included. Plaque analysis was performed by using coronary computed tomography angiography and optical coherence tomography. CAD patterns were assessed using motorized fractional flow reserve pullbacks and quantified by pullback pressure gradient (PPG). Focal and diffuse CAD was defined according to the median PPG value. A total of 117 patients (120 vessels) were included. The median PPG was 0.66 (IQR: 0.54-0.75). According to coronary computed tomography angiography analysis, plaque burden was higher in patients with focal CAD (87% ± 8% focal vs 82% ± 10% diffuse; P = 0.003). Calcifications were significantly more prevalent in patients with diffuse CAD (Agatston score per vessel: 51 [IQR: 11-204] focal vs 158 [IQR: 52-341] diffuse; P = 0.024). According to optical coherence tomography analysis, patients with focal CAD had a significantly higher prevalence of circumferential lipid-rich plaque (37% focal vs 4% diffuse; P = 0.001) and thin-cap fibroatheroma (TCFA) (47% focal vs 10% diffuse; P = 0.002). Focal disease defined by PPG predicted the presence of TCFA with an area under the curve of 0.73 (95% CI: 0.58-0.87). Atherosclerotic plaque phenotypes associate with intracoronary hemodynamics. Focal CAD had a higher plaque burden and was predominantly lipid-rich with a high prevalence of TCFA, whereas calcifications were more prevalent in diffuse CAD. (Precise Percutaneous Coronary Intervention Plan [P3]; NCT03782688)