The impact of digital therapeutics on the pharmaceutical industry in the treatment of mental health disorders

Digital alternatives to traditional treatment methods for mental health disorders are increasing. These digital therapeutics pose a threat to the traditional pharmaceutical company, having the ability to potentially replace some medications in the treatment. While the digital therapeutics sector is growing, the economic implications of the technology for pharmaceutical companies is rarely discussed in academic literature. This dissertation aims to close the knowledge gap by providing ex-ante predictions of the disruption potential of digital therapeutics in the treatment of mental health disorders. A mixed research approach consisting of both expert interviews and a survey was used to collect market insights from both digital therapeutic and pharmaceutical industries. In combination with knowledge gathered from current literature, predictions about the disruption potential of digital therapeutics in the mental health care market were made. The findings indicated a high disruption potential for digital therapeutics within the mental health care market. A complete displacement of pharmaceuticals is unlikely. For future research, additional medical specialties or competitive capabilities of pharmaceutical companies can be examined as the market environment constantly changes.As alternativas digitais aos métodos tradicionais de tratamento das perturbações da saúde mental estão a aumentar. Estas terapêuticas digitais representam uma ameaça para a empresa farmacêutica tradicional, tendo a capacidade de potencialmente substituir alguns medicamentos no tratamento. Enquanto o sector da terapêutica digital está a crescer, o tema é raramente discutido na literatura académica sobre as implicações económicas da tecnologia para as empresas farmacêuticas. Esta dissertação visa colmatar a lacuna de conhecimentos, fornecendo previsões ex-ante do potencial de perturbação da terapêutica digital no tratamento de distúrbios da saúde mental. Foi utilizada uma abordagem de investigação mista que consiste em entrevistas a peritos e num inquérito para recolher conhecimentos de mercado tanto da indústria terapêutica digital como da indústria farmacêutica. Em combinação com o conhecimento recolhido da literatura actual, foram feitas previsões sobre o potencial de perturbação da terapêutica digital no mercado dos cuidados de saúde mental. Os resultados indicaram um elevado potencial de perturbação da terapêutica digital no mercado dos cuidados de saúde mental. É improvável uma deslocação completa dos produtos farmacêuticos. Para investigações futuras, especialidades médicas adicionais ou capacidades competitivas das empresas farmacêuticas podem ser examinadas à medida que o ambiente do mercado muda constantemente

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer‐reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state‐of‐the‐art handbook for basic and clinical researchers.DFG, 389687267, Kompartimentalisierung, Aufrechterhaltung und Reaktivierung humaner Gedächtnis-T-Lymphozyten aus Knochenmark und peripherem BlutDFG, 80750187, SFB 841: Leberentzündungen: Infektion, Immunregulation und KonsequenzenEC/H2020/800924/EU/International Cancer Research Fellowships - 2/iCARE-2DFG, 252623821, Die Rolle von follikulären T-Helferzellen in T-Helferzell-Differenzierung, Funktion und PlastizitätDFG, 390873048, EXC 2151: ImmunoSensation2 - the immune sensory syste

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza A, Chang H‐D, Radbruch A, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). European Journal of Immunology. 2021;51(12):2708-3145.The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers.ISSN:0014-2980ISSN:1521-414