Turističke kooperacije i mreže: osnova za stvaranje strateških konkurentnih prednosti u turizmu

Verstärkte Zusammenarbeit bietet für die österreichischen Tourismusuntemehmen eine Möglichkeit auf die veränderten Wettbewerbsbedingungen zu reagieren. Durch Kooperation mit anderen touristischen Leistungsanbietern in unterschiedlichen Formen lassen sich innovative Wege in der Produktgestaltung beschreiten. Verstärkte Zusammenarbeit ermöglicht die von unterschiedlichen Anbieten bereitgestellten touristischen Leistungen in einem Bündel zu vereinen und dem potentiellen Urlauber anzubieten. Dies trägt dazu bei, die derzeitige Position Österreichs am internationalen Tourismusmarkt zu stärken und auf zukünftige Herausforderungen vorzubereiten. Vorliegende Studie verfolgt primär das Ziel, die Bereitschaft der österreichischen Touristiker zur Kooperation, die erwarteten Vorteile und strategischen Stoßbrichtungen sowie potentielle Hemmfaktoren der Netzwerkbildung zu analysieren.Pojačana suradnja nudi austrijskim turističkim poduzećima mogućnost da reagiraju na izmijenjene uvjete u konkurenciji. Putem kooperacije s drugim turističkim sudionicima u turističkoj ponudi može se krenuti u inovacijske zahvate prilikom stvaranja proizvoda. Intenzivirana suradnja omogućuje da se turističke usluge koje pripremaju i nude različiti sudionici objedine i ponude potencijalnom gostu. To doprinosi jačanju sadašnje pozicije Austrije na međunarodnom turističkom tržištu, kao i pripremi za nove izazove. Ova studija primarno slijedi cilj da analizira spremnost austrijskih turističkih radnika na kooperaciju, da analizira očekivane prednosti i strateške udarne smjernice kao i moguće faktore koji koče stvaranje mreže

Olivine or Impact Melt: Nature of the "Orange" Material on Vesta from Dawn

NASA's Dawn mission observed a great variety of colored terrains on asteroid (4) Vesta during its survey with the Framing Camera (FC). Here we present a detailed study of the orange material on Vesta, which was first observed in color ratio images obtained by the FC and presents a red spectral slope. The orange material deposits can be classified into three types, a) diffuse ejecta deposited by recent medium-size impact craters (such as Oppia), b) lobate patches with well-defined edges, and c) ejecta rays from fresh-looking impact craters. The location of the orange diffuse ejecta from Oppia corresponds to the olivine spot nicknamed "Leslie feature" first identified by Gaffey (1997) from ground-based spectral observations. The distribution of the orange material in the FC mosaic is concentrated on the equatorial region and almost exclusively outside the Rheasilvia basin. Our in-depth analysis of the composition of this material uses complementary observations from FC, the visible and infrared spectrometer (VIR), and the Gamma Ray and Neutron Detector (GRaND). Combining the interpretations from the topography, geomorphology, color and spectral parameters, and elemental abundances, the most probable analog for the orange material on Vesta is impact melt

Histological Examination of Collagen and Proteoglycan Changes in Osteoarthritic Menisci

This study sought to examine collagen and proteoglycan changes in the menisci of patients with osteoarthritis (OA). Collagens were examined using picrosirius red, and hematoxylin and eosin. Proteoglycans were examined using safranin-O and alcian blue. Types I and II collagens and aggrecan were examined using immunochemistry. Severe loss of collagens was observed to occur in OA menisci, particularly in the middle and deep zones and collagen networks were less organized than those of normal menisci. In contrast, proteoglycan staining in the middle and deep zones of OA meniscus increased compared to normal control menisci. Immunohistochemistry indicated that types I and II collagens were co-localized and the loss of types I collagen in OA menisci appeared more severe in the middle and deep zones than that in the surface zones. The loss of type II collagen however was severe across all three zones. Immunohistochemistry also indicated elevated aggrecan staining in OA menisci. These findings together indicate that severe loss of collagens and intrameniscal degeneration are hallmarks of OA menisci and that extracellular matrix degeneration occurred in OA menisci follows a pathway different from that occurred in OA articular cartilage. These findings are not only important for a better understanding of the disease process but also important for the development of novel structure-modifying drugs for OA therapy

Undiagnosed osteoid osteoma of the spine presenting as painful scoliosis from adolescence to adulthood: a case report

Presented here is a case of a young woman, with an undiagnosed osteoid osteoma of the spine, which presented with painful scoliosis in adolescence and was treated by bracing until her accession to adulthood. A more thorough investigation, years after the initial one, revealed the tumor. Surgical excision and stabilization offered the long-awaited cure. Misdiagnosis resulted in intractable pain for years, deformity, the discomfort of brace therapy, and the frustration of a prolonged yet ineffective treatment

Gravitational frequency shifts in transformation acoustics

In metamaterial acoustics, it is conceivable that any type of fine-tuned acoustic properties far beyond those found in nature may be transferred to an appropriate medium. Effective design and engineering of these modern acoustic metadevices poses one of the forefront challenges in this field. As a practical example of a new covariant approach for modelling acoustics on spacetime manifolds, we choose to implement the acoustic analogue of the frequency shift due to gravitational time dilation. In accordance with Einstein's equivalence principle, two different spacetimes, corresponding to uniform acceleration or uniform gravity, are considered. For wave propagation in a uniformly accelerating rigid frame, an acoustic event horizon arises. The discussion includes a detailed numerical analysis for both spacetime geometries. Copyright (c) EPLA, 2013MMT wishes to thank MARKUS SCHOBINGER for an introduction to the SBVP MATLAB solver and acknowledges partial support by the Universidad Politecnica de Valencia (PAID-00-12) and the International Office of the Vienna University of Technology.Tung, MM.; Weinmüller, EB. (2013). Gravitational frequency shifts in transformation acoustics. EPL. 101(5):54006-54011. https://doi.org/10.1209/0295-5075/101/54006S5400654011101

Osteoid osteoma of the femur in a 7-month-old infant treated with radiofrequency ablation

Osteoid osteoma occurs most commonly in children, adolescents, and young adults between the ages of 5 and 30 years. In the preschool age group, it is quite uncommon, accounting for only 3–8% of all osteoid osteoma cases. We report a case of osteoid osteoma in a 7-month-old infant, who presented with decreased use of the right lower extremity due to pain. Magnetic resonance imaging (MRI) showed an atypical appearance. A biopsy of the lesion, with histopathological examination, confirmed the diagnosis of osteoid osteoma. Radiofrequency ablation (RFA) of the nidus under computed tomography (CT) guidance was performed. The patient developed a recurrence after 3 months, which was treated with a second RFA. On subsequent follow-up, the infant did not show signs of pain after 1 month. In summary, this case report shows that osteoid osteoma can present in early infancy and can be successfully treated with RFA at this age, however, recurrence after the procedure can occur and close follow-up is recommended

Analysis of meniscal degeneration and meniscal gene expression

<p>Abstract</p> <p>Background</p> <p>Menisci play a vital role in load transmission, shock absorption and joint stability. There is increasing evidence suggesting that OA menisci may not merely be bystanders in the disease process of OA. This study sought: 1) to determine the prevalence of meniscal degeneration in OA patients, and 2) to examine gene expression in OA meniscal cells compared to normal meniscal cells.</p> <p>Methods</p> <p>Studies were approved by our human subjects Institutional Review Board. Menisci and articular cartilage were collected during joint replacement surgery for OA patients and lower limb amputation surgery for osteosarcoma patients (normal control specimens), and graded. Meniscal cells were prepared from these meniscal tissues and expanded in monolayer culture. Differential gene expression in OA meniscal cells and normal meniscal cells was examined using Affymetrix microarray and real time RT-PCR.</p> <p>Results</p> <p>The grades of meniscal degeneration correlated with the grades of articular cartilage degeneration (r = 0.672; P < 0.0001). Many of the genes classified in the biological processes of immune response, inflammatory response, biomineral formation and cell proliferation, including major histocompatibility complex, class II, DP alpha 1 (<it>HLA-DPA1</it>), integrin, beta 2 (<it>ITGB2</it>), ectonucleotide pyrophosphatase/phosphodiesterase 1 (<it>ENPP1</it>), ankylosis, progressive homolog (<it>ANKH</it>) and fibroblast growth factor 7 (<it>FGF7</it>), were expressed at significantly higher levels in OA meniscal cells compared to normal meniscal cells. Importantly, many of the genes that have been shown to be differentially expressed in other OA cell types/tissues, including ADAM metallopeptidase with thrombospondin type 1 motif 5 (<it>ADAMTS5</it>) and prostaglandin E synthase (<it>PTGES</it>), were found to be expressed at significantly higher levels in OA meniscal cells. This consistency suggests that many of the genes detected in our study are disease-specific.</p> <p>Conclusion</p> <p>Our findings suggest that OA is a whole joint disease. Meniscal cells may play an active role in the development of OA. Investigation of the gene expression profiles of OA meniscal cells may reveal new therapeutic targets for OA therapy and also may uncover novel disease markers for early diagnosis of OA.</p