Leading for Learning: Reflective Tools for School and District Leaders

Provides reflective ideas and tools for educators to enhance leadership in learning. Includes key ideas, real examples, and reflective questions that leaders can use can use to assess their organizations, enact strategic plans, and teach colleagues

Lessons from LIMK1 enzymology and their impact on inhibitor design

LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis. Herein, we use X-ray crystallography and activity assays to describe how LIMK1 accomplishes substrate specificity, to suggest a unique ‘rock-and-poke’ mechanism of catalysis and to explore the regulation of the kinase by activation loop phosphorylation. Based on these findings, a differential scanning fluorimetry assay and a RapidFire mass spectrometry activity assay were established, leading to the discovery and confirmation of a set of small-molecule LIMK1 inhibitors. Interestingly, several of the inhibitors were inactive towards the closely related isoform LIMK2. Finally, crystal structures of the LIMK1 kinase domain in complex with inhibitors (PF-477736 and staurosporine, respectively) are presented, providing insights into LIMK1 plasticity upon inhibitor binding

Optimised patient information materials and recruitment to a study of behavioural activation in older adults : an embedded study within a trial [version 1; peer review: awaiting peer review]

YesPrinted participant information about randomised controlled trials is often long, technical and difficult to navigate. Improving information materials is possible through optimisation and user-testing, and may impact on participant understanding and rates of recruitment. Methods: A study within a trial (SWAT) was undertaken within the CASPER trial. Potential CASPER participants were randomised to receive either the standard trial information or revised information that had been optimised through information design and user testing. Results: A total of 11,531 patients were randomised in the SWAT. Rates of recruitment to the CASPER trial were 2.0% in the optimised information group and 1.9% in the standard information group (odds ratio 1.027; 95% CI 0.79 to 1.33; p=0.202). Conclusions: Participant information that had been optimised through information design and user testing did not result in any change to rate of recruitment to the host trial. Registration: ISRCTN ID ISRCTN02202951; registered on 3 June 2009.UK National Institute of Health Research Health Technology Assessment Programme (project number 08/19/04)This article is included in the Studies Within A Trial (SWAT) collection (https://f1000research.com/collections/swat

Influence of Complex Exciton-Phonon Coupling on Optical Absorption and Energy Transfer of Quantum Aggregates

We present a theory that efficiently describes the quantum dynamics of an electronic excitation that is coupled to a continuous, highly structured phonon environment. Based on a stochastic approach to non-Markovian open quantum systems, we develop a dynamical framework that allows us to handle realistic systems where a fully quantum treatment is desired yet the usual approximation schemes fail. The capability of the method is demonstrated by calculating spectra and energy transfer dynamics of mesoscopic molecular aggregates, elucidating the transition from fully coherent to incoherent transfer

Ship incident risk in the areas of Tubbataha and Banc d’Arguin: A case for designation as Particular Sensitive Sea Area?

Since the early 1990's, the International Maritime Organization (IMO) has designated fourteen sea areas as Particular Sensitive Sea Areas (PSSA) that enjoy special protection because of their various important attributes and vulnerability to potential harm by increasing shipping activities. The United Nations Educational, Scientific and Cultural Organization (UNESCO) has identified two possible sites for possible designation as PSSA under IMO: the Banc d'Arguin National Park (Mauritania) and the Tubbataha Reef National Park (Philippines). This article presents an integrated framework for the estimation of total risk exposure due to shipping activities and various risk measures for ships trading in the areas of interest. Using a unique and comprehensive combination of data, we test whether ship specific risk increased over time. The results confirm an increase in the considered risk measures of ships trading through or nearby West Africa (Banc d’Arguin) and South-East Asia (Tubbataha) in general and also close to both regions and therefore support the recommendation for an increased level of protection

Testing Radiatively-Inefficient Accretion Flow Theory: an XMM-Newton Observation of NGC 3998

We present the results of a 10 ks XMM-Newton observation of NGC 3998, a ``type-I'' LINER galaxy. Our goal is to test the extent to which radiatively-inefficient accretion flow (RIAF) models and/or scaled-down AGN models are consistent with the observed properties of NGC 3998. The upper-limit for narrow Fe-K emission derived from a combined fit of the XMM-Newton and BeppoSAX spectra is 25 eV, which is one of the strictest limits to date for any AGN. This significantly rules out Fe-K emission as is expected to be observed in typical Seyfert 1 galaxies. The lack of any reflection features suggests that any optically-thick, geometrically-thin accretion disk must be truncated, probably at a radius of order 100-300 R_s. RIAF models fit the UV to X-ray spectral energy distribution of NGC 3998 reasonably well. In these models the mid-IR flux also constrains the emission from any outer thin disk component that might be present. The UV to X-ray SED is also consistent with a Comptonized thin disk with a very low accretion rate, in which case the lack of Fe-K emission may be due to an ionized accretion disk. Accretion models in general do not account for the observed radio flux of NGC 3998, and the radio flux may be due to a jet. Recent jet models may also be consistent with the nuclear fluxes of NGC 3998 in general, including the X-ray, optical/UV and mid-IR bands. We also derive nuclear fluxes using archival HST WFPC2 data to constrain the SED of NGC 3998. We discuss a possible OM U band and USNO-B detection of the NGC 3998 ULX.Comment: Accepted for publication in ApJ. 13 pages and 5 figures formatted with emulateapj. Version with black-and-white only plots available at http://www.pha.jhu.edu/~ptak/paper

Cavitation inception of a van der Waals fluid at a sack-wall obstacle

Cavitation in a liquid moving past a constraint is numerically investigated by means of a free-energy lattice Boltzmann simulation based on the van der Waals equation of state. The fluid is streamed past an obstacle and, depending on the pressure drop between inlet and outlet, vapor formation underneath the corner of the sack-wall is observed. The circumstances of cavitation formation are investigated and it is found that the local bulk pressure and mean stress are insufficient to explain the phenomenon. Results obtained in this study strongly suggest that the viscous stress, interfacial contributions to the local pressure, and the Laplace pressure are relevant to the opening of a vapor cavity. This can be described by a generalization of Joseph's criterion that includes these contributions. A macroscopic investigation measuring mass flow rate behavior and discharge coefficient was also performed. As theoretically predicted, mass flow rate increases linearly with the square root of the pressure drop. However, when cavitation occurs, the mass flow growth rate is reduced and eventually it collapses into a choked flow state. In the cavitating regime, as theoretically predicted and experimentally verified, the discharge coefficient grows with the Nurick cavitation number