751 research outputs found
Laugh, and the Whole World...Scowls at You: A Defense of the United States\u27 Fair Use Exception for Parody under TRIPs
Developing a Robust Geologic Conceptual Model Using Pseudo 3-D P-Wave Seismic Reflection Data
As part of a multiscale hydrogeophysical and modeling study, a pseudo three-dimensional (3-D) seismic surveywas conducted over a contaminant plume at P area, Savannah River site (South Carolina), to enhance the existing geologicmodel by resolving uncertainties in the lithostratigraphic sequence. The geometry of the dissolved phase trichloroethylene plume, based on initial site characterization, appears to be confined to a narrow corridor within the Eocene sand overlying a clay unit approximately 25m(82 ft) below land surface. Processing the seismic data as a 3-D data volume instead of a series of closely spaced two-dimensional lines allowed for better interpretation of the target horizons, the lower clay, and the sand above the clay. Calibrating the seismic data with existing borehole geophysical logs, core data as well as vertical seismic profiling (VSP) data allowed the seismic data to be inverted from two-way travel-time to depth, thereby facilitating full integration of the seismic data into a solid earth model that is the basic part of a site conceptual model. The outcome was the production of realistic horizon surface maps that show that two channel complexes are located on the section, which are not present in the conceptual model, and that the upper and middle clays are not laterally continuous as previously thought. The geometry of the primary channel has been transposed over the map view of the plume to investigate potential relationships between the shape of the plume and the presence of the channel
Structural and Stratigraphic Control on the Migration of a Contaminant Plume at the P Reactor Area, Savannah River Site, South Carolina
Geophysical methods, including a shallow seismic reflection (SSR) survey, surface and borehole ground-penetrating radar (GPR) data, and electrical resistivity imaging (ERI), were conducted at the Savannah River site (SRS), South Carolina, to investigate the shallow stratigraphy, hydrogeophysical zonation, and the applicability and performance of these geophysical techniques for hydrogeological characterization in contaminant areas. The study site is the P Reactor area located within the upper Atlantic coastal plain, with clastic sediments ranging from Late Cretaceous to Miocene in age. The target of this research was the delineation and prediction of migration pathways of a trichloroethylene (TCE) contaminant plume that originates from the northwest section of the reactor facility and discharges into the nearby Steel Creek. This contaminant plume has been migrating in an east-to-west direction and narrowing away from the source in an area where the general stratigraphy along with the groundwater flow dips to the southeast. Here, we present the results from a stratigraphic and hydrogeophysical characterization of the site using the SSR, GPR, and ERI methods. Although detailed stratigraphic layers were identified in the upper approximately 50 m (164 ft), other major findings include (1) the discovery of a shallow (∼23 m [75 ft] from the ground surface) inverse fault, (2) the detection of a paleochannel system that was previously reported but that seems to be controlled by the reactivation of the interpreted fault, and (3) the finding that the hydraulic gradient seems to have a convergence of groundwater flow near the area. The interpreted fault at the study site appears to be of upper Eocene age and may be associated with other known reactivated faults within the Dunbarton Triassic Basin. The coincident use of the SSR and ERI methods in conjunction with the complementary 50-, 100-, and 200-MHz GPR antennas allowed us to generate a detailed geologic model of the shallow subsurface, suggesting that the migration of the TCE plume is constrained by (1) the paleochannel system with respect to its migration direction, (2) the presence of an inverse fault that may also contribute to the paleochannel growth and structural evolution, and (3) the local groundwater flow volume with respect to its longer and narrower shape away from the source updip stratigraphic bedding
A trans-Indian Ocean hydrographic section at latitude 32°South : data report of RRS Charles Darwin cruise #29
A trans-Indian Ocean hydrographic section employing CTD/O2 profilers was conducted between Africa and Australia during
austral spring 1987. The cruise track ranged between 29°S and 34°S; the average latitude of the crossing was 32°S. The purpose of
the cruise was to explore various aspects of the South Indian Ocean including the characteristics of the core water masses of this
ocean, the strength of the subtropical gyre, the structure and transport of deep western-boundary currents, and the net meridional
heat flux. A total of 109 CTD/O2 profiles with associated rosette water sample measurements and 347 XBT profiles were collected,
supplemented by underway upper ocean velocity, bathymetric and sea surface temperature and salinity data. This report detals the
data collection, calibration, and reduction methods, and summarizes the hydrographic observations.Funding was provided by the National Science Foundation through
Grant No. OCE 86-14497
Comparison of general population, patient, and carer utility values for dementia health states.
Utility values to estimate quality-adjusted life years (QALYs) for use in cost-utility analyses are usually elicited from members of the general population. Public attitudes and understanding of dementia in particular may mean that values elicited from the general population may differ from patients and carers for dementia health states. This study examines how the population impacts utility values elicited for dementia health states using interviewer-administered time tradeoff valuation of health states defined by the dementia-specific preference-based measures DEMQOL-U (patient-report) and DEMQOL-Proxy-U (carer-report). Eight DEMQOL-U states were valued by 78 members of the UK general population and 71 patients with dementia of mild severity. Eight DEMQOL-Proxy-U states were valued by 77 members of the UK general population and 71 carers of patients with dementia of mild severity. Random-effects generalized least squares regression estimated the impact of population, dementia health state, and respondent sociodemographic characteristics on elicited values, finding that values for dementia health states differed by population and that the difference varied across dementia health states. Patients with dementia and carers of patients with dementia gave systematically lower values than members of the general population that were not due to differences in the sociodemographic characteristics of the populations. Our results suggest that the population used to produce dementia health state values could impact the results of cost-utility analyses and potentially affect resource allocation decisions; yet, currently, only general population values are available for usage
Using Rasch analysis to form plausible health states amenable to valuation: the development of CORE-6D from CORE-OM in order to elicit preferences for common mental health problems
Purpose: To describe a new approach for deriving a preference-based index from a condition specific measure that uses Rasch analysis to develop health states.
Methods: CORE-OM is a 34-item instrument monitoring clinical outcomes of people with common mental health problems. CORE-OM is characterised by high correlation across its domains. Rasch analysis was used to reduce the number of items and response levels in order to produce a set of unidimensionally-behaving items, and to generate a credible set of health states corresponding to different levels of symptom severity using the Rasch item threshold map.
Results: The proposed methodology resulted in the development of CORE-6D, a 2-dimensional health state description system consisting of a unidimensionally-behaving 5-item emotional component and a physical symptom item. Inspection of the Rasch item threshold map of the emotional component helped identify a set of 11 plausible health states, which, combined with the physical symptom item levels, will be used for the valuation of the instrument, resulting in the development of a preference-based index.
Conclusions: This is a useful new approach to develop preference-based measures where the domains of a measure are characterised by high correlation. The CORE-6D preference-based index will enable calculation of Quality Adjusted Life Years in people with common mental health problems
Physiological effects of tourism and associated food provisioning in an endangered iguana
© The Author 2013. Deliberately feeding wildlife is an increasingly popular tourism-related activity despite a limited understanding of long-term impacts on the species being fed. As a result, tourist behaviours that may have adverse impacts on imperiled species have often been encouraged without the necessary evaluation or oversight. Here, we report the responses of Northern Bahamian Rock Iguanas (Cyclura cychlura) to human-visitation pressure and associated food provisioning. We compared a variety of blood chemistry parameters of iguanas subjected to supplemental feeding at popular tourist destinations with iguanas occurring on islands where supplemental feeding does not take place. We demonstrate that male and female iguanas inhabiting tourist-visited islands where supplemental feeding occurs do not differ in body condition or baseline stress and stress response (determined by corticosterone levels) compared with iguanas from non-visited islands. Both males and females from tourist-visited sites experienced a greater incidence of endoparasitic infection and atypical loose faeces. Indicators of dietary nutrition, including glucose, potassium, and uric acid values, also differed for both sexes from tourist-visited and unvisited islands. Male iguanas from visited islands differed significantly from those on non-visited islands in calcium, cholesterol, cobalt, copper, magnesium, packed cell volume, selenium, and triglyceride concentrations, whereas female iguanas from visited islands differed significantly in ionized calcium. Although the interpretation of these differences is challenging, chronic biochemical stressors could compromise individual health over time or decrease survivorship during periods of environmental stress. We suggest protocols that can be adopted throughout the region to ensure that supplemental feeding has fewer impacts on these long-lived iguanas
An analysis of fast photochemistry over high northern latitudes during spring and summer using in-situ observations from ARCTAS and TOPSE
Observations of chemical constituents and meteorological quantities obtained during the two Arctic phases of the airborne campaign ARCTAS (Arctic Research of the Composition of the Troposphere from Aircraft and Satellites) are analyzed using an observationally constrained steady state box model. Measurements of OH and HO2 from the Penn State ATHOS instrument are compared to model predictions. Forty percent of OH measurements below 2 km are at the limit of detection during the spring phase (ARCTAS-A). While the median observed-to-calculated ratio is near one, both the scatter of observations and the model uncertainty for OH are at the magnitude of ambient values. During the summer phase (ARCTAS-B), model predictions of OH are biased low relative to observations and demonstrate a high sensitivity to the level of uncertainty in NO observations. Predictions of HO2 using observed CH2O and H2O2 as model constraints are up to a factor of two larger than observed. A temperature-dependent terminal loss rate of HO2 to aerosol recently proposed in the literature is shown to be insufficient to reconcile these differences. A comparison of ARCTAS-A to the high latitude springtime portion of the 2000 TOPSE campaign (Tropospheric Ozone Production about the Spring Equinox) shows similar meteorological and chemical environments with the exception of peroxides; observations of H2O2 during ARCTAS-A were 2.5 to 3 times larger than those during TOPSE. The cause of this difference in peroxides remains unresolved and has important implications for the Arctic HOx budget. Unconstrained model predictions for both phases indicate photochemistry alone is unable to simultaneously sustain observed levels of CH2O and H2O2; however when the model is constrained with observed CH2O, H2O2 predictions from a range of rainout parameterizations bracket its observations. A mechanism suitable to explain observed concentrations of CH2O is uncertain. Free tropospheric observations of acetaldehyde (CH3CHO) are 2–3 times larger than its predictions, though constraint of the model to those observations is sufficient to account for less than half of the deficit in predicted CH2O. The box model calculates gross O3 formation during spring to maximize from 1–4 km at 0.8 ppbv d−1, in agreement with estimates from TOPSE, and a gross production of 2–4 ppbv d−1 in the boundary layer and upper troposphere during summer. Use of the lower observed levels of HO2 in place of model predictions decreases the gross production by 25–50%. Net O3 production is near zero throughout the ARCTAS-A troposphere, and is 1–2 ppbv in the boundary layer and upper altitudes during ARCTAS-B
A comparative study of Tam3 and Ac transposition in transgenic tobacco and petunia plants
Transposition of the Anthirrinum majus Tam3 element and the Zea mays Ac element has been monitored in petunia and tobacco plants. Plant vectors were constructed with the transposable elements cloned into the leader sequence of a marker gene. Agrobacterium tumefaciens-mediated leaf disc transformation was used to introduce the transposable element constructs into plant cells. In transgenic plants, excision of the transposable element restores gene expression and results in a clearly distinguishable phenotype. Based on restored expression of the hygromycin phosphotransferase II (HPTII) gene, we established that Tam3 excises in 30% of the transformed petunia plants and in 60% of the transformed tobacco plants. Ac excises from the HPTII gene with comparable frequencies (30%) in both plant species. When the β-glucuronidase (GUS) gene was used to detect transposition of Tam3, a significantly lower excision frequency (13%) was found in both plant species. It could be shown that deletion of parts of the transposable elements Tam3 and Ac, removing either one of the terminal inverted repeats (TIR) or part of the presumptive transposase coding region, abolished the excision from the marker genes. This demonstrates that excision of the transposable element Tam3 in heterologous plant species, as documented for the autonomous element Ac, also depends on both properties. Southern blot hybridization shows the expected excision pattern and the reintegration of Tam3 and Ac elements into the genome of tobacco plants.
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