Ultrastable Optical Clock with Neutral Atoms in an Engineered Light Shift Trap

An ultrastable optical clock based on neutral atoms trapped in an optical lattice is proposed. Complete control over the light shift is achieved by employing the $5s^2 {}^1S_0 \to 5s5p {}^3P_0$ transition of ${}^{87}{\rm Sr}$ atoms as a "clock transition". Calculations of ac multipole polarizabilities and dipole hyperpolarizabilities for the clock transition indicate that the contribution of the higher-order light shifts can be reduced to less than 1 mHz, allowing for a projected accuracy of better than $10^{-17}$.Comment: 4 pages, 2 figures, accepted for publication in Phys. Rev. Let

DATASET2050 D3.2 - Future Passenger Demand Profile

The FlightPath 2050 goal of enabling 90 per cent of European passengers to complete their door-to-door journey within four hours is a very challenging task. A major objective of the DATASET2050 project is to deliver insight into both current and future processes relating to the European transport system in this context. The deliverable D3.2 "Future Passenger Demand Profile" focuses on the future demand side of European (air) transport. Namely, the first goal is to develop a range of passenger profiles for the year 2035 and to provide implications for passenger profiles for 2050. For this purpose, the development of passenger characteristics - including demographic, geographic, socio-economic and behavioural aspects as well as particular mobility patterns - is analysed using available European data and forecasts. Based on this analysis, on specific mobility behaviour of the different member states (EU28 and EFTA countries) as well as on a high-level-factor identification, six different passenger profiles for 2035 are developed. These six profiles differ by main travel purpose (private, business and leisure, which is the combination of business and leisure trips), predominant age group, income level (low, medium, high) and several other characteristics. Furthermore, a demand model is applied showing the high relevance of gross domestic product (GDP) and education for a steady growth of passenger traffic volume in the EU28 and EFTA countries until 2050. The outcomes of the current deliverable will be put in contrast with those coming from D4.2 (Future supply profile), enabling thus a comprehensive assessment on the European door-to-door mobility in the future. Specifically, the deliverable results will be used in D5.1 (Mobility assessment), D5.2 (Assessment execution) and D5.3 (Novel concept foundations for European mobility)

Production and trapping of carbon clusters for absolute mass measurements at ISOLTRAP

Singly-charged carbon clusters C/sub n//sup +/ (n >or= 1) have been produced by laser-induced desorption and fragmentation of C/sub 60/ fullerenes and have been injected into and stored in the Penning trap system of the ISOLTRAP mass spectrometer at ISOLDE/CERN. The present study is the first step to extend the until now direct mass measurements at ISOLTRAP to absolute mass measurements by using clusters of /sup 12/C. (10 refs)

DATASET2050 D5.2 - Assessment execution

Over recent years there has been an increasing effort to enhance European door-to-door mobility. Several initiatives have focused on improving the seamlessness, effectiveness and predictability of the European transport system through improving the related systems, technologies, concepts or processes. In an effort to establish a concrete methodology for assessing the system's current performance, this document describes a data-driven model centred on the current and future performance of European mobility. Included in this study, but not restricted to, is data and insight related to the Flightpath 2050 goal that states "90% of travellers within Europe [will be] able to complete their journey, door-to-door within four hours" where this journey includes at least one leg by air. In this report, the current door-to-door times and prices are quantified, dis-aggregated by passenger profile, door-to-door phase (door-kerb-gate-gate-kerb-door) and airport considered. In addition, major bottlenecks are identified that are hindering the 4-hour goal

Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome

AIMS/HYPOTHESIS: Numerous new genes have recently been identified in genome-wide association studies for type 2 diabetes. Most are highly expressed in beta cells and presumably play important roles in their function. However, these genes account for only a small proportion of total risk and there are likely to be additional candidate genes not detected by current methodology. We therefore investigated islets from the polygenic New Zealand mouse (NZL) model of diet-induced beta cell dysfunction to identify novel genes and pathways that may play a role in the pathogenesis of diabetes. METHODS: NZL mice were fed a diabetogenic high-fat diet (HF) or a diabetes-protective carbohydrate-free HF diet (CHF). Pancreatic islets were isolated by laser capture microdissection (LCM) and subjected to genome-wide transcriptome analyses. RESULTS: In the prediabetic state, 2,109 islet transcripts were differentially regulated (>1.5-fold) between HF and CHF diets. Of the genes identified, 39 (e.g. Cacna1d, Chd2, Clip2, Igf2bp2, Dach1, Tspan8) correlated with data from the Diabetes Genetics Initiative and Wellcome Trust Case Control Consortium genome-wide scans for type 2 diabetes, thus validating our approach. HF diet induced early changes in gene expression associated with increased cell-cycle progression, proliferation and differentiation of islet cells, and oxidative stress (e.g. Cdkn1b, Tmem27, Pax6, Cat, Prdx4 and Txnip). In addition, pathway analysis identified oxidative phosphorylation as the predominant gene-set that was significantly upregulated in response to the diabetogenic HF diet. CONCLUSIONS/INTERPRETATION: We demonstrated that LCM of pancreatic islet cells in combination with transcriptional profiling can be successfully used to identify novel candidate genes for diabetes. Our data strongly implicate glucose-induced oxidative stress in disease progression

Effect of anisotropic impurity scattering in superconductors

We discuss the weak-coupling BCS theory of a superconductor with the impurities, accounting for their anisotropic momentum-dependent potential. The impurity scattering process is considered in the t-matrix approximation and its influence on the superconducting critical temperature is studied in the Born and unitary limit for a d- and (d+s)-wave superconductors. We observe a significant dependence of the pair-breaking strength on the symmetry of the scattering potential and classify the impurity potentials according to their ability to alter T_c. A good agreement with the experimental data for Zn doping and oxygen irradiation in the overdoped cuprates is found.Comment: 31 pages, RevTex, 15 PostScript figure

A cylindrical Penning trap for capture, mass selective cooling, and bunching of radioactive ion beams

A Penning trap ion accumulator, cooler, and buncher for low energy ion beams has been developed for the ISOLTRAP mass spectrometer at ISOLDE/CERN. A cylindrical electrode configuration is used for the creation of a nested trapping potential. This is required for efficient accumulation of externally produced ions and for high mass selectivity by buffer gas cooling. The design goal of a mass resolving power of about $1\cdot 10^{5}$ has been achieved. Isobar separation has been demonstrated for radioactive rare earth ion beams delivered by the ISOLDE on-line mass separator

High-accuracy mass determination of neutron-rich rubidium and strontiumiIsotopes

The penning-trap mass spectrometer ISOLTRAP, installed at the on-line isotope separator ISOLDE at CERN, has been used to measure atomic masses of $^{88,89,90m,91,92,93,94}$Rb and $^{91- 95}$Sr. Using a resolving power of R $\!\scriptstyle\approx$1 million a mass accuracy of typically 10 keV was achieved for all nuclides. Discrepancies with older data are analyzed and discussed, leading to corrections to those data. Together with the present ISOLTRAP data these corrected data have been used in the general mass adjustment