Konfigurerbar systembrygga mellan Jourhavande bibliotekarie och Fråga biblioteket: slutrapport

Arbetet med att utveckla en systembrygga för en fördjupad samverkan inom området virtuell referenstjänst inom och mellan bibliotek och bibliotekarier i olika bibliotekstyper, innebär att en infrastruktur finns för att ta hand om alla frågor på ett systematiskt sätt. Möjligheterna för en samordning av en virtuell referenstjänst på nationell nivå ger inte bara kostnadseffektivitet utan också driftsäkerhet samt möjlighet att utveckla en kunskapsbank för att tillvarata och återanvända den kunskap som skapas vid referenssamtalen. Fråga biblioteket har med sin nuvarande kunskapsbank visat att det går att bygga upp en mycket omfattande sådan inom en rimlig tidsperiod. En nationell lösning med systembryggan som grund gör det möjligt att arbeta lokalt, regionalt och nationellt i ett gränsöverskridande samarbete mellan olika biblioteksorganisationer. En referenstjänst på webben bidrar också till att öka tillgängligheten till bibliotekens tjänster. Att delta i ett arbete med virtuella referenstjänster, där samverkan på olika nivåer mellan bibliotek och bibliotekarier är möjlig, kan också bidra till en kompetensutveckling inom området. En referenstjänst på webben bidrar också till att öka tillgängligheten till bibliotekens tjänster. Att delta i ett arbete med virtuella referenstjänster, där samverkan på olika nivåer mellan bibliotek och bibliotekarier är möjlig, kan också bidra till en kompetensutveckling inom området. Systembryggan i en kort sammanfattning: Ett flexibelt system för hantering av alla e-frågor En kollaborativ lösning som även innebär fristående tjänster lokalt Möjlighet att skapa helt nya tjänster för samverkan En väl utvecklad managementdel med bl.a. uttag av rapporter på lokal, regional och nationell nivå och möjlighet att skapa enkäter på olika nivåer Full frihet att själv skräddarsy layout och texter med exempelvis egna loggor Möjlighet till uppföljning av alla frågor när som helst Funktioner för back office mellan samtliga bibliotek av alla bibliotekstype

Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family

Developmental dyslexia is the most common learning disorder in children. Problems in reading and writing are likely due to a complex interaction of genetic and environmental factors, resulting in reduced power of studies of the genetic factors underlying developmental dyslexia. Our approach in the current study was to perform exome sequencing of affected and unaffected individuals within an extended pedigree with a familial form of developmental dyslexia. We identified a two-base mutation, causing a p.R229L amino acid substitution in the centrosomal protein 63 kDa (CEP63), co-segregating with developmental dyslexia in this pedigree. This mutation is novel, and predicted to be highly damaging for the function of the protein. 3D modelling suggested a distinct conformational change caused by the mutation. CEP63 is localised to the centrosome in eukaryotic cells and is required for maintaining normal centriole duplication and control of cell cycle progression. We found that a common polymorphism in the CEP63 gene had a significant association with brain white matter volume. The brain regions were partly overlapping with the previously reported region influenced by polymorphisms in the dyslexia susceptibility genes DYX1C1 and KIAA0319. We hypothesise that CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated.Peer reviewe

Specialist paediatric dentistry in Sweden 2008 - a 25-year perspective

Background. Paediatric dentistry in Sweden has been surveyed four times over the past 25 years. During this period postgraduate training, dental health, and the organization of child dental care have changed considerably. Aim. To investigate services provided by specialists in paediatric dentistry in Sweden in 2008, and to compare with data from previous surveys. Design. The same questionnaire was sent to all 30 specialist paediatric dental clinics in Sweden that had been used in previous surveys. Comparisons were made with data from 1983, 1989, 1996 and 2003. Results. Despite an unchanged number of specialists (N = 81 in 2008), the number of referrals had increased by 16% since 2003 and by almost 50% since 1983. There was greater variation in reasons for referrals. The main reason was still dental anxiety/behaviour management problems in combination with dental treatment needs (27%), followed by medical conditions/disability (18%), and high caries activity (15%). The use of different techniques for conscious sedation as well as general anaesthesia had also increased. Conclusions. The referrals to paediatric dentistry continue to increase, leading to a heavy work load for the same number of specialists. Thus, the need for more paediatric dentists remains

Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family

Developmental dyslexia is the most common learning disorder in children. Problems in reading and writing are likely due to a complex interaction of genetic and environmental factors, resulting in reduced power of studies of the genetic factors underlying developmental dyslexia. Our approach in the current study was to perform exome sequencing of affected and unaffected individuals within an extended pedigree with a familial form of developmental dyslexia. We identified a two-base mutation, causing a p.R229L amino acid substitution in the centrosomal protein 63 kDa (CEP63), co-segregating with developmental dyslexia in this pedigree. This mutation is novel, and predicted to be highly damaging for the function of the protein. 3D modelling suggested a distinct conformational change caused by the mutation. CEP63 is localised to the centrosome in eukaryotic cells and is required for maintaining normal centriole duplication and control of cell cycle progression. We found that a common polymorphism in the CEP63 gene had a significant association with brain white matter volume. The brain regions were partly overlapping with the previously reported region influenced by polymorphisms in the dyslexia susceptibility genes DYX1C1 and KIAA0319. We hypothesise that CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated