Vertical use cases in the Finnish 5G test network

Abstract The Finnish 5G test network (5GTN) supports development of new network technologies, and services and applications on top of these. It is developed and operated in collaboration with partners from different domains such as research, telecommunications, internet of things, software services, and data analytics. 5GTN is designed to support building products and services on top of latest and upcoming network technologies. A current example of this is exploring opportunities for new services, and impacts from 5G technologies, such as higher datarates, lower delays, and dense deployments. In this paper, we describe a set of use cases from different domain verticals, built on top of 5GTN, and the experiences so far from those use cases

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.Peer reviewe