741 research outputs found
Evaluation of effectiveness of various devices for attenuation of trailing vortices based on model tests in a large towing basin
The effectiveness of various candidate aircraft-wing devices for attenuation of trailing vortices generated by large aircraft is evaluated on basis of results of experiments conducted with a 0.03-scale model of a Boeing 747 transport aircraft using a technique developed at the HYDRONAUTICS Ship Model Basin. Emphasis is on the effects produced by these devices in the far-field (up to 8 kilometers downstream of full-scale generating aircraft) where the unaltered vortex-wakes could still be hazardous to small following aircraft. The evaluation is based primarily on quantitative measurements of the respective vortex velocity distributions made by means of hot-film probe traverses in a transverse plane at selected stations downstream. The effects of these altered wakes on rolling moment induced on a small following aircraft are also studied using a modified lifting-surface theory with a synthesized Gates Learjet as a typical example. Lift and drag measurements concurrently obtained in the model tests are used to appraise the effects of each device investigated on the performance characteristics of the generating aircraft
Mammalian Sperm Motility: Observation and Theory
Mammalian spermatozoa motility is a subject of growing importance because of rising human infertility and the possibility of improving animal breeding. We highlight opportunities for fluid and continuum dynamics to provide novel insights concerning the mechanics of these specialized cells, especially during their remarkable journey to the egg. The biological structure of the motile sperm appendage, the flagellum, is described and placed in the context of the mechanics underlying the migration of mammalian sperm through the numerous environments of the female reproductive tract. This process demands certain specific changes to flagellar movement and motility for which further mechanical insight would be valuable, although this requires improved modeling capabilities, particularly to increase our understanding of sperm progression in vivo. We summarize current theoretical studies, highlighting the synergistic combination of imaging and theory in exploring sperm motility, and discuss the challenges for future observational and theoretical studies in understanding the underlying mechanics.\ud
Acronyms and Definitions\ud
Acrosome: the cap of the sperm head containing enzymes allowing penetration of the zona pellucida via the acrosome reaction\ud
Adenosine triphosphate (ATP): the currency unit of chemical energy transfer in living cells\ud
Axoneme: a phylogenetically conserved structure within the eukaryotic flagellum consisting of a ring of nine microtubule doublets and a central pair, frequently referred to as 9 + 2\ud
Bending moment density: the moment per unit length associated with flagellar bending; it can be divided into a hydrodynamic moment, an elastic moment (from the flagellar bending stiffness), an active moment (generated by dyneins exerting forces between adjacent microtubule doublets), and a passive moment resisting shear\ud
Capacitation: the physiological state of a sperm required for fertilization, which is accompanied by the motility patterns associated with hyperactivation, characterized in saline by high-amplitude asymmetric beating\ud
Central pair: a pair of microtubules along the length of the axoneme, symmetrically and slightly offset from the axoneme centerline\ud
Cumulus oophorus: the outer vestment of the mammalian egg consisting of hundreds of cells radiating out from the egg embedded within a non-Newtonian hyaluronic acid gel\ud
Dynein: a molecular motor within the axoneme, attached between adjacent microtubule doublets, that exerts a shearing force to induce axonemal bending\ud
Flagellum: a motile cellular appendage that drives the swimming of sperm and other cells; this article focuses on the eukaryotic flagellum\ud
Microtubule doublet: a pair of proteinaceous filament structures running the length of the axoneme; dyneins drive their bending, which induces flagellar motion\ud
Mid-piece: the region of a sperm flagellum with a mitochondrial sheath, where ATP is generated\ud
Oocyte: the egg\ud
Outer dense fibers and fibrous sheath: accessory structures reinforcing the mammalian sperm flagellum; the combined axoneme and accessory structures are referred to as 9+9+2\ud
Resistive-force theory: an approximation for the local drag of a slender filament element in Stokes flow (or a viscoelastic generalization thereof)\ud
Rheotaxis: directed motility in response to the influence of fluid flow\ud
Shear: in the context of the flagellum, the relative movement of adjacent microtubule doublets\ud
Slender-body theory: an improved approximation for the local drag on a slender filament element in Stokes flow (or a viscoelastic generalization thereof)\ud
Zona pellucida: a tough glycoprotein coat between the human egg and the cumulus oophorus, which a sperm must penetrate for successful fertilizatio
A Catalog of Absorption Lines in Eight HST/STIS E230M 1.0 < z < 1.7 Quasar Spectra
We have produced a catalog of line identifications and equivalent width
measurements for all absorption features in eight ultraviolet echelle quasar
spectra. These spectra were selected as having the highest signal-to-noise
among the HST/STIS spectra obtained with the E230M grating. We identify 56
metal-line systems toward the eight quasars, and present plots of detected
transitions, aligned in velocity-space. We found that about 1/4 - 1/3 of the
features in the Lya forest region, redward of the incidence of the Lyb forest,
are metal lines. High ionization transitions are common. We see both O VI and C
IV in 88 - 90% of the metal-line systems for which the spectra cover the
expected wavelength. Si III is seen in 58%, while low ionization absorption in
C II, Si II, and/or Al II is detected in 50% of the systems for which they are
covered. This catalog will facilitate future studies of the Lya forest and of
metal-line systems of various types.Comment: 13 pages, 2 figures, submitted to Monthly Notices of the Royal
Astronomical Society, a complete version with the appendix and all figures is
available at http://www.astro.psu.edu/users/misawa/pub/Paper/qalcat.pdf.g
Human sperm accumulation near surfaces: a simulation study
A hybrid boundary integral/slender body algorithm for modelling flagellar cell motility is presented. The algorithm uses the boundary element method to represent the ‘wedge-shaped’ head of the human sperm cell and a slender body theory representation of the flagellum. The head morphology is specified carefully due to its significant effect on the force and torque balance and hence movement of the free-swimming cell. The technique is used to investigate the mechanisms for the accumulation of human spermatozoa near surfaces. Sperm swimming in an infinite fluid, and near a plane boundary, with prescribed planar and three-dimensional flagellar waveforms are simulated. Both planar and ‘elliptical helicoid’ beating cells are predicted to accumulate at distances of approximately 8.5–22 μm from surfaces, for flagellar beating with angular wavenumber of 3π to 4π. Planar beating cells with wavenumber of approximately 2.4π or greater are predicted to accumulate at a finite distance, while cells with wavenumber of approximately 2π or less are predicted to escape from the surface, likely due to the breakdown of the stable swimming configuration. In the stable swimming trajectory the cell has a small angle of inclination away from the surface, no greater than approximately 0.5°. The trapping effect need not depend on specialized non-planar components of the flagellar beat but rather is a consequence of force and torque balance and the physical effect of the image systems in a no-slip plane boundary. The effect is relatively weak, so that a cell initially one body length from the surface and inclined at an angle of 4°–6° towards the surface will not be trapped but will rather be deflected from the surface. Cells performing rolling motility, where the flagellum sweeps out a ‘conical envelope’, are predicted to align with the surface provided that they approach with sufficiently steep angle. However simulation of cells swimming against a surface in such a configuration is not possible in the present framework. Simulated human sperm cells performing a planar beat with inclination between the beat plane and the plane-of-flattening of the head were not predicted to glide along surfaces, as has been observed in mouse sperm. Instead, cells initially with the head approximately 1.5–3 μm from the surface were predicted to turn away and escape. The simulation model was also used to examine rolling motility due to elliptical helicoid flagellar beating. The head was found to rotate by approximately 240° over one beat cycle and due to the time-varying torques associated with the flagellar beat was found to exhibit ‘looping’ as has been observed in cells swimming against coverslips
Replacing IUI with IVF for initial treatment of unexplained infertility: why this NICE recommendation is cause for concern
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