Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range

Orthobunyaviruses include several recently emerging viruses of significant medical and veterinary importance. There is currently very limited understanding on what determines the host species range of these pathogens. In this study we discovered that BST-2/tetherin restricts orthobunyavirus replication in a host-specific manner. We show that viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (Schmallenberg virus and others) are restricted by human BST-2 but not by the sheep orthologue. We also show that BST-2 blocks orthobunyaviruses replication by reducing the amount of envelope glycoprotein into viral particles egressing from infected cells. This is the first study identifying a restriction factor that correlates with species susceptibility to orthobunyavirus infection. This work provides insight to help us dissect the adaptive changes that bunyaviruses require to cross the species barrier and emerge into new species

Towers to Trenches: The Future of the Affordable Health Care Act, A Legal Perspective

Towers to Trenches: The Future of the Affordable Health Care Act, A Legal Perspective Join us as we examine how to advise health care clients in a time of uncertainty and discuss how health care entities are bracing for the changes. Speakers: Russell Sullivan, partner at McGuire Woods and former staff director for the U.S. Senate Finance Committee Kirkland McGhee (J.D. ’85), vice president and senior counsel at Kaiser Permanente Charlotte Combre (J.D. ’97), partner at Baker Hostetler Moderator: Erin Fuse Brown, Assistant Professor of La