Correlation between frontal lobe oxy-hemoglobin and severity of depression assessed using near-infrared spectroscopy

AbstractIntroductionThe search for objective biomarkers of psychiatric disorders has a long history. Despite this, no universally accepted instruments or methods to detect biomarkers have been developed. One potential exception is near-infrared spectroscopy, although interpreting the measures of blood flow recorded with this technique remains controversial. In this study, we aimed to investigate the relationship between recorded blood flow and depression severity assessed using the Hamilton depression scale in patients with various psychiatric disorders.MethodsEnrolled patients (n=43) had DSM-IV diagnoses of major depressive disorder (n=25), bipolar disorder I (n=5), schizophrenia (n=3), dysthymic disorder (n=3), psychotic disorder (n=3), panic disorder (n=2), and Obsessive Compulsive Disorder (n=2). The verbal fluency task was administered during blood flow recording from the frontal and temporal lobes.ResultsWe found that severity of depression was negatively correlated with the integral value of blood flow in the frontal lobe, irrespective of psychiatric diagnosis (F=5.94, p=0.02).DiscussionOur results support blood flow in the frontal lobe as a potential biomarker of depression severity across various psychiatric disorders.LimitationLimited sample size, no replication in the second set

Use of the Structure of Blood Vessel for Detection of Brain Aneurysm and Route Search to Brain Aneurysm

Abstract: In this research, we constructed functions that are necessary for the operation simulation system which assists medical students to inhibit brain aneurysm from exploding. The system reported in this paper is “detection of blood vessels”, “detection of brain aneurysm ” and “route planning to brain aneurysm”. Not only the detection method but also the method to reduce the miss detection is realized for the detection of blood vessel. Finally, the future work will be shown including construction of head model consisting of artery, vein, brain and craniu

Low energy radioactivity BG model in Super-Kamiokande detector from SK-IV data

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Follow-up of GWTC-2 gravitational wave events with neutrinos from the Super-Kamiokande detector

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