Inflammation as a Central Mechanism in Alzheimer\u27s Disease

Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain\u27s resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms

Ribbons on the CBR Sky: A Powerful Test of a Baryon Symmetric Universe

If the Universe consists of domains of matter and antimatter, annihilations at domain interfaces leave a distinctive imprint on the Cosmic Background Radiation (CBR) sky. The signature is anisotropies in the form of long, thin ribbons of width $\theta_W\sim 0.1^\circ$, separated by angle $\theta_L\simeq 1^\circ(L/100h^{-1}{Mpc})$ where L is the characteristic domain size, and y-distortion parameter $y \approx 10^{-6}$. Such a pattern could potentially be detected by the high-resolution CBR anisotropy experiments planned for the next decade, and such experiments may finally settle the question of whether or not our Hubble volume is baryon symmetric.Comment: LaTeX, 10 pages, 4 figures in epsf. Revised version corrects a couple of relevant mistake

Sharing Social Network Data: Differentially Private Estimation of Exponential-Family Random Graph Models

Motivated by a real-life problem of sharing social network data that contain sensitive personal information, we propose a novel approach to release and analyze synthetic graphs in order to protect privacy of individual relationships captured by the social network while maintaining the validity of statistical results. A case study using a version of the Enron e-mail corpus dataset demonstrates the application and usefulness of the proposed techniques in solving the challenging problem of maintaining privacy \emph{and} supporting open access to network data to ensure reproducibility of existing studies and discovering new scientific insights that can be obtained by analyzing such data. We use a simple yet effective randomized response mechanism to generate synthetic networks under $\epsilon$-edge differential privacy, and then use likelihood based inference for missing data and Markov chain Monte Carlo techniques to fit exponential-family random graph models to the generated synthetic networks.Comment: Updated, 39 page

Investigation of shock waves in explosive blasts using fibre optic pressure sensors

The published version of this article may be accessed at the link below. Copyright @ IOP Publishing, 2006.We describe miniature all-optical pressure sensors, fabricated by wafer etching techniques, less than 1 mm(2) in overall cross-section with rise times in the mu s regime and pressure ranges typically 900 kPa (9 bar). Their performance is suitable for experimental studies of the pressure-time history for test models exposed to shocks initiated by an explosive charge. The small size and fast response of the sensors promises higher quality data than has been previously available from conventional electrical sensors, with potential improvements to numerical models of blast effects. Results from blast tests are presented in which up to six sensors were multiplexed, embedded within test models in a range of orientations relative to the shock front.Support from the UK Engineering&Physical Sciences Research Council and Dstl Fort Halstead through the MoD Joint Grants Scheme are acknowledged. WN MacPherson is supported by an EPSRC Advanced Research Fellowship

Completing Natural Inflation

If the inflaton is a pseudo-scalar axion, the axion shift symmetry can protect the flatness of its potential from too large radiative corrections. This possibility, known as natural inflation, requires an axion scale which is greater than the (reduced) Planck scale. It is unclear whether such a high value is compatible with an effective field theoretical description, and if the global axionic symmetry survives quantum gravity effects. We propose a mechanism which provides an effective large axion scale, although the original one is sub-Planckian. The mechanism is based on the presence of two axions, with a potential provided by two anomalous gauge groups. The effective large axion scale is due to an almost exact symmetry between the couplings of the axions to the anomalous groups. We also comment on a possible implementation in heterotic string theory.Comment: 9 pages, 1 figur

Fine tuning and the ratio of tensor to scalar density fluctuations from cosmological inflation

The form of the inflationary potential is severely restricted if one requires that it be natural in the technical sense, i.e. terms of unrelated origin are not required to be correlated. We determine the constraints on observables that are implied in such natural inflationary models, in particular on $r$, the ratio of tensor to scalar perturbations. We find that the naturalness constraint does not require $r$ to be lare enough to be detectable by the forthcoming searches for B-mode polarisation in CMB maps. We show also that the value of $r$ is a sensitive discriminator between inflationary models.Comment: 8 pages LaTeX; clarifications and a reference added; to appear in JCA

Unstable superheavy relic particles as a source of neutrinos responsible for the ultrahigh-energy cosmic rays

Decays of superheavy relic particles may produce extremely energetic neutrinos. Their annihilations on the relic neutrinos can be the origin of the cosmic rays with energies beyond the Greisen-Zatsepin-Kuzmin cutoff. The red shift acts as a cosmological filter selecting the sources at some particular value z_e, for which the present neutrino energy is close to the Z pole of the annihilation cross section. We predict no directional correlation of the ultrahigh-energy cosmic rays with the galactic halo. At the same time, there can be some directional correlations in the data, reflecting the distribution of matter at red shift z=z_e. Both of these features are manifest in the existing data. Our scenario is consistent with the neutrino mass reported by Super-Kamiokande and requires no lepton asymmetry or clustering of the background neutrinos.Comment: 3 pages, revtex; references adde

Evolution of Second-Order Cosmological Perturbations and Non-Gaussianity

We present a second-order gauge-invariant formalism to study the evolution of curvature perturbations in a Friedmann-Robertson-Walker universe filled by multiple interacting fluids. We apply such a general formalism to describe the evolution of the second-order curvature perturbations in the standard one-single field inflation, in the curvaton and in the inhomogeneous reheating scenarios for the generation of the cosmological perturbations. Moreover, we provide the exact expression for the second-order temperature anisotropies on large scales, including second-order gravitational effects and extend the well-known formula for the Sachs-Wolfe effect at linear order. Our findings clarify what is the exact non-linearity parameter f_NL entering in the determination of higher-order statistics such as the bispectrum of Cosmic Microwave Background temperature anisotropies. Finally, we compute the level of non-Gaussianity in each scenario for the creation of cosmological perturbations.Comment: 14 pages, LaTeX file. Further comments adde