1,585 research outputs found

    Level 2: Comment Devenir Grand et Fort / How to Become Big and Strong

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    THIS BOOK IS DEDICATED TO CHILDREN WHO WANT TO READ AND LEARN This book is for you from me. I give permission to the organization Seedsof Knowledge to use it for any purpose. About the Author: My name is Ron King. I\u27m American. I am a student at KSU University. I study English. I like to play with my little brother. This book is the result of a civic, cultural, and linguistic project in the French class of Professor Viakinnou-Brinson on March 12, 2018. CE LIVRE EST DÉDIÉ AUX ENFANTS QUI VEULENT LIRE ET APPRENDRE. Ce livre est pour toi de ma part. Je donne l’autorisation Ă  l’organisme «Seedsof Knowledge» l’autorisation de l’utiliser Ă  des fins. Au sujet de l’auteur: Je m’appelle Ron King. Je suis amĂ©ricain. Je suis Ă©tudiant de l’universitĂ© de KSU. J’étudie l’anglais. J’aime jouer avec mon petit frĂšre. Ce livre est le rĂ©sultat d’un projet civique, culturel, et linguistique dans la classe de français du Professeur Viakinnou-Brinsonle 12, mars 2018.https://digitalcommons.kennesaw.edu/globallib/1021/thumbnail.jp

    Soil Salinity and Stomatal Conductance on Chaparral Plants

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    In our experiment we evaluated the soil salinity and corresponding stomatal conductance rates of Malosma laurina and Rhus integrifolia located near the coast and farther inland. Our prediction was that stomatal conductance would vary with the change in location of each species. Stomatal conductance was measured using a simple diffusion porometer and soil salinity was measured using a refractometer. We concluded that soil salinity caused a decline in stomatal conductance in both chaparral species. M. laurina was also found to be more sensitive to an increase in soil salinity, as its stomatal conductance rates declined more than that of R. integrifolia

    Disulphide production by Ero1alpha-PDI relay is rapid and effectively regulated

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    The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds. Both the oxidase Ero1alpha and the oxidoreductase protein disulphide isomerase (PDI) strongly contribute to the rapid recovery kinetics, but experiments in ERO1-deficient cells indicate the existence of parallel pathways for disulphide generation. We find PDI to be the main substrate of Ero1alpha, and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3. We also show for the first time that the oxidation level of PDIs and glutathione is precisely regulated. Apparently, this is achieved neither through ER import of thiols nor by transport of disulphides to the Golgi apparatus. Instead, our data suggest that a dynamic equilibrium between Ero1- and glutathione disulphide-mediated oxidation of PDIs constitutes an important element of ER redox homeostasis

    Ares I First Stage Booster Deceleration System: An Overview

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    In 2005, the Congressional NASA Authorization Act enacted a new space exploration program, the "Vision for Space Exploratien". The Constellation Program was formed to oversee the implementation of this new mission. With an intent not simply to support the International Space Station, but to build a permanent outpost on the Moon and then travel on to explore ever more distant terrains, the Constellation Program is supervising the development of a brand new fleet of launch vehicles, the Ares. The Ares lineup will include two new launch vehicles: the Ares I Crew Launch Vehicle and the Ares V Cargo Launch Vehicle. A crew exploration vehicle, Orion, will be launched on the Ares I. It will be capable of docking with the Space Station, the lunar lander, Altair, and the Earth Departure Stage of Ares V. The Ares V will be capable of lifting both large-scale hardware and the Altair into space. The Ares First Stage Team is tasked with developing the propulsion system necessary to liftoff from the Earth and loft the entire Ares vehicle stack toward low Earth orbit. The Ares I First Stage booster is a 12-foot diameter, five-segment, reusable solid rocket booster derived from the Space Shuttle's four segment reusable solid rocket booster (SRB). It is separated from the Upper Stage through the use of a Deceleration Subsystem (DSS). Booster Tumble Motors are used to induce the pitch tumble following separation from the Upper Stage. The spent Ares I booster must be recoverable using a parachute deceleration system similar to that of the Shuttle SRB heritage system. Since Ares I is much heavier and reenters the Earth's atmosphere from a higher altitude at a much higher velocity than the SRB, all of the parachutes must be redesigned to reliably meet the operational requisites of the new launch vehicles. This paper presents an overview of this new booster deceleration system. It includes comprehensive detail of the parachute deceleration system, its design and deployment sequences, including how and why it is being developed, the requirements it must meet, and the testing involved in its implementation

    Cardiorespiratory requirements of the 6-min walk test in patients with left ventricular systolic disfunction and no major structural heart disease

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    The six-minute walk test (6-MWT) is widely used to assess functional status in patients with chronic heart failure (CHF). The aims of the present study were: (1) to compare metabolic gas exchange during the 6-MWT in older patients with left ventricular systolic dysfunction (LVSD) and in breathless patients with no major structural heart disease (MSHD); (2) to determine the exercise intensity of the 6-MWT relative to peak oxygen uptake; (3) to establish the accuracy and reproducibility of the Metamax 3B ergospirometer during an incremental workload. Twenty four older patients with LVSD (19 male; age 76 ± 5 years; BMI 27 ± 4), and 18 patients with no MSHD (12 male; age 75 ± 8 years; BMI 27 ± 4) attended on consecutive days at the same time. Patients completed a 6-MWT with metabolic gas exchange measurements using the Metamax 3B portable ergospirometer, and an incremental cycle ergometry test using both the Metamax 3B and Oxycon Pro metabolic cart. Patients returned and performed a second 6-MWT and an incremental treadmill test, metabolic gas exchange was measured with the Metamax 3B. In patients with LVSD, the 6-MWT was performed at a higher fraction of maximal exercise capacity (p = 0.02). The 6-MWT was performed below the anaerobic threshold in patients with LVSD (83 %) and in patients with no MSHD (61 %). The Metamax 3B showed satisfactory to high accuracy at 10 W and 20 W in patients with LVSD (r = 0.77 - 0.97, p < 0.05), and no MSHD (r = 0.76 - 0.94, p < 0.05). Metabolic gas exchange variables measured during the 6-MWT showed satisfactory to high day-to-day reproducibility in patients with LVSD (ICC = 0.75 - 0.98), but a higher variability was evident in participants with no MSHD (ICC = 0.62 - 0.97). The Metamax 3B portable ergospirometer is an accurate and reproducible device during submaximal, fixed rate exercise in older patients with LVSD and no MSHD. In elderly patients with LVSD and no MSHD, the 6-MWT should not be considered a maximal test of exercise capacity but rather a test of submaximal exercise performance. Our study demonstrates that the 6-MWT takes place at a higher proportion of peak oxygen uptake in patients with LVSD compared to those with no MSHD, and may be one reason why fatigue is a more prominent symptom in these patients

    Deliberative or Performative? Constitutional Reform and the Politics of Public Engagement in New Zealand

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    A key assumption that shapes debates over deliberative constitutionalism is the idea that ‘deliberation’ versus the wielding political power based upon partisan influence somehow represent different poles of the constitutional-deliberative coin. This dualism is problematic. While the term ‘deliberation’ means careful consideration and purposeful and dispassionate decision-making, its adjectival form ‘deliberate’ may also imply ‘calculated’, ‘premeditated’ and ‘controlled’. How democracies deliberate is arguably an empirical and political question rather than a theoretical or normative one. This paper sets out to explore these themes in the context of New Zealand, a country that has had three major constitutional deliberations since 2005. Framed by government as ‘national conversations’ on ‘the future of New Zealand’, these include two initiatives aimed at engaging the public’s views on constitutional reform and a recent consultation over proposals to change the national flag. What is striking about these popular constitutional initiatives, however, is the lack of public engagement or serious government interest. We argue that these ‘non-event’ deliberations highlight one of the key challenges for deliberative constitutionalism: how to prevent instrumentalism and performativity from overshadowing the substantive. In developing our argument we draw on anthropological fieldwork on the role of the Crown in New Zealand and the Commonwealth. As we aim to show, the New Zealand case study highlights yet another problem for deliberative constitutionalism in practice: the difficulties of creating a meaningful public consultation when the main terms of reference (‘Crown’ and ‘Constitution’) are so ambiguous, amorphous and poorly understood

    What Do We Like About the IS Field?

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    What do we like about the IS field? This article is based on a panel discussion at the 2009 International Conference on Information Systems (ICIS) held in Phoenix, Arizona. The panel was sponsored by the Senior Scholars’ Consortium. Given the recent enrolment downturn in IS programs and concerns expressed by some about the strength of the field, this article sets out the views of some senior scholars who describe what they like about the IS field

    The acceptability of nicotine containing products as alternatives to cigarettes: findings from two pilot studies

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    <p>Abstract</p> <p>Background</p> <p>This study aimed to explore issues that might impact on the acceptability and feasibility of offering smokers nicotine containing products either to quit nicotine use altogether by using as a short term means of quitting cigarettes or as a longer term substitute.</p> <p>Method</p> <p>Two small pilot studies, one in the UK (n = 34) involving face to face contact and direct provision of the product, the other in Australia (n = 31) conducted remotely with products sent in the mail.</p> <p>Results</p> <p>Nicotine lozenges were the most popular products, but significant minorities liked a smokeless product more. Use stimulated interest in quitting, and although many failed to use all the products provided, most were interested in future use, more often to help quit than as a planned long-term substitute.</p> <p>Conclusions</p> <p>These studies indicate an untapped interest in the use of substitutes to reduce the harmfulness of smoking. Studies of this sort do not inhibit interest in quitting nicotine altogether, and may facilitate it. The greater the range of products on offer, the more smokers are likely to try a product to quit.</p
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