509 research outputs found

    Finding Their Why : Examining the Development of Sense of Purpose During the University Years and Its Role in Student Well-Being

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    Nearly 20 million students were expected to be enrolled for college or university studies during the 2020-2021 academic year. These institutions often advertise to prospective students that, in addition to advancing their education, they will discover their purpose. Given previous work and current interest in sense of purpose, additional attention on sense of purpose in the university setting is worthwhile. In addition, as many university stakeholders are concerned about an ongoing mental health crisis, a further examination into a developmental construct (i.e. sense of purpose) thought to provide a “sheltering fortress in a world of constant threat” seems especially relevant. In the present two-study dissertation, Study 1, a quantitative study, was designed to examine sense of purpose as a potential buffer between university-related stress and psychological distress. Results from this study suggest sense of purpose moderates the relationship between stress and burnout for sophomores but not other years in school. Study 2, a qualitative study, was designed to provide an in-depth exploration into the perceptions of graduating seniors on the development of their sense of purpose during the university experience. Results from this study highlight that participants’ perceptions that the university played a key role in exposing them to a broader world, helping further establish identity and values, while providing structure and support. Independently, the studies possess the potential to offer unique contributions to current understanding of sense of purpose and inform meaningful research directions in the future. Considered together, the results have the potential to offer important practical considerations for college and university staff and administrators involved with student well-being and retention

    Stillbirth: A Phenomenological Exploration of the Clinical Encounter for Couples

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    With approximately 65 stillbirths occurring each day in the United States, a significant number of parents are left to navigate a difficult grieving process. An event like stillbirth presents many individual and relational challenges. For this study, researchers focused on the hospital experience for couples following notification of stillbirth. Interviews were held with 8 couples that had experienced stillbirth within the past 10 years. Researchers wanted to know what similarities and differences existed in how mothers and fathers described the clinical encounter. The data for this study were collected through interviews. Couples were encouraged to share as much or as little as they’d like about the hospital experience. Couples were also asked to describe how they experienced the clinical encounter as individuals and as a couple. Participants in this study were also given the opportunity to provide feedback on what doctors and other hospital staff could do to assist individuals and couples during this difficult time. Participants discussed how hospital staff helped to shape the experience. This was done both in their interactions with staff and the accommodations that were made. Some parents described hospital staff as “gems” or their “angels” while others reported the pain of hospital staff invalidating their experience. While similarities existed in how parents experienced the clinical encounter, each participant’s experience was unique. Studies should continue to be conducted in an effort to further develop evidence-based practices in hospitals meant to help parents navigate this difficult experience

    Student Attitudes Toward Research in an Undergraduate Social Science Research Methods Course

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    This study used a mixed-methods longitudinal design to investigate change in students’ understanding, attitudes, anxiety, perceptions of relevance, and disinterest in a required social science undergraduate research methods course across a semester. Participants were 78 undergraduates (94% women, 6% men; 92% white non-Hispanic/Latinx, M age = 25.62, SD = 7.17) at a university in the United States. Results suggest that participant attitudes toward and perceptions of research methods shifted over the course of the semester. Overall, anxiety decreased, while positive attitudes increased. However, initial perceptions and changes in perceptions varied among the three course sections. Over time, students largely recognized the course’s relevance and conveyed positive attitudes toward research and their success in overcoming the challenge of completing the course. Implications for pedagogy include the need for continued assessment of learners, development of students’ self-concept as researchers, teaching of research as a process, and connection to application

    A survey of statistics in three UK general practice journal

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    Background Many medical specialities have reviewed the statistical content of their journals. To our knowledge this has not been done in general practice. Given the main role of a general practitioner as a diagnostician we thought it would be of interest to see whether the statistical methods reported reflect the diagnostic process. Methods Hand search of three UK journals of general practice namely the British Medical Journal (general practice section), British Journal of General Practice and Family Practice over a one-year period (1 January to 31 December 2000). Results A wide variety of statistical techniques were used. The most common methods included t-tests and Chi-squared tests. There were few articles reporting likelihood ratios and other useful diagnostic methods. There was evidence that the journals with the more thorough statistical review process reported a more complex and wider variety of statistical techniques. Conclusions The BMJ had a wider range and greater diversity of statistical methods than the other two journals. However, in all three journals there was a dearth of papers reflecting the diagnostic process. Across all three journals there were relatively few papers describing randomised controlled trials thus recognising the difficulty of implementing this design in general practice

    Entanglement generation by adiabatic navigation in the space of symmetric multi-particle states

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    We propose a technique for robust and efficient navigation in the Hilbert space of entangled symmetric states of a multiparticle system with externally controllable linear and nonlinear collective interactions. A linearly changing external field applied along the quantization axis creates a network of well separated level crossings in the energy diagram of the collective states. One or more transverse pulsed fields applied at the times of specific level crossings induce adiabatic passage between these states. By choosing the timing of the pulsed field appropriately, one can transfer an initial product state of all N spins into (i) any symmetric state with n spin excitations and (ii) the N-particle analog of the Greenberger-Horne-Zeilinger state. This technique, unlike techniques using pulses of specific area, does not require precise knowledge of the number of particles and is robust against variations in the interaction parameters. We discuss potential applications in two-component Bose condensates and ion-trap systems.Comment: 7 pages, 6 figure

    The politicisation of science in the Murray-Darling Basin, Australia:discussion of ‘Scientific integrity, public policy and water governance’

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    Many water scientists aim for their work to inform water policy and management, and in pursuit of this objective, they often work alongside government water agencies to ensure their research is relevant, timely and communicated effectively. A paper in this issue, examining 'Science integrity, public policy and water governance in the Murray-Darling Basin, Australia’, suggests that a large group of scientists, who work on water management in the Murray-Darling Basin (MDB) including the Basin Plan, have been subject to possible ‘administrative capture'. Specifically, it is suggested that they have advocated for policies favoured by government agencies with the objective of gaining personal benefit, such as increased research funding. We examine evidence for this claim and conclude that it is not justified. The efforts of scientists working alongside government water agencies appear to have been misinterpreted as possible administrative capture. Although unsubstantiated, this claim does indicate that the science used in basin water planning is increasingly caught up in the politics of water management. We suggest actions to improve science-policy engagement in basin planning, to promote constructive debate over contested views and avoid the over-politicisation of basin science

    Gender and sexual orientation differences in cognition across adulthood : age is kinder to women than to men regardless of sexual orientation

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    Despite some evidence of greater age-related deterioration of the brain in males than in females, gender differences in rates of cognitive aging have proved inconsistent. The present study employed web-based methodology to collect data from people aged 20-65 years (109,612 men; 88,509 women). As expected, men outperformed women on tests of mental rotation and line angle judgment, whereas women outperformed men on tests of category fluency and object location memory. Performance on all tests declined with age but significantly more so for men than for women. Heterosexuals of each gender generally outperformed bisexuals and homosexuals on tests where that gender was superior; however, there were no clear interactions between age and sexual orientation for either gender. At least for these particular tests from young adulthood to retirement, age is kinder to women than to men, but treats heterosexuals, bisexuals, and homosexuals just the same

    Vaccine effectiveness against COVID-19 among symptomatic persons aged ≄12 years with reported contact with COVID-19 cases, February-September 2021

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    BACKGROUND: Individuals in contact with persons with COVID-19 are at high risk of developing COVID-19; protection offered by COVID-19 vaccines in the context of known exposure is poorly understood. METHODS: Symptomatic outpatients aged ≄12 years reporting acute onset of COVID-19-like illness and tested for SARS-CoV-2 between February 1 and September 30, 2021 were enrolled. Participants were stratified by self-report of having known contact with a COVID-19 case in the 14 days prior to illness onset. Vaccine effectiveness was evaluated using the test-negative study design and multivariable logistic regression. RESULTS: Among 2229 participants, 283/451 (63%) of those reporting contact and 331/1778 (19%) without known contact tested SARS-CoV-2-positive. Adjusted vaccine effectiveness was 71% (95% confidence interval [CI], 49%-83%) among fully vaccinated participants reporting a known contact versus 80% (95% CI, 72%-86%) among those with no known contact (p-value for interaction = 0.2). CONCLUSIONS: This study contributes to growing evidence of the benefits of vaccinations in preventing COVID-19 and support vaccination recommendations and the importance of efforts to increase vaccination coverage

    Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-ÎČ-lactamase NDM-1

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    In an effort to characterize the roles of each metal ion in metallo-ÎČ-lactamase NDM-1, heterodimetallic analogues (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV–vis, 1H NMR, EPR, and EXAFS spectroscopies were used to confirm the fidelity of the metal substitutions, including the presence of a homogeneous, heterodimetallic cluster, with a single-atom bridge. This marks the first preparation of a metallo-ÎČ-lactamase selectively substituted with a paramagnetic metal ion, Co(II), either in the Zn1 (CoCd-NDM-1) or in the Zn2 site (ZnCo-NDM-1), as well as both (CoCo-NDM-1). We then used these metal-substituted forms of the enzyme to probe the reaction mechanism, using steady-state and stopped-flow kinetics, stopped-flow fluorescence, and rapid-freeze-quench EPR. Both metal sites show significant effects on the kinetic constants, and both paramagnetic variants (CoCd- and ZnCo-NDM-1) showed significant structural changes on reaction with substrate. These changes are discussed in terms of a minimal kinetic mechanism that incorporates all of the data
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